Capitalizing on recent rapid advances in mass spectrometry instrumentation to deliver the much needed improved sensitivity, selectivity and throughput in protein modification analysis, proteomics, glycomics and glycoproteomics, without compromising precision. The current focus areas and enabling MS-based techniques to be developed include:

• high throughput and high sensitivity LC-MS/MS-based mapping and sequencing of complex N- and O-glycans, towards a global and targeted glycomics of sufficient breadth and depth;
• functional sulfoglycomics, towards unraveling myriad sulfated glycotopes implicated in mediating cell-cell interactions, particularly those of human and mouse myeloid and lymphoid cells and tissues;
• glycopeptide sequencing/identification MS data acquisition and analysis workflows, towards efficient localization of biologically implicated and/or structurally interesting glycotopes onto their protein carriers;
• quantitative determination of site-specific Cys modifications and the dynamics of their inter-conversion, particularly those of receptor protein tyrosine phosphatase

Positions Held

• 2012 – present   Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 2017 – 2019   Acting Director, Institute of Biological Chemistry, Academia Sinica
• 2012 – 2017   Associate Director, Institute of Biological Chemistry, Academia Sinica
• 2008 – 2012   Research Fellow, Institute of Biological Chemistry, Academia Sinica
• 1996 – 2008   Associate Research Fellow , Institute of Biological Chemistry, Academia Sinica
• 1994 – 1996   Postdoctoral Fellow, Colorado State University,
• 1992 – 1994   Postdoctoral Fellow , Imperial College, University of London.

Degrees

• 1989 – 1992   Ph.D. , Biochemistry, Imperial College, University of London.
• 1986 – 1989   B.S. , Biochemistry, Imperial College, University of London.

1. Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, (Khoo KH), Chang HW, Hsu STD  (2020-01)  Proceedings of the National Academy of Sciences of the United States of America  117(3),1438-1446  "Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans."
   
2. Wong KKL, Liu TW, Parker JM, Sinclair DAR, Chen YY, (Khoo KH), Vocadlo DJ, Verheyen EM  (2020-01)  Proceedings of the National Academy of Sciences of the United States of America  117(4), 2004-2013  "The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila."
   
3. Lin CY, Lai HL, Chen HM, Siew JJ, Hsiao CT, Chang HC, Liao KS, Tsai SC, Wu CY, Kitajima K, Sato C, (Khoo KH), Chern Y  (2019-08)  Translational psychiatry  9(1), 209  "Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors."
   
4. Khoo KH  (2019-06)  Current opinion in structural biology  56, 146-154  "Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity."
   
5. Chang LY, Teppa E, Noel M, Gilormini PA, Decloquement M, Lion C, Biot C, Mir AM, Cogez V, Delannoy P, (Khoo KH), Petit D, Guerardel Y, Harduin-Lepers A  (2019-02)  International journal of molecular sciences  20(3), 622  "Novel Zebrafish Mono-alpha2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of alpha2,8-Sialylation."
   
6. Yamakawa N, Vanbeselaere J, Chang LY, Yu SY, Ducrocq L, Harduin-Lepers A, Kurata J, Aoki-Kinoshita KF, Sato C, (Khoo KH), Kitajima K, Guerardel Y  (2018-11)  Nature communications  9(1), 4647  "Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns."
   
7. Yu SY, Hsiao CT, Izawa M, Yusa A, Ishida H, Nakamura S, Yagi H, Kannagi R, (Khoo KH)  (2018-09)  The Journal of biological chemistry  293(39), 15163-15177  "Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis."
   
8. Huang YL, Jhou BY, Chen SF, (Khoo KH)  (2018-09)  Analytical sciences  34(9), 1049-1054  "Identifying Specific and Differentially Linked Glycosyl Residues in Mammalian Glycans by Targeted LC-MS Analysis."
   
9. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, (Khoo KH), Hung MC  (2018-08)  Molecular cell  71(4), 606-620.e7  "Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1."
   
10. Kuo CW, Guu SY, (Khoo KH)  (2018-06)  Journal of the American Society for Mass Spectrometry  29(6), 1166-1178  "Distinctive and Complementary MS(2) Fragmentation Characteristics for Identification of Sulfated Sialylated N-Glycopeptides by nanoLC-MS/MS Workflow."
    
11. Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, (Khoo KH), Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC  (2018-05)  Nature communications  9(1), 1908  "STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion."
    
12. Yu CH, Chou CC, Tu HF, Huang WC, Ho YY, (Khoo KH), Lee MS, Chang GD  (2018-04)  Oncotarget  9(30), 21512-21529  "Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase."
    
13. Yu CH, Chou CC, Lee DY, (Khoo KH), Chang GD  (2018-04)  Bioscience reports  38(2), BSR20171717  "Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives."
    
14. Moginger U, Grunewald S, Hennig R, Kuo CW, Schirmeister F, Voth H, Rapp E, (Khoo KH), Seeberger PH, Simon JC, Kolarich D  (2018-03)  Frontiers in oncology  8, 70  "Alterations of the Human Skin N- and O-Glycome in Basal Cell Carcinoma and Squamous Cell Carcinoma."
    
15. Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, (Khoo KH), Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC  (2018-02)  Cancer cell  33(2), 187-201.e10  "Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1."
    
16. Chen JY, Huang HH, Yu SY, Wu SJ, Kannagi R and (Khoo KH)*  (2018-01)  Glycobiology  28(1), 9-20  "Concerted mass spectrometry-based glycomic approach for precision mapping of sulfo sialylated N-glycans on human peripheral blood mononuclear cells and lymphocytes."
    
17. Hsiao CT, Wang PW, Chang HC, Chen YY, Wang SH, Chern Y and (Khoo KH)*  (2017-12)  Molecular Cellular Proteomics  16(12), 2268-2280  "Advancing a high throughput glycotope-centric glycomics workflow based on nanoLC-MS2-product dependent-MS3 analysis of permethylated glycans."
    
18. Hsiao CT, Cheng HW, Huang CM, Li HR, Ou MH, Huang JR, (Khoo KH), Yu HW, Chen YQ, Wang YK, Chiou A, Kuo JC  (2017-09)  Oncotarget  8(41), 70653-70668  "Fibronectin in cell adhesion and migration via N-glycosylation."
    
19. Pan KT, Chen CC, Urlaub H, (Khoo KH)*  (2017-04)  Analytical chemistry  89(8), 4532-4539  "Adapting data-independent acquisition for mass spectrometry-based protein site-specific N-glycosylation analysis."
    
20. Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, (Khoo KH), Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DF  (2017-04)  Glycobiology  27(4), 280-284  "The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data."
    
21. Yagi H, Kuo CW, Obayashi T, Ninagawa S, (Khoo KH)*, Kato K*  (2016-11)  MOLECULAR & CELLULAR PROTEOMICS  15(11), 3424-3434  "Direct mapping of additional modifications on phosphorylated O-glycans of alpha-dystroglycan by mass spectrometry analysis in conjunction with knocking out of causative genes for dystroglycanopathy."
    
22. Hsu MF, Pan KT, Chang FY, (Khoo KH), Urlaub H, Cheng CF, Chang GD, Haj FG and Meng TC  (2016-10)  Free Radical Biology and Medicine  99, 199-213  "S-Nitrosylation of Endogenous Protein Tyrosine Phosphatases in Endothelial Insulin Signaling"
    
23. Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Ten Feizi, Haslam SM, Karlsson NG, (Khoo KH), Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C  (2016-09)  Glycobiology  26(9), 907-910  "The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets."
    
24. Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, (Khoo KH), Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC  (2016-08)  Nature communications  7, 12632  "Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity."
    
25. Wu JL, Wu HY, Tsai DY, Chiang MF, Chen YJ, Gao S, Lin CC, Lin CH, (Khoo KH), Chen YJ, Lin KI  (2016-08)  Nature communications  7, 12526  "Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells."
    
26. Yeh SC, Wang PY, Lou YW, (Khoo KH), Hsiao M, Hsu TL, Wong CH  (2016-05)  Proceedings of the National Academy of Sciences of the United States of America  113(20), 5592-5597  "Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity."
    
27. Mabashi-Asazuma H, Sohn BH, Kim YS, Kuo CW, (Khoo KH), Kucharski CA, Fraser MJ Jr, Jarvis DL  (2015-7)  Insect biochemistry and molecular biology  65, 20-27  "Targeted glycoengineering extends the protein N-glycosylation pathway in the silkworm silk gland."
    
28. Hsieh YC, Chen YM, Li CY, Chang YH, Liang SY, Lin SY, Lin CY, Chang SH, Wang YJ, (Khoo KH), Aoki T, Wang HC  (2015-6)  Developmental and comparative immunology  53(1), 85-95  "To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1alpha pathway."
    
29. Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kannagi R, (Khoo KH), Paulson JC*  (2015-12)  The Journal of Biological Chemistry  290(50), 30066-30077  "Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man."
    
30. Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL  (2015-10)  ACS chemical biology  10(10), 2199-2208  "Modifying an Insect Cell N-Glycan Processing Pathway Using CRISPR-Cas Technology."
    
31. Lin HC, Ho SC, Chen YY, (Khoo KH), Hsu PH, Yen HC  (2015-07)  Science  349(6243), 91-95  "CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding."
    
32. Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, (Khoo KH), Chang GD, Wu CW, Meng TC, Chen GC  (2015-07)  Oncogene  34(29), 3791-3803  "Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation."
    
33. Cheng CW, Chou CC, Hsieh HW, Tu Z, Lin CH, Nycholat CM, Fukuda M, (Khoo KH)*  (2015-06)  Analytical chemistry  87(12), 6380-6388  "Efficient mapping of sulfated glycotopes by negative ion mode nanoLC-MS/MS-based sulfoglycomic analysis of permethylated glycans."
    
34. Yu CH, Chou CC, Lee YJ, (Khoo KH), Chang GD  (2015-03)  Amino acids  47(3), 469-481  "Uncovering protein polyamination by the spermine-specific antiserum and mass spectrometric analysis."
    
35. Chou CC, Chiang BY, Lin JC, Pan KT, Lin CH, (Khoo KH)*  (2015-01)  Journal of the American Society for Mass Spectrometry  26(1), 120-132  "Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein s-glutathionylation."
    
36. Geisler C, Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL  (2015-01)  Journal of biotechnology  193, 52-65  "Engineering beta1,4-galactosyltransferase I to reduce secretion and enhance N-glycan elongation in insect cells."
    
37. Lo HJ, Chu WL, Liou CH, Huang SH, (Khoo KH), Yang YL  (2015-01)  International journal of medical microbiology : IJMM  305(1), 170-173  "Ndt80p is involved in l-sorbose utilization through regulating SOU1 in Candida albicans."
    
38. Chen YJ, Ching WC, Chen JS, Lee TY, Lu CT, Chou HC, Lin PY, (Khoo KH), Chen JH, Chen YJ  (2014-11)  Journal of proteome research  13(11), 4942-4958  "Decoding the S-nitrosoproteomic Atlas in Individualized Human Colorectal Cancer Tissues Using a Label-free Quantitation Strategy."
    
39. Kaur D, Angala SK, Wu SW, (Khoo KH), Chatterjee D, Brennan PJ, Jackson M, McNeil MR  (2014-10)  The Journal of biological chemistry  289(44), 30249-30256  "A Single Arabinan Chain Is Attached to the Phosphatidylinositol Mannosyl Core of the Major Immunomodulatory Mycobacterial Cell Envelope Glycoconjugate, Lipoarabinomannan."
    
40. Huang IH, Hsiao CT, Wu JC, Shen RF, Liu CY, Wang YK, Chen YC, Huang CM, Del Alamo JC, Chang ZF, Tang MJ, (Khoo KH), Kuo JC  (2014-10)  Journal of cell science  127(19), 4186-4200  "GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment."
    
41. Lin JC, Chou CC, Tu Z, Yeh LF, Wu SC, (Khoo KH), Lin CH  (2014-08)  Journal of proteome research  13(8), 3523-3529  "Characterization of Protein Serotonylation via Bioorthogonal Labeling and Enrichment."
    
42. Toth AM, Kuo CW, (Khoo KH), Jarvis DL  (2014-07)  Journal of biotechnology  182-183, 19-29  "A new insect cell glycoengineering approach provides baculovirus-inducible glycogene expression and increases human-type glycosylation efficiency."
    
43. Liang SY, Wu SW, Pu TH, Chang FY, (Khoo KH)  (2014-07)  Bioinformatics  30(13), 1908-1916  "An Adaptive Workflow Coupled with Random Forest Algorithm to Identify Intact N-glycopeptides Detected from Mass Spectrometry."
    
44. Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, (Khoo KH), Chang GD, Lo CF, Wang HC  (2014-07)  PLoS pathogens  10(6), e1004196  "An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway."
    
45. Wang YM, Tsai IH, Chen JM, Cheng AC, (Khoo KH)  (2014-06)  PloS one  9(6), e100354  "Correlation between the Glycan Variations and Defibrinogenating Activities of Acutobin and Its Recombinant Glycoforms."
    
46. Wu SW, Pu TH, Viner R, (Khoo KH)  (2014-06)  Analytical Chemistry  86(11), 5478-5486  "Novel LC-MS(2) Product Dependent Parallel Data Acquisition Function and Data Analysis Workflow for Sequencing and Identification of Intact Glycopeptides."
    
47. York WS, Agravat S, Aoki-Kinoshita KF, McBride R, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson N, (Khoo KH), Kolarich D, Liu Y, Novotny M, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Struwe WB, Tiemeyer M, Wells L, Zaia J, Kettner C  (2014-05)  Glycobiology  24(5), 402-406  "MIRAGE: The minimum information required for a glycomics experiment."
    
48. Tsai CM, Wu HY, Su TH, Kuo CW, Huang HW, Chung CH, Chen CS, (Khoo KH), Chen YJ, Lin KI  (2014-05)  Journal of proteomics  103C, 241-253  "Phosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling."
    
49. Mabashi-Asazuma H, Kuo CW, (Khoo KH), Jarvis DL  (2014-03)  Glycobiology  24(3), 325-340  "A novel baculovirus vector for the production of nonfucosylated recombinant glycoproteins in insect cells."
    
50. Pan KT, Chen YY, Pu TH, Chao YS, Yang CY, Bomgarden RD, Rogers JC, Meng TC, (Khoo KH)  (2014-03)  Antioxidants & redox signaling  20(9), 1365-1381  "Mass Spectrometry-Based Quantitative Proteomics for Dissecting Multiplexed Redox Cysteine Modifications in Nitric Oxide-Protected Cardiomyocyte Under Hypoxia."
    
