Research

Please visit the website (http://idv.sinica.edu.tw/chunhung) for the details. Research in Lin’s lab involves multi-disciplinary areas including glycobiology, enzymology, synthetic chemistry and biophysics. Special emphasis is stressed to develop bioorganic and biochemical approaches for investigating the carbohydrate-related enzymes at molecular level, particularly in association with infectious diseases and cancers. Development of enzyme inhibitors has been carried out to study how small molecules interact with proteins and in turns, understand how potent enzyme inhibitors intervene in pathogenesis. Great success has been made to establish practical activity assays with high sensitivity and throughput, paving the way for discovery of the most potent glycosidase inhibitor to date (Ki = 0.46 pM).

Degrees and Positions Held
Positions Held
  • 2007 – present   Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2017 – 2020   Director, Department of Academic Affairs and Instrument Service, Academia Sinica
  • 2014   Outstanding Research Award, Ministry of Science and Technology
  • 2014 – 2017   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 2011   Investigator Award of Academia Sinica, Academia Sinica
  • 2010   Young Investigator Award, Academia Sinica
  • 2010   Young Scholar Award, Tien-De Li Biomedical Foundation
  • 2008   The Top Ten Rising Stars in Taiwan, Selected by the Central NEws Agency of Taiwan
  • 2006   Excellent Young Scholar Award, The Chemical Society Located at Taipei
  • 2005   Mentor Recognition Award, University of California, San Diego
  • 2002 – 2004   Secretary-General, Taiwan Biophysics Society
  • 2002 – 2007   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1998   Heritage Prize and Fellowship, Li’s Foundation
  • 1998 – 2002   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1993 – 1994   Glaxo Fellowship, Scripps Research Institute
Degrees
  • 1995 – 1997   Research Fellow, Harvard Medical School
  • 1990 – 1995   Ph.D., Chemistry, Scripps Research Institute.
  • 1986 – 1990   B.S., Chemistry, National Taiwan University.
Selected Publications
Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium.
Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KT*, Lin CH*
Commun Biol. (2020)
Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes.
Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, Lin CH*
J Med Chem. (2020)
Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence.
Jan HM, Chen YC, Shih YY, Huang YC, Tu Z, Ingle AB, Liu SW, Wu MS, Gervay-Hague J, Mong KKT, Chen YR, Lin CH
Chemical Science (2016)
Development of fucosyltransferase and fucosidase inhibitors.
Tu Z, Lin YN, Lin CH
Chemical Society Reviews (2013)
In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method.
Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, Lin CH
Angew Chem Int Ed. (2012)
Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range.
H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin, A.H.-J.Wang
Angew Chem Int Ed. (2010)
Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells.
Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin
Proc. Natl. Acad. Sci. USA (2009)
Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.
H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin
J Biol Chem (2007)
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.
C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin
EMBO J (2006)
Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.
C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin
Angew Chem Int Ed. (2003)
Publications List
  1. Lai ZS, Yeh TK, Chou YC, Hsu T, Lu CT, Kung FC, Hsieh MY, (Lin CH), Chen CT, James Shen CK, Jiaang WT  (2021-01)  Eur J Med Chem.  209, 112938  "Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease."
  2. Verma N, Tu Z, Lu MS, Liu SH, Renata S, Phang R, Liu PK, Ghosh B, (Lin CH)*  (2021-01)  The Journal of Organic Chemistry  86(1), 892-916  "Threshold of Thioglycoside Reactivity Difference Is Critical for Efficient Synthesis of Type I Oligosaccharides by Chemoselective Glycosylation."
  3. Abdu-Allah HHM, Wu SC, (Lin CH), Tseng YY  (2020-12)  European Journal of Medicinal Chemistry  208, 112707  "Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands"
  4. Chen YR, Naresh A, Liang SY, (Lin CH), Chein RJ, Lin HC  (2020-08)  Angewandte Chemie-International Edition  59(32), 13537-13541  "Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis."
  5. Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, (Lin CH)*  (2020-05)  Journal of medicinal chemistry  63(9), 4617-4627  "Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes."
  6. Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KT*, (Lin CH)*  (2020-03)  Communications Biology  3(1), 120  "Cholesteryl alpha-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium."
  7. Hong MH, Lin WH, Weng IC, Hung YH, Chen HL, Chen HY, Chen P, (Lin CH), Yang WY, Liu FT  (2020-01)  Glycobiology  30(1), 36-48  "Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition."
  8. Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, (Lin CH), Liu FT, Chern Y  (2019-08)  Nature communications  10(1), 3473  "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease."
  9. Hsieh FJ, Sotoma S, Lin HH, Cheng CY, Yu TY, Hsieh CL, (Lin CH), Chang HC  (2019-06)  ACS applied materials & interfaces  11(22), 19774-19781  "Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins."
  10. Hsieh FJ, Chen YW, Hui YY, (Lin CH), Chang HC  (2019-05)  Micromachines  10(5), 304  "Quantification and Imaging of Antigens on Cell Surface with Lipid-Encapsulated Fluorescent Nanodiamonds."
  11. Li FY, Weng IC, (Lin CH), Kao MC, Wu MS, Chen HY, Liu FT  (2019-02)  Glycobiology  29(2), 151-162  "Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner."
  12. Chuaboon L, Wongnate T, Punthong P, Kiattisewee C, Lawan N, Hsu CY, (Lin CH), Bornscheuer U, Chaiyen P  (2019-02)  Angewandte Chemie - International Edition  58(8), 2428-2432  "One-Pot Bioconversion of L-Arabinose to L-Ribulose in an Enzymatic Cascade."
  13. Lu YC, Mondal S, Wang CC, (Lin CH), Mong KT  (2019-01)  Chembiochem  20(2), 287-294  "Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1'-Disaccharide Aminoglycosides."
  14. Vinals DF, Kitov PI, Tu Z, Zou C, Cairo CW, (Lin CH), Derda R*  (2019-01)  Peptide Science  111(1), e24097  "Selection of galectin‐3 ligands derived from genetically encoded glycopeptide libraries."
  15. Dashnyam P, Mudududdla R, Hsieh TJ, Lin TC, Lin HY, Chen PY, Hsu CY, (Lin CH)  (2018-11)  Scientific reports  8(1), 16372  "beta-Glucuronidases of opportunistic bacteria are the major contributors to xenobiotic-induced toxicity in the gut."
  16. Yang CY, Chiang HC, Kuo CJ, Hsu CW, Chan SF, Lin ZY, (Lin CH), Chen YT  (2018-04)  ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY  7(7), Q3153-Q3158  "Hepatocellular Carcinoma Diagnosis by Detecting alpha-Fucosidase with a Silicon Nanowire Field-Effect Transistor Biosensor."
  17. Hsieh FJ, Chen YW, Huang YK, Lee HM, (Lin CH), Chang HC  (2018-02)  Analytical chemistry  90(3), 1566-1571  "Correlative Light-Electron Microscopy of Lipid-Encapsulated Fluorescent Nanodiamonds for Nanometric Localization of Cell Surface Antigens."
  18. Chang LL, Hsu WH, Kao MC, Chou CC, Lin CC, Liu CJ, Weng BC, Kuo FC, Kuo CH, Lin MH, Wang CJ, (Lin CH), Wu DC, Huang SK  (2018-02)  Scientific reports  8(1), 3821  "Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases."