51. Lou YW, Wang PY, Yeh SC, Chuang PK, Li ST, Wu CY, (Khoo KH), Hsiao M, Hsu TL, Wong CH  (2014-02)  Proceedings of the National Academy of Sciences of the United States of America  111(7), 2482-2487  "Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers."
    
52. Lin CH, Kuo CW, Jarvis DL, (Khoo KH)  (2014-01)  Proteomics  14(1), 87-92  "Facile removal of high mannose structures prior to extracting complex type N-glycans from de-N-glycosylated peptides retained by C18 solid phase to allow more efficient glycomic mapping."
    
53. (Khoo KH)  (2014)  Advances in neurobiology  9, 129-164  "From mass spectrometry-based glycosylation analysis to glycomics and glycoproteomics."
    
54. Aoki-Kinoshita KF, Sawaki H, An HJ, Campbell M, Cao Q, Cummings R, Hsu DK, Kato M, Kawasaki T, (Khoo KH), Kim J, Kolarich D, Li X, Liu M, Matsubara M, Okuda S, Packer NH, Ranzinger R, Shen H, Shikanai T, Shinmachi D, Toukach P, Yamada I, Yamaguchi Y, Yang P, Ying W, Yoo JS, Zhang Y, Zhang Y, Narimatsu H  (2013-12)  Glycobiology  23(12), 1422-1424  "The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository."
    
55. Yagi H, Nakagawa N, Saito T, Kiyonari H, Abe T, Toda T, Wu SW, (Khoo KH), Oka S, Kato K  (2013-11)  Scientific Reports  3, 3288  "AGO61-dependent GlcNAc modification primes the formation of functional glycans on alpha-dystroglycan."
    
56. Sugihara K, Shibata TK, Takata K, Kimura T, Kanayama N, Williams R, Hatakeyama S, Akama TO, Kuo CW, (Khoo KH), Fukuda MN  (2013-10)  FEBS letters  587(19), 3195-3201  "Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans."
    
57. Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, (Khoo KH), Wu SH  (2013-10)  Molecular & cellular proteomics : MCP  12(10), 2701-2713  "Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27."
    
58. Loo CS, Chen CW, Wang PJ, Chen PY, Lin SY, (Khoo KH), Fenton RA, Knepper MA, Yu MJ  (2013-10)  Proceedings of the National Academy of Sciences of the United States of America  110(42), 17119-17124  "Quantitative apical membrane proteomics reveals vasopressin-induced actin dynamics in collecting duct cells."
    
59. Lu YW, Chien CW, Lin PC, Huang LD, Chen CY, Wu SW, Han CL, (Khoo KH), Lin CC, Chen YJ  (2013-09)  Analytical chemistry  85(17), 8268-8276  "BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichment of Glycoproteins."
    
60. Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, (Khoo KH), Rosen SD  (2013-09)  The Journal of biological chemistry  288(37), 26533-26545  "Galactose-6-O-Sulfotransferases Are Not Required for the Generation of Siglec-F Ligands in Leukocytes or Lung Tissue."
    
61. Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, (Khoo KH), Lin CH, Hsu HY, Wu CY, Wong CH  (2013-08)  Proceedings of the National Academy of Sciences of the United States of America  110(34), 13809-13814  "Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes."
    
62. Cheng PF, Snovida S, Ho MY, Cheng CW, Wu AM, (Khoo KH)  (2013-08)  Analytical and bioanalytical chemistry  405(21), 6683-6695  "Increasing the depth of mass spectrometry-based glycomic coverage by additional dimensions of sulfoglycomics and target analysis of permethylated glycans."
    
63. Wang SH, Tsai CM, Lin KI, (Khoo KH)  (2013-06)  Glycobiology  23(6), 677-689  "Advanced mass spectrometry and chemical analyses reveal the presence of terminal disialyl motif on mouse B-cell glycoproteins."
    
64. Wu SW, Liang SY, Pu TH, Chang FY, (Khoo KH)  (2013-06)  Journal of proteomics  84, 1-16  "Sweet-Heart - an integrated suite of enabling computational tools for automated MS2/MS3 sequencing and identification of glycopeptides."
    
65. Lin JC, Chou CC, Gao S, Wu SC, (Khoo KH), Lin CH  (2013-05)  Chembiochem : a European journal of chemical biology  14(7), 813-817  "An in vivo tagging method reveals that Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation."
    
66. Chang YC, Tang HW, Liang SY, Pu TH, Meng TC, (Khoo KH), Chen GC  (2013-05)  Journal of proteome research  12(5), 2138-2150  "Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation."
    
67. Suzuki N, Nawa D, Su TH, Lin CW, (Khoo KH), Yamamoto K  (2013-03)  PloS one  8(3), e59291  "Distribution of the Galbeta1-4Gal Epitope among Birds: Species-Specific Loss of the Glycan Structure in Chicken and Its Relatives."
    
68. Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjo L, Sakuma K, Uchimura K, (Khoo KH), Kannagi R, Rosen SD  (2013-03)  Glycobiology  23(3), 381-394  "KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing."
    
69. Mabashi-Asazuma H, Shi X, Geisler C, Kuo CW, (Khoo KH), Jarvis DL  (2013-02)  Glycobiology  23(2), 199-210  "Impact of a human CMP-sialic acid transporter on recombinant glycoprotein sialylation in glycoengineered insect cells."
    
70. Suzuki-Anekoji M, Suzuki A, Wu SW, Angata K, Murai KK, Sugihara K, Akama TO, (Khoo KH), Nakayama J, Fukuda MN, Fukuda M  (2013-02)  The Journal of biological chemistry  288(7), 5007-5016  "In vivo regulation of steroid hormones by the chst10 sulfotransferase in mouse."
    
71. Aoki-Kinoshita KF, Sawaki H, An HJ, Cho JW, Hsu D, Kato M, Kawano S, Kawasaki T, (Khoo KH), Kim J, Kim JD, Li X, Lutteke T, Okuda S, Packer NH, Paulson JC, Raman R, Ranzinger R, Shen H, Shikanai T, Yamada I, Yang P, Yamaguchi Y, Ying W, Yoo JS, Zhang Y, Narimatsu H  (2013-02)  Glycobiology  23(2), 144-146  "The Third ACGG-DB Meeting Report: Towards an international collaborative infrastructure for glycobioinformatics."
    
72. Yu SY, Chang LY, Cheng CW, Chou CC, Fukuda MN, (Khoo KH)  (2013-01)  Glycoconjugate journal  30(2), 183-194  "Priming mass spectrometry-based sulfoglycomic mapping for identification of terminal sulfated lacdiNAc glycotope."
    
73. Gupta V, Bhinge KN, Hosain SB, Xiong K, Gu X, Shi R, Ho MY, (Khoo KH), Li SC, Li YT, Ambudkar SV, Jazwinski SM, Liu YY  (2012-10)  The Journal of biological chemistry  287(44), 37195-37205  "Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells."
    
74. Tsai IH, Chang HC, Chen JM, Cheng AC, (Khoo KH)  (2012-08)  The FEBS journal  279(15), 2672-2682  "Glycan structures and intrageneric variations of venom acidic phospholipases A(2) from Tropidolaemus pitvipers."
    
75. Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, (Khoo KH), Lin CH  (2012-06)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  51(24), 5871-5875  "In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method."
    