  19. Chan YC, Lin HY, Tu Z, Kuo YH, Hsu SD, (Lin CH)  (2018-01)  International journal of molecular sciences  19(2), 392  "Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions."
  20. Bella M, Yan S, Šesták S, Kozmon S, (Lin CH), Mucha J, Koóš M  (2017-11)  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY  2017(41), 6179–6191  "Synthesis of a β-d-Psicofuranosyl Sulfone and Inhibitory-Activity Evaluation Against N-Acetylglucosaminyltransferase I."
  21. Chien CTH, Ho MR, (Lin CH), Hsu STD*  (2017-08)  MOLECULES  22(8), 1357  "Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange."
  22. Hu JC, Feng AW, Chang BY, (Lin CH), Mong KT  (2017-06)  Organic & biomolecular chemistry  15(25), 5345-5356  "A flexible 1,2-cis alpha-glycosylation strategy based on in situ adduct transformation."
  23. Wu SY, Huang JH, Chen WY, Chan YC, (Lin CH), Chen YC, Liu FT, Wu-Hsieh BA  (2017-02)  Frontiers in immunology  8, 48  "Cell Intrinsic Galectin-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation."
  24. Wu JL, Wu HY, Tsai DY, Chiang MF, Chen YJ, Gao S, Lin CC, (Lin CH), Khoo KH, Chen YJ, Lin KI  (2016-08)  Nature communications  7, 12526  "Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells."
  25. Hsieh TJ, Lin HY, Tu Z, Lin TC, Wu SC, Tseng YY, Liu FT, Hsu ST, (Lin CH)  (2016-07)  Scientific reports  6, 29457  "Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors."
  26. Chen YB, Liu SH, Hsieh MT, Chang CS, (Lin CH), Chen CY, Chen PY, Lin HC  (2016-04)  The Journal of organic chemistry  81(7), 3007-3016  "Stereoselective Synthesis of Spiro Bis-C,C-alpha-arylglycosides by Tandem Heck Type C-Glycosylation and Friedel-Crafts Cyclization."
  27. Jan HM, Chen YC, Shih YY, Huang YC, Tu Z, Ingle AB, Liu SW, Wu MS, Gervay-Hague J, Mong KKT, Chen YR, (Lin CH)  (2016)  Chemical Science  7(9), 6208-6216  "Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence"
  28. Tony Mong KK, Shiau KS, Lin YH, Cheng KC, (Lin CH)  (2015-12)  Organic & biomolecular chemistry  13(47), 11550-11560  "A concise synthesis of single components of partially sulfated oligomannans."
  29. Liu CH, Chien CT, (Lin CH), Hsu ST  (2015-10)  Biomolecular NMR assignments  9(2), 427-430  "NMR assignments of the C-terminal domain of human galectin-8."
  30. Bella M, Koos M, (Lin CH)  (2015-09)  Beilstein journal of organic chemistry  11, 1547-1552  "Towards inhibitors of glycosyltransferases: A novel approach to the synthesis of 3-acetamido-3-deoxy-D-psicofuranose derivatives."
  31. Hsu YL, Nandakumar M, Lai HY, Chou TC, Chu CY, (Lin CH), Lo LC  (2015-08)  The Journal of organic chemistry  80(16), 8458-8463  "Development of Activity-Based Probes for Imaging Human alpha-l-Fucosidases in Cells."
  32. Nandakumar M, Hsu YL, Lin JC, Lo C, Lo LC, (Lin CH)  (2015-07)  Chembiochem : a European journal of chemical biology  16(11), 1555-1559  "Detection of Human alpha-L-Fucosidases by a Quinone Methide-Generating Probe: Enhanced Activities in Response to Helicobacter pylori Infection."
  33. Cheng CW, Chou CC, Hsieh HW, Tu Z, (Lin CH), Nycholat C, Fukuda M, Khoo KH  (2015-06)  Analytical chemistry  87(12), 6380-6388  "Efficient Mapping of Sulfated Glycotopes by Negative Ion Mode nanoLC-MS/MS-Based Sulfoglycomic Analysis of Permethylated Glycans."
  34. Hsieh TJ, Lin HY, Tu Z, Huang BS, Wu SC, (Lin CH)*  (2015-05)  PLoS One  10(5), e0125946  "Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc"
  35. Tu Z, Liu PK, Wu MC, (Lin CH)*  (2015-04)  Israel Journal of Chemistry  55(3-4), 325-335  "Expeditious synthesis of orthogonally protected oligosaccharides through consecutive protection and glycosylation steps"
  36. Baráth M, (Lin CH), Tvarošk I, Hirsch J  (2015-02)  CHEMICAL PAPERS  69(2), 348-357  "Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds"
  37. Chou CC, Chiang BY, Lin JC, Pan KT, (Lin CH), Khoo KH*  (2015-01)  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY  26(1), 120-132  "Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein S-glutathionylation"
  38. Lin JC, Chiang BY, Chou CC, Chen TC, Chen YJ, Chen YJ, (Lin CH)  (2015-01)  Molecules  20(1), 1452-1474  "Glutathionylspermidine in the Modification of Protein SH Groups: The Enzymology and Its Application to Study Protein Glutathionylation"
  39. Chen YB, Wang SI, Lin ZP, (Lin CH), Hsieh MT, Lin HC  (2015)  Tetrahedron  71, 350-358  "Stereoselective glycosylation of d-galactals by diethyl phosphorochloridite- and AlCl3-assisted Ferrier rearrangement"
  40. C.-W. Lin, K.-W. Hon, B. Ghosh, P.-H. Li, H.-Y. Lin, P.-H. Chan, Y.-C. Chen, (C.-H. Lin), K.-K. T. Mong*  (2014-09)  Chemistry-An Asian Journal  9(7), 1786-1796  "Synthesis of Oligomeric Mannosides and Their Structure-Binding Relationship with Concanavalin A"
  41. Lin JC, Chou CC, Tu Z, Yeh LF, Wu SC, Khoo KH, (Lin CH)  (2014-08)  Journal of proteome research  13(8), 3523-3529  "Characterization of Protein Serotonylation via Bioorthogonal Labeling and Enrichment."
  42. Ghosh B, Lai YH, Shih YY, Pradhan TK, (Lin CH), Mong KK.  (2013-12)  Chemistry-An Asian Journal  8(12), 3191-3199  "Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties"
  43. Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, (Lin CH), Hsu HY, Wu CY, Wong CH.  (2013-08)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  110(34), 13809-13814  "Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes."
  44. Huang HW, Chen CH, (Lin CH), Wong CH, Lin KI.  (2013-07)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  110(27), 10928-10933  "B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention"
  45. Z. Tu, H.-W. Hsieh, C.-M. Tsai, C.-W. Hsu, S.-G. Wang, K.-J. Wu, K.-I. Lin*, (C.-H. Lin)*  (2013-07)  Chemistry-An Asian Journal  8(7), 1536-1550  "Synthesis and characterization of sulfated Gal-β-1, 3/1,4 -GlcNAc disaccharides through consecutive protection /glycosylation steps"
  46. Lin JC, Chou CC, Gao S, Wu SC, Khoo KH, (Lin CH)  (2013-05)  Chembiochem : a European journal of chemical biology  14(7), 813-817  "An in Vivo Tagging Method Reveals that Ras Undergoes Sustained Activation upon Transglutaminase-Mediated Protein Serotonylation."
  47. Tu Z, Lin YN, (Lin CH)  (2013-05)  Chemical Society reviews  42(10), 4459-4475  "Development of fucosyltransferase and fucosidase inhibitors."
  48. J.-T. Wang, T.-C. Lin, Y.-H. Chen, (C.-H. Lin)* and J.-M. Fang*  (2013-05)  MedChemComm  4(5), 783-791  "Polyhydroxylated pyrrolidine and 2-oxapyrrolizidine as glycosidase inhibitors"
  49. Sue-Ming Chang, Zhijay Tu, Hau-Ming Jan, Jia-Fu Pan and (Chun-Hung Lin)*  (2013-05)  CHEMICAL COMMUNICATIONS  49(39), 4265-4267  "Rapid synthesis of oligomannosides with orthogonally protected monosaccharides"
  50. Z.-P. Lin, F.-F. Wong, Y.-B. Chen, (C.-H. Lin), M.-T. Hsieh, J.-C. Lien, Y.-H. Chou, H.-C. Lin   (2013-05)  Tetrahedron  69(19), 3991-3999  "Regioselective and reductive cleavage of allyl ethers by NaBH4–HOAc"
  51. Z.-P. Lin, F.-F. Wong, Y.-B. Chen, Y.-C. Lin, M. Kimura, K. Kaneko, H. Takayama, J.-B. Wu, (C.-H. Lin),* H.-C. Lin,*  (2013-03)  Tetrahedron  69(11), 2494-2500  "Synthesis of α-2-deoxy-ulosides by Michael addition of hex-1-en-3-ones"
  52. Davis RA, (Lin CH), Gervay-Hague J  (2012-09)  Chemical communications  48(72), 9083-9085  "Chemoenzymatic synthesis of cholesteryl-6-O-tetradecanoyl-alpha-D-glucopyranoside: a product of host cholesterol efflux promoted by Helicobacter pylori."
  53. Yu-Nong Lin, Daniel Stein, Sheng-Wei Lin, Sue-Ming Chang, Ting-Chien Lin, Yu-Ruei Chuang, Jacquelyn Gervay-Hague, Hisashi Narimatsu, (Chun-Hung Lin)*  (2012-06)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  54. Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, (Lin CH)  (2012-06)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  51(24), 5871-5875  "In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method."
  55. Y.-F. Wang, W.-I. Liao, Y.-D. Kuo, S.-Y. Guu, H.-C. Wang, (C.-H. Lin), I.-J. Su, C.-F. Chang  (2012-06)  Future Virology  7(6), 621-633  "Receptor binding surveillance of influenza clinical isolates"
  56. Yang PY, Chen WX, Chang FY, Chen HW, (Lin CH), Hsu YC, Wu JH  (2012-02)  Apoptosis : an international journal on programmed cell death  17(2), 154-163  "HepG2 cells infected with Klebsiella pneumoniae show DNA laddering at apoptotic and necrotic stages."
  57. C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, (C.-H. Lin)*  (2011-10)  ChemBioChem  12(15), 2306-2309  "An Acyloxymethyl Ketone-based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli"
  58. C.-M. Tsai, C.-H. Guan, H.-W. Hsieh, T.-L. Hsu, K.-J. Wu, Z.-J. Tu, (C.-H. Lin)*, K.-I. Lin*  (2011-08)  J Immunol  187(4), 1643-1652  "Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation"
  59. C.-M. Chau, K.-J Liu, (C.-H. Lin)  (2011-07)  BIORESOURCE TECHNOLOGY  102(21), 10136-10138  "Enzymatic synthesis of sialic acid derivatives by immobilized lipase from Candida antarctica"
  60. C.-F. Chang, J.-F. Pan, C.-N. Lin, I.-L. Wu, C.-H. Wong, (C.-H. Lin)*  (2011-07)  Glycobiology  21(7), 895-902  "Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers."
  61. H.-C. Lin, J.-F. Pan, Y.-B. Chen, Z.-P. Lin, (C.-H. Lin)*  (2011-06)  Tetrahedron  67(34), 6362-6368  "Stereoselective glycosylation of endo-glycals by microwave- and AlCl3-assisted catalysis"
  62. Y.-Y. Chen, T.-P. Ko, (C.-H. Lin), W.-H. Chen, A. H.-J. Wang*  (2011-04)  J Struct Biol  175(3), 300-310  "Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance"
  63. C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, (C.-H. Lin), C.-H. Wong, A. H.-J. Wang*  (2011-04)  J Biol Chem  286(16), 14057-14064  "Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251."
  64. W.-I. Liao, Y.-F. Wang, Y.-D. Kuo, Y.-D., (C.-H. Lin), T.-C. Chang I.-J. Su, J.-R. Wang, C.-F. Chang*  (2011-03)  Future Med Chem  3(3), 283-296  "Profiling of influenza viruses by high-throughput carbohydrate membrane array"
  65. P.-H. Pai, H.-J. Wu, (C.-H. Lin)*, A. H.-J. Wang*  (2011-03)  PROTEIN SCIENCE  20(3), 557-566  "Structure and mechanism of E. coli glutathionylspermidine amidase belonging to the family of cysteine, histidine-dependent amidohydrolase/peptodase"
  66. P.-C. Pan, H.-W. Chen, P.-K. Wu, Y.-Y. Wu, (C.-H. Lin), J.-H. Wu*  (2011-02)  Exp Biol Med  236(2), 219-226  "Mutation in fucose synthesis gene of Klebsiella pneumonia affects capsule composition and virulence in mice"
  67. Shih TL, Liang MT, Wu KD, (Lin CH)  (2011)  Carbohydrate Research  346(2), 183-190  "Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors."
  68. Lammerts van Bueren A, Popat SD, (Lin CH), Davies GJ  (2010-09)  CHEMBIOCHEM  11(14), 1971-1974  "Structural and thermodynamic analyses of alpha-L-fucosidase inhibitors."
  69. Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, Wang AH, (Lin CH)  (2010-08)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(33), 25345-25353  "Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION."
  70. Hui-Chang Lin, Yen-Bo Chen, Zi-Ping Lin, Fung Fuh Wong, (Chun-Hung Lin) and Shao-Kai Lin  (2010-07)  Tetrahedron  66(27-28), 5229-5234  "Synthesis of 1,7-dioxaspiro[5.5]undecanes and 1-oxa-7-thiaspiro[5.5]undecanes from exo-glycal"
  71. Ho CW, Popat SD, Liu TW, Tsai KC, Ho MJ, Chen WH, Yang AS, (Lin CH).  (2010-05)  ACS Chem. Biol.  5(5), 489-497  "Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-β-Hexosaminidase Inhibitors"
  72. Ying-Yin Chen, Tzu-Ping Ko, Wei-Hung Chen, Li-Ping Lo, (Chun-Hung Lin), Andrew H.-J. Wang  (2010-01)  Journal of Structural Biology  169(1), 25-35  "Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism"
  73. H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, (C.-H Lin), A.H.-J.Wang  (2010-01)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  49(2), 337-340  "Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range"
  74. Hui-Chang Lin, Hsu-Hsuan Wu, Zi-Ping Lin, Chih-Yuan Lin, (Chun-Hung Lin), Kun-Lung Chen, Fung Fuh Wong  (2009-12)  Tetrahedron Letters  50(52), 7327-7329  "Microwave-assisted stereoselective α-2-deoxyglycosylation of hex-1-en-3-uloses"
  75. Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin  (2009-08)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  106(34), 14581-14586  "Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells"
  76. S.-W. Liu, C.-S. Chen, S.-S. Chang, K.-K. Mong, (C.-H. Lin), C.-W. Chang, C.-Y. Tang, Y.-K. Li  (2009-01)  Biochemistry  48(1), 110-120  "Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism. "
  77. C.-S. Shi, G-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu   (2008-11)  Blood  112(9), 3661-3670.  "Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccahride-induced inflammatory response"
  78. D. B. Stein, Yu Nong. Lin, Chun Hung Lin*  (2008-10)  Adv. Synth. Catal.  350(14-15), 2313-2321  "Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens"
  79. Hsu HJ, Tsai KC, Sun YK, Chang HJ, Huang YJ, Yu HM, (Lin CH), Mao SS, Yang AS  (2008-05)  The Journal of biological chemistry  283(18), 12343-12353  "Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling."