76. Shibata TK, Matsumura F, Wang P, Yu S, Chou CC, (Khoo KH), Kitayama K, Akama TO, Sugihara K, Kanayama N, Kojima-Aikawa K, Seeberger PH, Fukuda M, Suzuki A, Aoki D, Fukuda MN  (2012)  The Journal of biological chemistry  287(9), 6592-6602  "Identification of mono- and disulfated N-acetyl-lactosaminyl Oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer."
    
77. Coddeville B, Wu SW, Fabre E, Brassart C, Rombouts Y, Burguiere A, Kremer L, (Khoo KH), Elass-Rochard E, Guerardel Y  (2012)  Journal of proteomics  75(18), 5695-5705  "Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue."
    
78. Vanbeselaere J, Chang LY, Harduin-Lepers A, Fabre E, Yamakawa N, Slomianny C, Biot C, (Khoo KH), Guerardel Y  (2012)  Journal of proteome research  11(4), 2164-2177  "Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies."
    
79. Kuo-Yuan Hwa, Boopathi Subramani and (Kay-Hooi Khoo)  (2012)  SOFT COMPUTING  16(3), 381-391  "Putative xylosyltransferase genes in Trichomonas vaginalis"
    
80. Kuo CW, Wu IL, Hsiao HH, (Khoo KH)  (2012)  Analytical and bioanalytical chemistry  402(9), 2765-2776  "Rapid glycopeptide enrichment and N-glycosylation site mapping strategies based on amine-functionalized magnetic nanoparticles."
    
81. Liang YJ, Yang BC, Chen JM, Lin YH, Huang CL, Cheng YY, Hsu CY, (Khoo KH), Shen CN, Yu J  (2011-12)  Stem Cells  29(12), 1995-2004  "Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages."
    
82. Lai YC, Pan KT, Chang GF, Hsu CH, (Khoo KH), Hung CH, Jiang YJ, Ho FM, Meng TC  (2011-12)  Circulation research  109(12), 1375-1386  "Nitrite-Mediated S-Nitrosylation of Caspase-3 Prevents Hypoxia-Induced Endothelial Barrier Dysfunction."
    
83. Wang CL, Pi CC, Kuo CW, Zhuang YJ, (Khoo KH), Liu WH, Chen CJ  (2011-11)  Biotechnology letters  33(11), 2271-2278  "Polysaccharides purified from the submerged culture of Ganoderma formosanum stimulate macrophage activation and protect mice against Listeria monocytogenes infection."
    
84. Poh-Choo Pang*, Philip C. N. Chiu*, Cheuk-Lun Lee, Lan-Yi Chang, Maria Panico, Howard R. Morris, Stuart M. Haslam, (Kay-Hooi Khoo), Gary F. Clark, William S. B. Yeung, Anne Dell  (2011-09)  Science  333(6050), 1761-1764  "Human Sperm Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida"
    
85. Li YT, Li SC, Buck WR, Haskins ME, Wu SW, (Khoo KH), Sidransky E, Bunnell BA  (2011-09)  Neurochemical research  36(9), 1612-1622  "Selective Extraction and Effective Separation of Galactosylsphingosine (Psychosine) and Glucosylsphingosine from Other Glycosphingolipids in Pathological Tissue Samples."
    
86. Wang SH, Wu SW, (Khoo KH)  (2011-07)  Proteomics  11(14), 2812-2829  "MS-based glycomic strategies for probing the structural details of polylactosaminoglycan chain on N-glycans and glycoproteomic identification of its protein carriers."
    
87. Liu YC, Yen HY, Chen CY, Chen CH, Cheng PF, Juan YH, Chen CH, (Khoo KH), Yu CJ, Yang PC, Hsu TL, Wong CH  (2011-07)  Proceedings of the National Academy of Sciences of the United States of America  108(28), 11332-11337  "Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells."
    
88. Yeh YY, Shah KH, Chou CC, Hsiao HH, Wrasman KM, Stephan JS, Stamatakos D, (Khoo KH), Herman PK  (2011-07)  Autophagy  7(7), 716-726  "The identification and analysis of phosphorylation sites on the Atg1 protein kinase."
    
89. Tsai HY, Boonyapranai K, Sriyam S, Yu CJ, Wu SW, (Khoo KH), Phutrakul S, Chen ST  (2011-06)  Proteomics  11(11), 2162-2170  "Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer."
    
90. Kobayashi M, Mitoma J, Hoshino H, Yu SY, Shimojo Y, Suzawa K, (Khoo KH), Fukuda M, Nakayama J  (2011-05)  JOURNAL OF PATHOLOGY  224(1), 67-77  "Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma."
    
91. Lin CW, Chen JM, Wang YM, Wu SW, Tsai IH, (Khoo KH)  (2011-04)  Glycobiology  21(4), 530-542  "Terminal disialylated multiantennary complex-type N-glycans carried on acutobin define the glycosylation characteristics of the Deinagkistrodon acutus venom."
    
92. Huang KY, Chen GD, Cheng CH, Liao KY, Hung CC, Chang GD, Hwang PP, Lin SY, Tsai MC, (Khoo KH), Lee MT, Huang CJ  (2011)  PloS one  6(10), e26461  "Phosphorylation of the Zebrafish M6Ab at Serine 263 Contributes to Filopodium Formation in PC12 Cells and Neurite Outgrowth in Zebrafish Embryos."
    
93. Chen YJ, Ku WC, Lin PY, Chou HC, (Khoo KH), Chen YJ  (2010-12)  Journal of proteome research  9(12), 6417-6439  "S-alkylating labeling strategy for site-specific identification of the s-nitrosoproteome."
    
94. Liang YJ, Kuo HH, Lin CH, Chen YY, Yang BC, Cheng YY, Yu AL, (Khoo KH), Yu J  (2010-12)  Proceedings of the National Academy of Sciences of the United States of America  107(52), 22564-22569  "Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation."
    
95. Lee SH, Yu SY, Nakayama J, (Khoo KH), Stone EL, Fukuda MN, Marth JD, Fukuda M  (2010-11)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(48), 37683-37692  "Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation."
    
96. Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Backstrom M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, (Khoo KH), Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N  (2010-04)  MOLECULAR & CELLULAR PROTEOMICS  9(4), 719-727  "Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1."
    
97. Yagi H, Yamamoto M, Yu SY, Takahashi N, (Khoo KH), Lee YC, Kato K  (2010-02)  Carbohydrate research  345(3), 442-448  "N-Glycosylation profiling of turtle egg yolk: expression of galabiose structure."
    
98. (Khoo KH), Yu SY  (2010)  Methods in enzymology  478, 3-26  "Mass spectrometric analysis of sulfated N- and O-glycans."
    
99. Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH.  (2009-12)  MOLECULAR & CELLULAR PROTEOMICS  8(12), 2613-2623  "Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence."
    
100. Lee SH, Hatakeyama S, Yu SY, Bao X, Ohyama C, Khoo KH, Fukuda MN, Fukuda M  (2009)  The Journal of biological chemistry  284(25), 17157-17169  "Core3 O-Glycan Synthase Suppresses Tumor Formation and Metastasis of Prostate Carcinoma PC3 and LNCaP Cells through Down-regulation of {alpha}2{beta}1 Integrin Complex."
     
101. Hsiao ES, Chen JC, Tsai HY, Khoo KH, Chen ST, Tzen JT  (2009)  Journal of agricultural and food chemistry  57(15), 6757-6763  "Determination of N-Glycosylation Site and Glycan Structures of Pectin Methylesterase in Jelly Fig (Ficus awkeotsang) Achenes."
     
102. Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guerardel Y  (2009)  Glycoconjugate journal  26(3), 247-261  "Developmental regulation of oligosialylation in zebrafish."
     
103. Yu SY, Wu SW, Hsiao HH, Khoo KH  (2009)  Glycobiology  19(10), 1136-1149  "Enabling techniques and strategic workflow for sulfoglycomics based on mass spectrometry mapping and sequencing of permethylated sulfated glycans."
     
104. Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, Yu LC, Khoo KH  (2009)  Glycobiology  19(4), 418-427  "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
     
105. Wang CC, Chen JR, Tseng YC, Hsu CH, Hung YF, Chen SW, Chen CM, Khoo KH, Cheng TJ, Cheng YS, Jan JT, Wu CY, Ma C, Wong CH  (2009)  Proceedings of the National Academy of Sciences of the United States of America  106(43), 18137-18142  "Glycans on influenza hemagglutinin affect receptor binding and immune response."
     
106. C. W. Kuo, C. M. Chen, Y. C. Lee, S. T. Chu and K. H. Khoo  (2009)  Mol Cell Proteomics  8(2), 325-42  "Glycomic and proteomic analyses of mouse uterine luminal fluid revealed a predominance of Lewis Y and X epitopes on specific protein carriers"
     
107. Kawasaki N, Lin CW, Inoue R, Khoo KH, Kawasaki N, Ma BY, Oka S, Ishiguro M, Sawada T, Ishida H, Hashimoto T, Kawasaki T  (2009)  Glycobiology  19(4), 437-450  "Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26 (DPPVI) isolated from a human colorectal carcinoma cell line, SW1116."
     
108. Yu SY, Yang Z, Khoo KH, Wu AM  (2009)  Proteomics  9(13), 3445-3462  "Identification of blood group A/A-Leb/y and B/B-Leb/y active glycotopes co-expressed on the O-glycans isolated from two distinct human ovarian cyst fluids."
     
109. Suzuki N, Su TH, Wu SW, Yamamoto K, Khoo KH, Lee YC  (2009)  Glycobiology  19(7), 693-706  "Structural analysis of N-glycans from gull egg white glycoproteins and egg yolk IgG."
     
110. Garenaux E, Yu SY, Florea D, Strecker G, Khoo KH, Guerardel Y  (2008)  Glycoconjugate journal  25(9), 903-915  "A single step method for purification of sulfated oligosaccharides."
     
111. Chen YY, Chu HM, Pan KT, Teng CH, Wang DL, Wang AH, Khoo KH, Meng TC  (2008)  The Journal of biological chemistry  283(50), 35265-72  "Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation."
     
112. Yu SY, Khoo KH, Yang Z, Herp A, Wu AM  (2008)  Glycoconjugate journal  25(3), 199-212  "Glycomic mapping of O- and N-linked glycans from major rat sublingual mucin."
     
113. Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo  (2008)  J Biol Chem  283(24), 16455-16468  "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
     
114. Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ  (2008)  Journal of proteome research  7(9), 4058-4069  "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics."
     
115. Chen HS, Chen JM, Lin CW, Khoo KH, Tsai IH  (2008)  The FEBS journal  275(15), 3944-58  "New insights into the functions and N-glycan structures of factor X activator from Russell's viper venom."
     
116. Lin SY, Chen YY, Fan YY, Lin CW, Chen ST, Wang AH, Khoo KH  (2008)  Journal of proteome research  7(8), 3293-303  "Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics."
     
117. C. H. Lin, C. W. Lin and K. H. Khoo  (2008)  Proteomics  8(3), 475-483  "Proteomic identification of specific glycosyltransferases functionally implicated for the biosynthesis of a targeted glyco-epitope"
     
118. Y. W. Lou, Y. Y. Chen, S. F. Hsu, R. K. Chen, C. L. Lee, K. H. Khoo, N. K. Tonks and T. C. Meng  (2008)  FEBS J  275(1), 69-88  "Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells"
     
119. Chen VC, Chou CC, Hsieh HY, Perreault H, Khoo KH  (2008)  JOURNAL OF MASS SPECTROMETRY  43(12), 1649-1658  "Targeted identification of phosphorylated peptides by off-line HPLC-MALDI-MS/MS using LC retention time prediction."
     
120. Yagi H, Yasukawa N, Yu SY, Guo CT, Takahashi N, Takahashi T, Bukawa W, Suzuki T, Khoo KH, Suzuki Y and Kato K.  (2008)  CARBOHYDRATE RESEARCH  343(8), 1373-1377  "The expression of sialylated high-antennary N-glycans in edible bird's nest."
     
121. Bhamidi S, Scherman MS, Rithner CD, Prenni JE, Chatterjee D, Khoo KH, McNeil MR  (2008)  The Journal of biological chemistry  283(19), 12992-3000  "The identification and location of succinyl residues and the characterization of the interior arabinan region allow for a model of the complete primary structure of Mycobacterium tuberculosis mycolyl arabinogalactan."
     
122. Shi L, Zhou R, Liu Z, Lowary TL, Seeberger PH, Stocker BL, Crick DC, Khoo KH, Chatterjee D  (2008)  Journal of bacteriology  190(15), 5248-55  "Transfer of the first arabinofuranose residue to galactan is essential for Mycobacterium smegmatis viability."
     
123. Ying-Che Chang, Shu-Yu Lin, Suh-Yuen Liang, Kuan-Ting Pan, Chi-Chi Chou, Chien-Hung Chen, Chung-Ling Liao, Kay-Hooi Khoo and Tzu-Ching Meng  (2008)  J Proteome Res  7(3), 1055-1066  "Tyrosine Phosphoproteomics and Identification of Substrates of Protein Tyrosine Phosphatase dPTP61F in Drosophila S2 Cells by Mass Spectrometry-Based Substrate Trapping Strategy"
     
124. M. Sutton-Smith, N. K. Wong, K. H. Khoo, S. W. Wu, S. Y. Yu, M. S. Patankar, R. Easton, F. A. Lattanzio, H. R. Morris, A. Dell and G. F. Clark  (2007)  Glycobiology  17(6), 553-567  "Analysis of protein-linked glycosylation in a sperm-somatic cell adhesion system"
     
125. J. Zhang, K. H. Khoo, S. W. Wu and D. Chatterjee  (2007)  J Am Chem Soc  129(31), 9650-9662  "Characterization of a Distinct Arabinofuranosyltransferase in Mycobacterium smegmatis"
     
126. Y. Wada, P. Azadi, C. E. Costello, A. Dell, R. A. Dwek, H. Geyer, R. Geyer, K. Kakehi, N. G. Karlsson, K. Kato, N. Kawasaki and K. H. Khoo et. al.  (2007)  Glycobiology  17(4), 411-422  "Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study."
     
127. H. H. Hsiao, H. Y. Hsieh, C. C. Chou, S. Y. Lin, A. H. Wang and K. H. Khoo  (2007)  J Proteome Res  6(4), 1313-1324  "Concerted Experimental Approach for Sequential Mapping of Peptides and Phosphopeptides Using C18-Functionalized Magnetic Nanoparticles"
     
128. Mitoma J, Bao X, Petryanik B, Schaerli P, Gauguet JM, Yu SY, Kawashima H, Saito H, Ohtsubo K, Marth JD, Khoo KH, von Andrian UH, Lowe JB, Fukuda M  (2007)  Nature immunology  8(4), 409-418  "Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment."
     