  80. Chiou-Yueh Yeh, Chun-Nan Lin, Chuan-Fa Chang, Chun-Hung Lin, Huei-Ting Lien, Jen-Yang Chen, and Jean-San Chia  (2008)  Infection and Immunity  76(3), 1170-1178  "C-Terminal Repeats of Clostridium difficile Toxin A Induce Production of Chemokine and Adhesion Molecules in Endothelial Cells and Promote Migration of Leukocytes"
  81. Y. M. Shao, W. B. Yang, T. H. Kuo, K. C. Tsai, C. H. Lin, A. S. Yang, P. H. Liang and C. H. Wong  (2008)  Bioorganic & medicinal chemistry  16(8), 4652-4660  "Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease"
  82. T. L. Shih, R. Y. Yang, S. T. Li, C. F. Chiang and C. H. Lin  (2007)  J Org Chem  72(11), 4258-4261  "Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from D-(-)-Quinic Acid as Potent Glycosidase Inhibitors"
  83. H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin  (2007)  J Biol Chem  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design"
  84. Y. M. Shao, W. B. Yang, H. P. Peng, M. F. Hsu, K. C. Tsai, T. H. Kuo, A. H. Wang, P. H. Liang, C. H. Lin, A. S. Yang and C. H. Wong  (2007)  Chembiochem  8(14), 1654-1657  "Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors"
  85. J. Yin, A. Hashimoto, M. Izawa, K. Miyazaki, G.Y Chen, H. Takematsu, Y. Kozutsumi, A. Suzuki, K. Furuhata, FL Cheng, CH Lin, C. Sato, K. Kitajima and R. Kannagi  (2006-03)  Cancer Res  66(6), 2937-2945  "Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells"
  86. S. W. Lin, J. R. Li, T. M. Yuan and C. H. Lin  (2006)  Biochemistry  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."
  87. S. C. Chen, Y. C. Chang, C. H. Lin, C. H. Lin and S. H. Liaw  (2006)  J. Biol. Chem  281, 7605-7613  "Crystal Structure of a Bifunctional Deaminase and Reductase from Bacillus Substilus Involved in Riboflavin Biosynthsis"
  88. C. W. Ho, C. F. Chang, Y. N. Lin, H. T. Lee, Y. T. Wu, C. Y. Wu, S. W. Liu, Y. K. Li, C. H. Lin  (2006)  Biochemistry  45, 5695-5702  "Discovery of Different Types of Inhibition between the Human and Thermotoga maritime alpha-Fucosidases by Fuconojirimycin-based Derivatives."
  89. C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin  (2006)  EMBO J  25(24), 5970-5982  "Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase."
  90. C. H. Chien, C. H. Tsai, C. H. Lin, C. Y. Chou and X. Chen  (2006)  Biochemistry  45, 7006-7012  "Identification of hydrophobic residues critical for DPP-IV dimerization"
  91. S. J. Hsu, H. C. Lin and C. H. Lin  (2006)  Carbohydrate Research  341, 1428-1437  "Inter- and Intramolecular Glycosylation of exo-Glycals Promoted by Metallic Lewis Acid"
  92. H. J. Lee, Y. S. Chen, C. Y. Chou, CH. Chien, C. H. Lin, G. G. Chang and X. Chen  (2006)  J. Biol. Chem  281, 38653-38662  "Investigation of the dimer interface and substrate specificity of prolyl dipeptiase DPP8"
  93. C. K. Chang, S. C. Sue, T. H. Yu, C. M. Hsieh, C. K. Tsai, Y.C. Chiang, S. J Lee, H.H. Hsiao, W. J. Wu, W. L. Chang, C. H. Lin , T. H. Huang  (2006)  J. Biomed. Sci  13, 59-72  "Modular Organization of SARS Coronavirus Nucleocapsid Protein"
  94. Y. S. E. Cheng, K. H. Lo, H. H. Hsu, Y.M. Shao, W. B.Yang, C. H. Lin, C. H. Wong  (2006)  J. Virol. Methods  137, 82-87  "Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in E. coli"
  95. H. C. Lin, W. P. Du, C. C. Chang and C. H. Lin  (2005)  Tetrahedron Letters  46, 5071-5076  "Different Reaction Routes Found in Acid-Catalyzed Glycosylation of endo- and exo-Glycals: Competition between Ferrier Rearrangement and Protonation"
  96. J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W.-B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu and C. H. Wong  (2005)  J. Med. Chem  48, 4469-4473  "Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease"
  97. C. H. Lin, H. C. Lin and W. B. Yang  (2005)  Current Topics in Medicinal Chemistry  5, 1431-1457  "exo-Glycal chemistry: general aspects and synthetic applications for biochemical use."