129. Wu AM, Khoo KH, Yu SY, Yang Z, Kannagi R, Watkins WM  (2007)  Proteomics  7(20), 3699-3717  "Glycomic mapping of pseudomucinous human ovarian cyst glycoproteins: identification of Lewis and sialyl Lewis glycotopes."
     
130. Y. Y. Chen, Y. F. Huang, K. H. Khoo and T. C. Meng  (2007)  Methods  42(3), 243-249  "Mass spectrometry-based analyses for identifying and characterizing S-nitrosylation of protein tyrosine phosphatases"
     
131. D. Kaur, M. R. McNeil, K. H. Khoo, D. Chatterjee, D. C. Crick, M. Jackson and P. J. Brennan  (2007)  J Biol Chem  282(37), 27133-27140  "New insights into the biosynthesis of mycobacterial lipomannan arising from deletion of a conserved gene"
     
132. Yu SY, Wu SW, Khoo KH  (2006)  Glycoconjugate journal  23(5-6), 355-369  "Distinctive characteristics of MALDI-Q/TOF and TOF/TOF tandem mass spectrometry for sequencing of permethylated complex type N-glycans."
     
133. Guerardel Y, Chang LY, Maes E, Huang CJ, Khoo KH  (2006)  Glycobiology  16(3), 244-257  "Glycomic survey mapping of zebrafish identifies unique sialylation pattern."
     
134. K. Kitajima, K. H. Khoo and S. I. Hakomori  (2006)  GLYCOCONJUGATE JOURNAL  23(5-6), 273-276  "Introduction. Professor Yasuo Inoue: 1934-2005"
     
135. Wang HL, Yeh KW, Chen PR, Chang CH, Chen JM, Khoo KH  (2006)  Bioscience Biotechnology and Biochemistry  70(2), 551-553  "Isolation and characterization of a pure mannan from Oncidium (cv. Gower Ramsey) current pseudobulb during initial inflorescence development."
     
136. A. Lee, S. W. Wu, M. S. Scherman, J. B. Torrelles, D. Chatterjee, M. R. McNeil and K. H. Khoo  (2006)  Biochemistry  45(51), 15817-15828  "Sequencing of Oligoarabinosyl Units Released from Mycobacterial Arabinogalactan by Endogenous Arabinanase: Identification of Distinctive and Novel Structural Motifs"
     
137. L. Shi, S. Berg, A. Lee, J. S. Spencer, J. Zhang, V. Vissa, M. R. McNeil, K. H. Khoo and D. Chatterjee  (2006)  J Biol Chem  281(28), 19512-19526  "The carboxy terminus of EmbC from Mycobacterium smegmatis mediates chain length extension of the Arabinan in lipoarabinomannan"
     
138. Terada M, Khoo KH, Inoue R, Chen CI, Yamada K, Sakaguchi H, Kadowaki N, Ma BY, Oka S, Kawasaki T, Kawasaki N  (2005)  The Journal of biological chemistry  280(12), 10897-10913  "Characterization of oligosaccharide ligands expressed on SW1116 cells recognized by mannan-binding protein. A highly fucosylated polylactosamine type N-glycan."
     
139. Chow LP, Chiu LL, Khoo KH, Peng HJ, Yang SY, Huang SW, Su SN  (2005)  The FEBS journal  272(24), 6218-6227  "Purification and structural analysis of the novel glycoprotein allergen Cyn d 24, a pathogenesis-related protein PR-1, from Bermuda grass pollen."
     
140. Chung TL, Hsiao HH, Yeh YY, Shia HL, Chen YL, Liang PH, Wang AH, Khoo KH, Shoei-Lung Li S  (2004)  The Journal of biological chemistry  279(38), 39653-39662  "In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides."
     
141. Kinoshita-Toyoda A, Yamada S, Haslam SM, Khoo KH, Sugiura M, Morris HR, Dell A, Sugahara K  (2004)  Biochemistry  43(34), 11063-11074  "Structural determination of five novel tetrasaccharides containing 3-O-sulfated D-glucuronic acid and two rare oligosaccharides containing a beta-D-glucose branch isolated from squid cartilage chondroitin sulfate E."
     
142. Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH  (2004)  Bioorganic & medicinal chemistry  12(21), 5595-5601  "Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides."
     
143. Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D  (2004)  The Journal of biological chemistry  279(39), 41227-41239  "Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis."
     
144. Suzuki N, Khoo KH, Chen CM, Chen HC, Lee YC  (2003)  The Journal of biological chemistry  278(47), 46293-46306  "N-glycan structures of pigeon IgG: a major serum glycoprotein containing Galalpha1-4 Gal termini.."
     
145. Takahashi N, Masuda K, Hiraki K, Yoshihara K, Huang HH, Khoo KH, Kato K  (2003)  European journal of biochemistry / FEBS  270(12), 2627-2632  "N-Glycan structures of squid rhodopsin."
     
146. Lee CL, Hsiao HH, Lin CW, Wu SP, Huang SY, Wu CY, Wang AH, Khoo KH  (2003)  Proteomics  3(12), 2472-2486  "Strategic shotgun proteomics approach for efficient construction of an expression map of targeted protein families in hepatoma cell lines."
     
147. Zhang N, Torrelles JB, McNeil MR, Escuyer VE, Khoo KH, Brennan PJ, Chatterjee D  (2003)  Molecular microbiology  50(1), 69-76  "The Emb proteins of mycobacteria direct arabinosylation of lipoarabinomannan and arabinogalactan via an N-terminal recognition region and a C-terminal synthetic region."
     
148. Juan HF, Lin JY, Chang WH, Wu CY, Pan TL, Tseng MJ, Khoo KH, Chen ST  (2002)  Electrophoresis  23(15), 2490-2504  "Biomic study of human myeloid leukemia cells differentiation to macrophages using DNA array, proteomic, and bioinformatic analytical methods."
     
149. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH  (2002)  Bioorganic & medicinal chemistry  10(4), 1057-1062  "Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities."
     
150. Khoo KH, Huang HH, Lee KM  (2001)  Glycobiology  11(2), 149-63  "Characteristic structural features of schistosome cercarial N-glycans: expression of Lewis X and core xylosylation."
     
151. K. H. Khoo, A. Dell  (2001)  Adv Exp Med Biol  491, 185-205  "Glycoconjugates from parasitic helminths: structure diversity and immunobiological implications"
     
152. Liao HF, Chou CJ, Wu SH, Khoo KH, Chen CF, Wang SY  (2001)  Anti-cancer drugs  12(10), 841-6  "Isolation and characterization of an active compound from black soybean [Glycine max (L.) Merr.] and its effect on proliferation and differentiation of human leukemic U937 cells."
     
153. Suzuki N, Khoo KH, Chen HC, Johnson JR, Lee YC  (2001)  The Journal of biological chemistry  276(26), 23221-9  "Isolation and characterization of major glycoproteins of pigeon egg white: ubiquitous presence of unique N-glycans containing Galalpha1-4Gal."
     
154. Takahashi N, Khoo KH, Suzuki N, Johnson JR, Lee YC  (2001)  The Journal of biological chemistry  276(26), 23230-23239  "N-glycan structures from the major glycoproteins of pigeon egg white: predominance of terminal Galalpha(1)Gal."
     
155. Huang HH, Tsai PL, Khoo KH  (2001)  Glycobiology  11(5), 395-406  "Selective expression of different fucosylated epitopes on two distinct sets of Schistosoma mansoni cercarial O-glycans: identification of a novel core type and Lewis X structure."
     
156. Brown JR, Field RA, Barker A, Guy M, Grewal R, Khoo KH, Brennan PJ, Besra GS, Chatterjec D  (2001)  Bioorganic & medicinal chemistry  9(4), 815-24  "Synthetic mannosides act as acceptors for mycobacterial alpha1-6 mannosyltransferase."
     
157. Escuyer VE, Lety MA, Torrelles JB, Khoo KH, Tang JB, Rithner CD, Frehel C, McNeil MR, Brennan PJ, Chatterjee D  (2001)  The Journal of biological chemistry  276(52), 48854-62  "The role of the embA and embB gene products in the biosynthesis of the terminal hexaarabinofuranosyl motif of Mycobacterium smegmatis arabinogalactan."
     
158. Chatterjee D, Khoo KH  (2001)  CELLULAR AND MOLECULAR LIFE SCIENCES  58(14), 2018-42  "The surface glycopeptidolipids of mycobacteria: structures and biological properties."
     
159. Khoo KH, Tang JB, Chatterjee D  (2001)  The Journal of biological chemistry  276(6), 3863-71  "Variation in mannose-capped terminal arabinan motifs of lipoarabinomannans from clinical isolates of Mycobacterium tuberculosis and Mycobacterium avium complex."
     
160. Chang T, Kuo MC, Khoo KH, Inoue S, Inoue Y  (2000)  The Journal of biological chemistry  275(1), 129-34  "Developmentally regulated expression of a peptide:N-glycanase during germination of rice seeds (Oryza sativa) and its purification and characterization."
     
161. Hwa KY, Khoo KH  (2000)  Molecular and biochemical parasitology  111(1), 173-84  "Structural analysis of the asparagine-linked glycans from the procyclic Trypanosoma brucei and its glycosylation mutants resistant to Concanavalin A killing."
     
162. Khoo KH, Jarboe E, Barker A, Torrelles J, Kuo CW, Chatterjee D  (1999)  The Journal of biological chemistry  274(14), 9778-85  "Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex."
     
163. Cheng MC, Wang KT, Inoue S, Inoue Y, Khoo KH, Wu SH  (1999)  Analytical biochemistry  267(2), 287-93  "Controlled acid hydrolysis of colominic acid under microwave irradiation."
     
164. Dell A, Haslam SM, Morris HR, Khoo KH  (1999)  Biochimica et Biophysica Acta-Molecular Basis of Disease  1455(2-3), 353-362  "Immunogenic glycoconjugates implicated in parasitic nematode diseases."
     
165. Hwa KY, Acosta-Serrano A, Khoo KH, Pearson T, Englund PT  (1999)  Glycobiology  9(2), 181-90  "Protein glycosylation mutants of procyclic Trypanosoma brucei: defects in the asparagine-glycosylation pathway."
     
166. Cheng MC, Lin CH, Khoo K.H, Wu SH  (1999)  Angew Chem Int Edit  38(5), 686-689  "Regioselective lactonization of alpha-(2 -> 8)-trisialic acid."
     
167. Ueoka C, Nadanaka S, Seno N, Khoo KH, Sugahara K  (1999)  Glycoconjugate journal  16(6), 291-305  "Structural determination of novel tetra- and hexasaccharide sequences isolated from chondroitin sulfate H (oversulfated dermatan sulfate) of hagfish notochord."
     
168. Schaeffer ML, Khoo KH, Besra GS, Chatterjee D, Brennan PJ, Belisle JT, Inamine JM  (1999)  The Journal of biological chemistry  274(44), 31625-31  "The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis."
     
169. Chatterjee D, Khoo KH  (1998)  Glycobiology  8(2), 113-120  "Mycobacterial lipoarabinomannan: an extraordinary lipoheteroglycan with profound physiological effects."
     
170. Haslam SM, Khoo KH, Houston KM, Harnett W, Morris HR, Dell A  (1997)  Molecular and biochemical parasitology  85(1), 53-66  "Characterisation of the phosphorylcholine-containing N-linked oligosaccharides in the excretory-secretory 62 kDa glycoprotein of Acanthocheilonema viteae."
     
171. Xin Y, Lee RE, Scherman MS, Khoo KH, Besra GS, Brennan PJ, McNeil M  (1997)  Biochimica et Biophysica Acta-General Subjects  1335(3), 231-4  "Characterization of the in vitro synthesized arabinan of mycobacterial cell walls."
     
172. Draper P, Khoo KH, Chatterjee D, Dell A, Morris HR  (1997)  The Biochemical journal  327 ( Pt 2), 519-25  "Galactosamine in walls of slow-growing mycobacteria."
     
173. Khoo KH, Chatterjee D, Caulfield JP, Morris HR, Dell A  (1997)  Glycobiology  7(5), 653-61  "Structural characterization of glycophingolipids from the eggs of Schistosoma mansoni and Schistosoma japonicum."
     
174. Khoo KH, Nieto A, Morris HR, Dell A  (1997)  Molecular and biochemical parasitology  86(2), 237-48  "Structural characterization of the N-glycans from Echinococcus granulosus hydatid cyst membrane and protoscoleces."
     
175. Khoo KH, Chatterjee D, Caulfield JP, Morris HR, Dell A  (1997)  Glycobiology  7(5), 663-677  "Structural mapping of the glycans from the egg glycoproteins of Schistosoma mansoni and Schistosoma japonicum: identification of novel core structures and terminal sequences."
     
176. Khoo KH, Suzuki R, Dell A, Morris HR, McNeil MR, Brennan PJ, Besra GS  (1996)  Biochemistry  35(36), 11812-9  "Chemistry of the lyxose-containing mycobacteriophage receptors of Mycobacterium phlei/Mycobacterium smegmatis."
     
177. Dobos KM, Khoo KH, Swiderek KM, Brennan PJ, Belisle JT  (1996)  Journal of bacteriology  178(9), 2498-506  "Definition of the full extent of glycosylation of the 45-kilodalton glycoprotein of Mycobacterium tuberculosis."
     
178. Khoo KH, Chatterjee D, Dell A, Morris HR, Brennan PJ, Draper P  (1996)  The Journal of biological chemistry  271(21), 12333-42  "Novel O-methylated terminal glucuronic acid characterizes the polar glycopeptidolipids of Mycobacterium habana strain TMC 5135."
     
179. Taguchi T, Iwasaki M, Muto Y, Kitajima K, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y  (1996)  EUROPEAN JOURNAL OF BIOCHEMISTRY  238(2), 357-67  "Occurrence and structural analysis of highly sulfated multiantennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis."
     
180. Khoo KH, Douglas E, Azadi P, Inamine JM, Besra GS, Mikusova K, Brennan PJ, Chatterjee D  (1996)  The Journal of biological chemistry  271(45), 28682-90  "Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol."
     
181. Besra GS, Khoo KH, McNeil MR, Dell A, Morris HR, Brennan PJ  (1995)  Biochemistry  34(13), 4257-66  "A new interpretation of the structure of the mycolyl-arabinogalactan complex of Mycobacterium tuberculosis as revealed through characterization of oligoglycosylalditol fragments by fast-atom bombardment mass spectrometry and 1H nuclear magnetic resonance spectroscopy."
     
182. Taguchi T, Kitajima K, Muto Y, Inoue S, Khoo KH, Morris HR, Dell A, Wallace RA, Selman K, Inoue Y  (1995)  Glycobiology  5(6), 611-24  "A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel penta-antennary N-glycan chains with a bisecting N-acetylglucosaminyl residue."
     