  98. H. C. Lin, C. C. Chang, J. Y. Chen and C. H. Lin  (2005)  Tetrahedron: Asymmetry  16, 297-301  "Stereoselective glycosylation of exo-glycals by microwave-assisted Ferrier rearrangement"
  99. H.H. Huang, H.K. Liao, Y.J. Chen, T.S. Hwang, YiHan Lin, C.H. Lin  (2005)  Journal of the American Society for Mass Spectrometry  16, 324-332  "Structural Characterization of Sialic Acid Synthase by Electrospray Mass Spectrometry: A Tetrameric Enzyme Composed of Dimeric Dimers"
  100. G. T. Fan, Y. S. Pan, K. C. Lu, Y. P. Cheng, C. H. Wong, W. C. Lin, C. H. Lin, J. M. Fang and C. C. Lin  (2005)  Tetrahedron  61, 1855-1862  "Synthesis of a-Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes"
  101. C. F. Teo, T. S. Hwang, P. H. Chen, C. H. Hung, H. S. Gao, L. S. Chang and C. H. Lin  (2005)  Adv. Synth. Catal  347, 967-972  "Synthesis of Sialyl TN Glycopeptides― Enzymatic Sialylation by alpha2,6-Sialyltransferase from Photobacterium damsela"
  102. C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong and C. H. Lin  (2004)  Chemistry & Biology  11, 1301-1306  "Discovery of Picomolar Slow Tight-Binding Inhibitors of alpha-Fucosidase"
  103. H. Y. Hsu, K. F. Hua, C. C. Lin, C. H. Lin, J. Hsu and C. H. Wong  (2004)  J. Immunol  173, 5989-5999  "Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling pathways"
  104. M. C. Cheng, C. H. Lin, H. J. Lin, Y. P. Yu and S. H. Wu  (2004)  Glycobiology  14, 147-155  "Hydrolysis, lactonization, and identification of alpha(2 --> 8)/alpha(2 --> 9) alternatively linked tri-, tetra-, and polysialic acids"
  105. H. S. Chen, Y. F. Tsai, S. Lin, K. H. Khoo, C. H. Wong and C. H. Lin  (2004)  Bioorganic & Medicinal Chemistry  12, 5595-5601  "Studies on the Immuno-modulating and Anti-tumor Activities of Ganoderma lucidum (Reishi) Polysaccharides"
  106. C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin  (2003)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  42, 4661-4664  "Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors"
  107. The Y.-J. Chen, T.-S. Hwang, X.-H. Hwnag, H.-K. Liao, C.-H. Lin  (2003)  The Proceedings of the International Symposium on Biomolecular Chemistry 2003  96-99  "Sialic Acid Synthase from Escherichia coli Structural Characterization by Mass Spectrometry"
  108. H. C. Lin, W. B. Yang, Y. F. Gu, C. Y. Chen, C. Y. Wu and C. H. Lin  (2003)  Org Lett  5, 1087-1089  "Stereoselective glycosylation of exo-glycals accelerated by Ferrier-type rearrangement"
  109. C.-F. Chang, W.-B. Yang, C.-C. Chang, C.-H. Lin  (2002)  Tetrahedron Letters  43, 6515-6519  "Inter- and Intramolecular alcohol additions of exo-Glycals"
  110. W. B. Yang, Y. Y. Yang, Y. F. Gu, S. H. Wang, C. C. Chang and C. H. Lin  (2002)  J Org Chem  67, 3773-3782  "Stereochemistry in the synthesis and reaction of exo-glycals"
  111. T. S. Hwang, C. H. Hung, C. F. Teo, G. T. Chen, L. S. Chang, S. F. Chen, Y. J. Chen and C. H. Lin  (2002)  Biochem Biophys Res Commun  295, 167-173  "Structural characterization of Escherichia coli sialic acid synthase"
  112. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, (Lin CH)  (2002)  Bioorganic & medicinal chemistry  10(4), 1057-1062  "Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities."
  113. W.-B. Yang, Sachindra S. Patil, C.-H. Tsai, C.-H. Lin, J.-M. Fang  (2002)  Tetrahedron Letters  58, 253-259  "The synthesis of l-gulose and l-xylose from d-gluconolactone"
  114. Y. P. Yu, M. C. Cheng, H. R. Lin, C. H. Lin and S. H. Wu  (2001)  J Org Chem  66, 5248-5251  "Acid-catalyzed hydrolysis and lactonization of alpha2,8-linked oligosialic acids"
  115. C. H. Lin, C. C. Lin  (2001)  Adv Exp Med Biol  491, 215-230  "Enzymatic and chemical approaches for the synthesis of sialyl glycoconjugates"
  116. W.-B. Yang, C.-F. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin.  (2001)  Tetrahedron Letters  42, 4567-4660  "Expeditious Synthesis of C-Glycosyl Conjugated Dienes and Aldehydes from Sugar Lactones"
  117. W.-B. Yang, T.-I. Wu, C.-C. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin.  (2001)  Tetrahedron Letters  42, 6907-6910  "Facile Synthesis of Conjugated exo-Glycals "
  118. M. D. Burkart, M. Izumi, E. Chapman, C. H. Lin and C. H. Wong  (2000)  J Org Chem  65, 5565-5574  "Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides"
  119. Y.-Y. Yang, W.-B. Yang, C.-F. Teo, C.-H. Lin  (2000)  Synlett  2000(11), 1634-1636  "Regioselective Deprotection of tert-Butyldimethylsilyl Ethers by Boron Trichloride"
  120. M. C. Cheng, C. H. Lin, H. Y. Wang, H. R. Lin and S. H. Wu  (2000)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  39, 772-776  "Regioselective Lactonization of Tetrasialic Acid"
  121. W. B. Yang  (2000)  Tetrahedron Lett  41, 2569-2572  "The expeditious preparation and reactivity of some protected forms of gluconolactone."
  122. M. C. Cheng, C. H. Lin, K. H. Khoo and S. H. Wu  (1999)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  38, 686-689  "Regioselective Lactonization of α-(2,8)-Trisialic Acid"
  123. C. H. Lin, S. Chen, D. S. Kwon, J. K. Coward and C. T. Walsh  (1997)  Chem Biol  4, 859-866  "Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase"
  124. I.-S. Park, C.-H. Lin, C. T. Walsh  (1997)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  94, 10040-10044  "Bacterial Resistance to Vancomycin: Overproduction, Purification, and Characterizationof VanC2 from Enterococcus casseliflavus as a d-Ala-d-Ser ligase."
  125. D. S. Kwon, C.-H. Lin, S. Chen, J. K. Coward, C. T. Walsh, J. M. Borlinger, Jr.  (1997)  J. Biol. Chem.  272, 2429-2436  "Dissection of Glutathionylspermidine Synthetase/Amidase from Escherichia coli into Autonomously Folding and Functional Synthetase and Amidase Domains."
  126. C. H. Lin, D. S. Kwon, J. M. Bollinger, Jr. and C. T. Walsh  (1997)  Biochemistry  36, 14930-14938  "Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli"
  127. S. Chen, C.-H. Lin, C. T. Walsh, J.K. Coward  (1997)  Bioorg. Med. Chem. Lett.  7, 505-510  "Novel Inhibitors of Trypanothione Biosynthesis: Synthesis and Evaluation of a Phosphinate Analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase."
  128. C.-C. Lin, C.-H. Lin, C.-H. Wong  (1997)  Tetrahedron Letters  38, 2649-2652  "Sialic Acid Aldolase-Catalyzed Condensation of Pyruvate and N-Substituted Mannosamine: A Useful Method for the synthesis of N-substituted sialic acids."
  129. S. Chen, C.-H. Lin, D. S. Kwon, C. T. Walsh, J. S. Coward  (1997)  JOURNAL OF MEDICINAL CHEMISTRY  40(23), 3842-3850  "Synthesis and Biological Evaluation of Phosphonates, and Phosphonamidates as Potent Inhibitor of Glutathionylspermidine Synthetase."
  130. C. H. Lin, B. W. Murray, I. R. Ollmann and C. H. Wong  (1997)  Biochemistry  36, 780-785  "Why is CMP-ketodeoxyoctonate highly unstable?"
  131. I.-S. Park, C.-H. Lin, C. T. Walsh  (1996)  Biochemistry  35, 10464-10471  "Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B."
  132. T. Sugai, C.-H. Lin, G.-J. Shen, C.-H. Wong  (1995)  BIOORGANIC & MEDICINAL CHEMISTRY  3, 313-320  "CMP-KDO Synthetase: Overproduction and Application to the Synthesis of CMP-KDO and Analogs"
  133. C. H. Lin and G. J. Shen  (1995)  J. Am. Chem. Soc  117, 8031-8032  "Enzymatic synthesis and regeneration of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) for regioselective sulfation of oligosaccharides"
  134. C.-H. Lin, M. Shimazaki, C.-H. Wong, M. Koketsu, L. R. Juneja, M. Kim  (1995)  BIOORGANIC & MEDICINAL CHEMISTRY  3, 1625-1630  "Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin"
  135. J.-M. Fang, C.-H. Lin, C. W. Bradshaw, C.-H. Wong  (1995)  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS  1, 967 - 978  "Enzyme in Organic Synthesis: Oxidoreductions"
  136. C.-H. Wong, Y. Ichikawa, T. Kajimoto, K. K.-C. Liu, G.-J. Shen, C.-H. Lin, Y.-F. Wong, D. P. Dumas, Y.-C. Lin,   (1993)  Pure and Applied Chemistry  65, 803-808  "Practical Synthesis of Carbohydrates Based on Aldolases and Glycosyl Transferases"
  137. C. H. Lin  (1992)  J Am Chem Soc  114, 10138-10145  "Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: Synthesis of both enantiomers of high carbon monosaccharides"

Please visit the website (http://idv.sinica.edu.tw/chunhung) for the details. Research in Lin’s lab involves multi-disciplinary areas including glycobiology, enzymology, synthetic chemistry and biophysics. Special emphasis is stressed to develop bioorganic and biochemical approaches for investigating the carbohydrate-related enzymes at molecular level, particularly in association with infectious diseases and cancers. Development of enzyme inhibitors has been carried out to study how small molecules interact with proteins and in turns, understand how potent enzyme inhibitors intervene in pathogenesis. Great success has been made to establish practical activity assays with high sensitivity and throughput, paving the way for discovery of the most potent glycosidase inhibitor to date (Ki = 0.46 pM).

Positions Held
  • 2007 – present   Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 2017 – 2020   Director, Department of Academic Affairs and Instrument Service, Academia Sinica
  • 2014   Outstanding Research Award, Ministry of Science and Technology
  • 2014 – 2017   Deputy Director, Institute of Biological Chemistry, Academia Sinica
  • 2011   Investigator Award of Academia Sinica, Academia Sinica
  • 2010   Young Investigator Award, Academia Sinica
  • 2010   Young Scholar Award, Tien-De Li Biomedical Foundation
  • 2008   The Top Ten Rising Stars in Taiwan, Selected by the Central NEws Agency of Taiwan
  • 2006   Excellent Young Scholar Award, The Chemical Society Located at Taipei
  • 2005   Mentor Recognition Award, University of California, San Diego
  • 2002 – 2004   Secretary-General, Taiwan Biophysics Society
  • 2002 – 2007   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1998   Heritage Prize and Fellowship, Li’s Foundation
  • 1998 – 2002   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1993 – 1994   Glaxo Fellowship, Scripps Research Institute
Degrees
  • 1995 – 1997   Research Fellow, Harvard Medical School
  • 1990 – 1995   Ph.D., Chemistry, Scripps Research Institute.
  • 1986 – 1990   B.S., Chemistry, National Taiwan University.
Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium.
Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KT*, Lin CH*
Commun Biol. (2020)
Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes.
Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, Lin CH*
J Med Chem. (2020)
Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence.
Jan HM, Chen YC, Shih YY, Huang YC, Tu Z, Ingle AB, Liu SW, Wu MS, Gervay-Hague J, Mong KKT, Chen YR, Lin CH
Chemical Science (2016)
Development of fucosyltransferase and fucosidase inhibitors.
Tu Z, Lin YN, Lin CH
Chemical Society Reviews (2013)
In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method.
Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, Lin CH
Angew Chem Int Ed. (2012)
Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range.
H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin, A.H.-J.Wang
Angew Chem Int Ed. (2010)
Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells.
Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin
Proc. Natl. Acad. Sci. USA (2009)
Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design.
H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin
J Biol Chem (2007)
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase.
C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin
EMBO J (2006)
Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.
C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin
Angew Chem Int Ed. (2003)
  1. Lai ZS, Yeh TK, Chou YC, Hsu T, Lu CT, Kung FC, Hsieh MY, (Lin CH), Chen CT, James Shen CK, Jiaang WT  (2021-01)  Eur J Med Chem.  209, 112938  "Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease."
  2. Verma N, Tu Z, Lu MS, Liu SH, Renata S, Phang R, Liu PK, Ghosh B, (Lin CH)*  (2021-01)  The Journal of Organic Chemistry  86(1), 892-916  "Threshold of Thioglycoside Reactivity Difference Is Critical for Efficient Synthesis of Type I Oligosaccharides by Chemoselective Glycosylation."
  3. Abdu-Allah HHM, Wu SC, (Lin CH), Tseng YY  (2020-12)  European Journal of Medicinal Chemistry  208, 112707  "Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands"
  4. Chen YR, Naresh A, Liang SY, (Lin CH), Chein RJ, Lin HC  (2020-08)  Angewandte Chemie-International Edition  59(32), 13537-13541  "Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis."
  5. Dashnyam P, Lin HY, Chen CY, Gao S, Yeh LF, Hsieh WC, Tu Z, (Lin CH)*  (2020-05)  Journal of medicinal chemistry  63(9), 4617-4627  "Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes."
  6. Jan HM, Chen YC, Yang TC, Ong LL, Chang CC, Muthusamy S, Abera AB, Wu MS, Gervay-Hague J, Mong KT*, (Lin CH)*  (2020-03)  Communications Biology  3(1), 120  "Cholesteryl alpha-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium."
  7. Hong MH, Lin WH, Weng IC, Hung YH, Chen HL, Chen HY, Chen P, (Lin CH), Yang WY, Liu FT  (2020-01)  Glycobiology  30(1), 36-48  "Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition."
  8. Siew JJ, Chen HM, Chen HY, Chen HL, Chen CM, Soong BW, Wu YR, Chang CP, Chan YC, (Lin CH), Liu FT, Chern Y  (2019-08)  Nature communications  10(1), 3473  "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease."
  9. Hsieh FJ, Sotoma S, Lin HH, Cheng CY, Yu TY, Hsieh CL, (Lin CH), Chang HC  (2019-06)  ACS applied materials & interfaces  11(22), 19774-19781  "Bioorthogonal Fluorescent Nanodiamonds for Continuous Long-Term Imaging and Tracking of Membrane Proteins."
  10. Hsieh FJ, Chen YW, Hui YY, (Lin CH), Chang HC  (2019-05)  Micromachines  10(5), 304  "Quantification and Imaging of Antigens on Cell Surface with Lipid-Encapsulated Fluorescent Nanodiamonds."
  11. Li FY, Weng IC, (Lin CH), Kao MC, Wu MS, Chen HY, Liu FT  (2019-02)  Glycobiology  29(2), 151-162  "Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner."
  12. Chuaboon L, Wongnate T, Punthong P, Kiattisewee C, Lawan N, Hsu CY, (Lin CH), Bornscheuer U, Chaiyen P  (2019-02)  Angewandte Chemie - International Edition  58(8), 2428-2432  "One-Pot Bioconversion of L-Arabinose to L-Ribulose in an Enzymatic Cascade."
  13. Lu YC, Mondal S, Wang CC, (Lin CH), Mong KT  (2019-01)  Chembiochem  20(2), 287-294  "Diverse Synthesis of Natural Trehalosamines and Synthetic 1,1'-Disaccharide Aminoglycosides."
  14. Vinals DF, Kitov PI, Tu Z, Zou C, Cairo CW, (Lin CH), Derda R*  (2019-01)  Peptide Science  111(1), e24097  "Selection of galectin‐3 ligands derived from genetically encoded glycopeptide libraries."
  15. Dashnyam P, Mudududdla R, Hsieh TJ, Lin TC, Lin HY, Chen PY, Hsu CY, (Lin CH)  (2018-11)  Scientific reports  8(1), 16372  "beta-Glucuronidases of opportunistic bacteria are the major contributors to xenobiotic-induced toxicity in the gut."