183. Khoo KH, Sarda S, Xu X, Caulfield JP, McNeil MR, Homans SW, Morris HR, Dell A  (1995)  The Journal of biological chemistry  270(29), 17114-23  "A unique multifucosylated -3GalNAc beta 1-->4GlcNAc beta 1-->3Gal alpha 1- motif constitutes the repeating unit of the complex O-glycans derived from the cercarial glycocalyx of Schistosoma mansoni."
     
184. Dobos KM, Swiderek K, Khoo KH, Brennan PJ, Belisle JT  (1995)  Infection and immunity  63(8), 2846-53  "Evidence for glycosylation sites on the 45-kilodalton glycoprotein of Mycobacterium tuberculosis."
     
185. Sjoberg ER, Chammas R, Ozawa H, Kawashima I, Khoo KH, Morris HR, Dell A, Tai T, Varki A  (1995)  The Journal of biological chemistry  270(7), 2921-30  "Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole."
     
186. Song Y, Kitajima K, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y  (1995)  Glycobiology  5(2), 207-18  "Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification."
     
187. Khoo KH, Dell A, Morris HR, Brennan PJ, Chatterjee D  (1995)  The Journal of biological chemistry  270(21), 12380-9  "Inositol phosphate capping of the nonreducing termini of lipoarabinomannan from rapidly growing strains of Mycobacterium."
     
188. Khoo KH, Dell A, Morris HR, Brennan PJ, Chatterjee D  (1995)  Glycobiology  5(1), 117-27  "Structural definition of acylated phosphatidylinositol mannosides from Mycobacterium tuberculosis: definition of a common anchor for lipomannan and lipoarabinomannan."
     
189. Khoo KH, Suzuki R, Morris HR, Dell A, Brennan PJ, Besra GS  (1995)  Carbohydrate research  276(2), 449-55  "Structural definition of the glycopeptidolipids and the pyruvylated, glycosylated acyltrehalose from Mycobacterium butyricum."
     
190. Yamada S, Oyama M, Kinugasa H, Nakagawa T, Kawasaki T, Nagasawa S, Khoo KH, Morris HR, Dell A, Sugahara K  (1995)  Glycobiology  5(3), 335-41  "The sulphated carbohydrate-protein linkage region isolated from chondroitin 4-sulphate chains of inter-alpha-trypsin inhibitor in human plasma."
     
191. Besra GS, Gurcha SS, Khoo KH, Morris HR, Dell A, Hamid ME, Minnikin DE, Goodfellow M, Brennan PJ  (1994)  Zentralblatt fur Bakteriologie-International Journal of Medical Microbiology Virology Parasitology and Infectious Diseases  281(4), 415-432  "Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria."
     
192. Sugahara K, Takemura Y, Sugiura M, Kohno Y, Yoshida K, Takeda K, Khoo KH, Morris HR, Dell A  (1994)  Carbohydrate research  255, 165-82  "Chondroitinase ABC-resistant sulfated trisaccharides isolated from digests of chondroitin/dermatan sulfate chains."
     
193. Dell A, Reason AJ, Khoo KH, Panico M, McDowell RA, Morris HR  (1994)  Methods in enzymology  230, 108-32  "Mass spectrometry of carbohydrate-containing biopolymers."
     
194. Besra GS, Khoo KH, Belisle JT, McNeil MR, Morris HR, Dell A, Brennan PJ  (1994)  Carbohydrate research  251, 99-114  "New pyruvylated, glycosylated acyltrehaloses from Mycobacterium smegmatis strains, and their implications for phage resistance in mycobacteria."
     
195. Taguchi T, Seko A, Kitajima K, Muto Y, Inoue S, Khoo KH, Morris HR, Dell A, Inoue Y  (1994)  The Journal of biological chemistry  269(12), 8762-71  "Structural studies of a novel type of pentaantennary large glycan unit in the fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of Oryzias latipes."
     
196. Sugahara K, Tohno-oka R, Yamada S, Khoo KH, Morris HR, Dell A  (1994)  Glycobiology  4(4), 535-44  "Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substrates."
     
197. Yamada S, Sakamoto K, Tsuda H, Yoshida K, Sugahara K, Khoo KH, Morris HR, Dell A  (1994)  Glycobiology  4(1), 69-78  "Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates."
     
198. Khoo KH, Morris HR, McDowell RA, Dell A, Maccarana M, Lindahl U  (1993)  Carbohydrate research  244(2), 205-223  "FABMS/derivatisation strategies for the analysis of heparin-derived oligosaccharides."
     
199. Besra GS, McNeil MR, Rivoire B, Khoo KH, Morris HR, Dell A, Brennan PJ  (1993)  Biochemistry  32(1), 347-55  "Further structural definition of a new family of glycopeptidolipids from Mycobacterium xenopi."
     
200. Chatterjee D, Khoo KH, McNeil MR, Dell A, Morris HR, Brennan PJ  (1993)  Glycobiology  3(5), 497-506  "Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry."
     
201. Taguchi T, Seko A, Kitajima K, Inoue S, Iwamatsu T, Khoo KH, Morris HR, Dell A, Inoue Y  (1993)  The Journal of biological chemistry  268(4), 2353-62  "Structural studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian Medaka fish, Oryzias melastigma."
     
202. Yamada S, Yoshida K, Sugiura M, Sugahara K, Khoo KH, Morris HR, Dell A  (1993)  The Journal of biological chemistry  268(7), 4780-7  "Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin."
     
203. Stephens L, Radenberg T, Thiel U, Vogel G, Khoo KH, Dell A, Jackson TR, Hawkins PT, Mayr GW  (1993)  The Journal of biological chemistry  268(6), 4009-15  "The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s)."
     
204. Besra GS, McNeil MR, Khoo KH, Dell A, Morris HR, Brennan PJ  (1993)  Biochemistry  32(47), 12705-14  "Trehalose-containing lipooligosaccharides of Mycobacterium gordonae: presence of a mono-O-methyltetra-O-acyltrehalose "core" and branching in the oligosaccharide backbone."
     
205. Woodward JR, Craik D, Dell A, Khoo KH, Munro SL, Clarke AE, Bacic A  (1992)  Glycobiology  2(3), 241-50  "Structural analysis of the N-linked glycan chains from a stylar glycoprotein associated with expression of self-incompatibility in Nicotiana alata."
     
206. Sjoberg ER, Manzi AE, Khoo KH, Dell A, Varki A  (1992)  The Journal of biological chemistry  267(23), 16200-11  "Structural and immunological characterization of O-acetylated GD2. Evidence that GD2 is an acceptor for ganglioside O-acetyltransferase in human melanoma cells."
     
207. Khoo KH, Maizels RM, Page AP, Taylor GW, Rendell NB, Dell A  (1991)  Glycobiology  1(2), 163-71  "Characterization of nematode glycoproteins: the major O-glycans of Toxocara excretory-secretory antigens are O-methylated trisaccharides."
     
208. Williams DJ, Radding JA, Dell A, Khoo KH, Rogers ME, Richards FF, Armstrong MY  (1991)  Journal of Protozoology  38(4), 427-37  "Glucan synthesis in Pneumocystis carinii."
     
209. Khoo KH, Dell A  (1990)  Glycobiology  1(1), 83-91  "Assignment of anomeric configurations of pyranose sugars in oligosaccharides using a sensitive FAB-MS strategy."