  16. Yang CY, Chiang HC, Kuo CJ, Hsu CW, Chan SF, Lin ZY, (Lin CH), Chen YT  (2018-04)  ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY  7(7), Q3153-Q3158  "Hepatocellular Carcinoma Diagnosis by Detecting alpha-Fucosidase with a Silicon Nanowire Field-Effect Transistor Biosensor."
  17. Hsieh FJ, Chen YW, Huang YK, Lee HM, (Lin CH), Chang HC  (2018-02)  Analytical chemistry  90(3), 1566-1571  "Correlative Light-Electron Microscopy of Lipid-Encapsulated Fluorescent Nanodiamonds for Nanometric Localization of Cell Surface Antigens."
  18. Chang LL, Hsu WH, Kao MC, Chou CC, Lin CC, Liu CJ, Weng BC, Kuo FC, Kuo CH, Lin MH, Wang CJ, (Lin CH), Wu DC, Huang SK  (2018-02)  Scientific reports  8(1), 3821  "Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases."
  19. Chan YC, Lin HY, Tu Z, Kuo YH, Hsu SD, (Lin CH)  (2018-01)  International journal of molecular sciences  19(2), 392  "Dissecting the Structure-Activity Relationship of Galectin-Ligand Interactions."
  20. Bella M, Yan S, Šesták S, Kozmon S, (Lin CH), Mucha J, Koóš M  (2017-11)  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY  2017(41), 6179–6191  "Synthesis of a β-d-Psicofuranosyl Sulfone and Inhibitory-Activity Evaluation Against N-Acetylglucosaminyltransferase I."
  21. Chien CTH, Ho MR, (Lin CH), Hsu STD*  (2017-08)  MOLECULES  22(8), 1357  "Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange."
  22. Hu JC, Feng AW, Chang BY, (Lin CH), Mong KT  (2017-06)  Organic & biomolecular chemistry  15(25), 5345-5356  "A flexible 1,2-cis alpha-glycosylation strategy based on in situ adduct transformation."
  23. Wu SY, Huang JH, Chen WY, Chan YC, (Lin CH), Chen YC, Liu FT, Wu-Hsieh BA  (2017-02)  Frontiers in immunology  8, 48  "Cell Intrinsic Galectin-3 Attenuates Neutrophil ROS-Dependent Killing of Candida by Modulating CR3 Downstream Syk Activation."
  24. Wu JL, Wu HY, Tsai DY, Chiang MF, Chen YJ, Gao S, Lin CC, (Lin CH), Khoo KH, Chen YJ, Lin KI  (2016-08)  Nature communications  7, 12526  "Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells."
  25. Hsieh TJ, Lin HY, Tu Z, Lin TC, Wu SC, Tseng YY, Liu FT, Hsu ST, (Lin CH)  (2016-07)  Scientific reports  6, 29457  "Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors."
  26. Chen YB, Liu SH, Hsieh MT, Chang CS, (Lin CH), Chen CY, Chen PY, Lin HC  (2016-04)  The Journal of organic chemistry  81(7), 3007-3016  "Stereoselective Synthesis of Spiro Bis-C,C-alpha-arylglycosides by Tandem Heck Type C-Glycosylation and Friedel-Crafts Cyclization."
  27. Jan HM, Chen YC, Shih YY, Huang YC, Tu Z, Ingle AB, Liu SW, Wu MS, Gervay-Hague J, Mong KKT, Chen YR, (Lin CH)  (2016)  Chemical Science  7(9), 6208-6216  "Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how the uptake of human lipids enhances bacterial virulence"
  28. Tony Mong KK, Shiau KS, Lin YH, Cheng KC, (Lin CH)  (2015-12)  Organic & biomolecular chemistry  13(47), 11550-11560  "A concise synthesis of single components of partially sulfated oligomannans."
  29. Liu CH, Chien CT, (Lin CH), Hsu ST  (2015-10)  Biomolecular NMR assignments  9(2), 427-430  "NMR assignments of the C-terminal domain of human galectin-8."
  30. Bella M, Koos M, (Lin CH)  (2015-09)  Beilstein journal of organic chemistry  11, 1547-1552  "Towards inhibitors of glycosyltransferases: A novel approach to the synthesis of 3-acetamido-3-deoxy-D-psicofuranose derivatives."
  31. Hsu YL, Nandakumar M, Lai HY, Chou TC, Chu CY, (Lin CH), Lo LC  (2015-08)  The Journal of organic chemistry  80(16), 8458-8463  "Development of Activity-Based Probes for Imaging Human alpha-l-Fucosidases in Cells."
  32. Nandakumar M, Hsu YL, Lin JC, Lo C, Lo LC, (Lin CH)  (2015-07)  Chembiochem : a European journal of chemical biology  16(11), 1555-1559  "Detection of Human alpha-L-Fucosidases by a Quinone Methide-Generating Probe: Enhanced Activities in Response to Helicobacter pylori Infection."
  33. Cheng CW, Chou CC, Hsieh HW, Tu Z, (Lin CH), Nycholat C, Fukuda M, Khoo KH  (2015-06)  Analytical chemistry  87(12), 6380-6388  "Efficient Mapping of Sulfated Glycotopes by Negative Ion Mode nanoLC-MS/MS-Based Sulfoglycomic Analysis of Permethylated Glycans."
  34. Hsieh TJ, Lin HY, Tu Z, Huang BS, Wu SC, (Lin CH)*  (2015-05)  PLoS One  10(5), e0125946  "Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc"
  35. Tu Z, Liu PK, Wu MC, (Lin CH)*  (2015-04)  Israel Journal of Chemistry  55(3-4), 325-335  "Expeditious synthesis of orthogonally protected oligosaccharides through consecutive protection and glycosylation steps"
  36. Baráth M, (Lin CH), Tvarošk I, Hirsch J  (2015-02)  CHEMICAL PAPERS  69(2), 348-357  "Development of transition state analogue inhibitors for N-acetylglycosyltransferases bearing D-psicoor D-tagatofuranose scaffolds"
  37. Chou CC, Chiang BY, Lin JC, Pan KT, (Lin CH), Khoo KH*  (2015-01)  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY  26(1), 120-132  "Characteristic tandem mass spectral features under various collision chemistries for site-specific identification of protein S-glutathionylation"
  38. Lin JC, Chiang BY, Chou CC, Chen TC, Chen YJ, Chen YJ, (Lin CH)  (2015-01)  Molecules  20(1), 1452-1474  "Glutathionylspermidine in the Modification of Protein SH Groups: The Enzymology and Its Application to Study Protein Glutathionylation"
  39. Chen YB, Wang SI, Lin ZP, (Lin CH), Hsieh MT, Lin HC  (2015)  Tetrahedron  71, 350-358  "Stereoselective glycosylation of d-galactals by diethyl phosphorochloridite- and AlCl3-assisted Ferrier rearrangement"
  40. C.-W. Lin, K.-W. Hon, B. Ghosh, P.-H. Li, H.-Y. Lin, P.-H. Chan, Y.-C. Chen, (C.-H. Lin), K.-K. T. Mong*  (2014-09)  Chemistry-An Asian Journal  9(7), 1786-1796  "Synthesis of Oligomeric Mannosides and Their Structure-Binding Relationship with Concanavalin A"
  41. Lin JC, Chou CC, Tu Z, Yeh LF, Wu SC, Khoo KH, (Lin CH)  (2014-08)  Journal of proteome research  13(8), 3523-3529  "Characterization of Protein Serotonylation via Bioorthogonal Labeling and Enrichment."
  42. Ghosh B, Lai YH, Shih YY, Pradhan TK, (Lin CH), Mong KK.  (2013-12)  Chemistry-An Asian Journal  8(12), 3191-3199  "Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties"
  43. Liao SF, Liang CH, Ho MY, Hsu TL, Tsai TI, Hsieh YS, Tsai CM, Li ST, Cheng YY, Tsao SM, Lin TY, Lin ZY, Yang WB, Ren CT, Lin KI, Khoo KH, (Lin CH), Hsu HY, Wu CY, Wong CH.  (2013-08)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  110(34), 13809-13814  "Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes."
  44. Huang HW, Chen CH, (Lin CH), Wong CH, Lin KI.  (2013-07)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  110(27), 10928-10933  "B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention"
  45. Z. Tu, H.-W. Hsieh, C.-M. Tsai, C.-W. Hsu, S.-G. Wang, K.-J. Wu, K.-I. Lin*, (C.-H. Lin)*  (2013-07)  Chemistry-An Asian Journal  8(7), 1536-1550  "Synthesis and characterization of sulfated Gal-β-1, 3/1,4 -GlcNAc disaccharides through consecutive protection /glycosylation steps"
  46. Lin JC, Chou CC, Gao S, Wu SC, Khoo KH, (Lin CH)  (2013-05)  Chembiochem : a European journal of chemical biology  14(7), 813-817  "An in Vivo Tagging Method Reveals that Ras Undergoes Sustained Activation upon Transglutaminase-Mediated Protein Serotonylation."
  47. Tu Z, Lin YN, (Lin CH)  (2013-05)  Chemical Society reviews  42(10), 4459-4475  "Development of fucosyltransferase and fucosidase inhibitors."
  48. J.-T. Wang, T.-C. Lin, Y.-H. Chen, (C.-H. Lin)* and J.-M. Fang*  (2013-05)  MedChemComm  4(5), 783-791  "Polyhydroxylated pyrrolidine and 2-oxapyrrolizidine as glycosidase inhibitors"
  49. Sue-Ming Chang, Zhijay Tu, Hau-Ming Jan, Jia-Fu Pan and (Chun-Hung Lin)*  (2013-05)  CHEMICAL COMMUNICATIONS  49(39), 4265-4267  "Rapid synthesis of oligomannosides with orthogonally protected monosaccharides"
  50. Z.-P. Lin, F.-F. Wong, Y.-B. Chen, (C.-H. Lin), M.-T. Hsieh, J.-C. Lien, Y.-H. Chou, H.-C. Lin   (2013-05)  Tetrahedron  69(19), 3991-3999  "Regioselective and reductive cleavage of allyl ethers by NaBH4–HOAc"
  51. Z.-P. Lin, F.-F. Wong, Y.-B. Chen, Y.-C. Lin, M. Kimura, K. Kaneko, H. Takayama, J.-B. Wu, (C.-H. Lin),* H.-C. Lin,*  (2013-03)  Tetrahedron  69(11), 2494-2500  "Synthesis of α-2-deoxy-ulosides by Michael addition of hex-1-en-3-ones"
  52. Davis RA, (Lin CH), Gervay-Hague J  (2012-09)  Chemical communications  48(72), 9083-9085  "Chemoenzymatic synthesis of cholesteryl-6-O-tetradecanoyl-alpha-D-glucopyranoside: a product of host cholesterol efflux promoted by Helicobacter pylori."
  53. Yu-Nong Lin, Daniel Stein, Sheng-Wei Lin, Sue-Ming Chang, Ting-Chien Lin, Yu-Ruei Chuang, Jacquelyn Gervay-Hague, Hisashi Narimatsu, (Chun-Hung Lin)*  (2012-06)  ADVANCED SYNTHESIS & CATALYSIS  354(9), 1750-1758  "Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors"
  54. Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, (Lin CH)  (2012-06)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  51(24), 5871-5875  "In Vivo tagging and characterization of s-glutathionylated proteins by a chemoenzymatic method."
  55. Y.-F. Wang, W.-I. Liao, Y.-D. Kuo, S.-Y. Guu, H.-C. Wang, (C.-H. Lin), I.-J. Su, C.-F. Chang  (2012-06)  Future Virology  7(6), 621-633  "Receptor binding surveillance of influenza clinical isolates"
  56. Yang PY, Chen WX, Chang FY, Chen HW, (Lin CH), Hsu YC, Wu JH  (2012-02)  Apoptosis : an international journal on programmed cell death  17(2), 154-163  "HepG2 cells infected with Klebsiella pneumoniae show DNA laddering at apoptotic and necrotic stages."
  57. C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, (C.-H. Lin)*  (2011-10)  ChemBioChem  12(15), 2306-2309  "An Acyloxymethyl Ketone-based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli"
  58. C.-M. Tsai, C.-H. Guan, H.-W. Hsieh, T.-L. Hsu, K.-J. Wu, Z.-J. Tu, (C.-H. Lin)*, K.-I. Lin*  (2011-08)  J Immunol  187(4), 1643-1652  "Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation"
  59. C.-M. Chau, K.-J Liu, (C.-H. Lin)  (2011-07)  BIORESOURCE TECHNOLOGY  102(21), 10136-10138  "Enzymatic synthesis of sialic acid derivatives by immobilized lipase from Candida antarctica"
  60. C.-F. Chang, J.-F. Pan, C.-N. Lin, I.-L. Wu, C.-H. Wong, (C.-H. Lin)*  (2011-07)  Glycobiology  21(7), 895-902  "Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers."
  61. H.-C. Lin, J.-F. Pan, Y.-B. Chen, Z.-P. Lin, (C.-H. Lin)*  (2011-06)  Tetrahedron  67(34), 6362-6368  "Stereoselective glycosylation of endo-glycals by microwave- and AlCl3-assisted catalysis"
  62. Y.-Y. Chen, T.-P. Ko, (C.-H. Lin), W.-H. Chen, A. H.-J. Wang*  (2011-04)  J Struct Biol  175(3), 300-310  "Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance"
  63. C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, (C.-H. Lin), C.-H. Wong, A. H.-J. Wang*  (2011-04)  J Biol Chem  286(16), 14057-14064  "Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251."
  64. W.-I. Liao, Y.-F. Wang, Y.-D. Kuo, Y.-D., (C.-H. Lin), T.-C. Chang I.-J. Su, J.-R. Wang, C.-F. Chang*  (2011-03)  Future Med Chem  3(3), 283-296  "Profiling of influenza viruses by high-throughput carbohydrate membrane array"
  65. P.-H. Pai, H.-J. Wu, (C.-H. Lin)*, A. H.-J. Wang*  (2011-03)  PROTEIN SCIENCE  20(3), 557-566  "Structure and mechanism of E. coli glutathionylspermidine amidase belonging to the family of cysteine, histidine-dependent amidohydrolase/peptodase"
  66. P.-C. Pan, H.-W. Chen, P.-K. Wu, Y.-Y. Wu, (C.-H. Lin), J.-H. Wu*  (2011-02)  Exp Biol Med  236(2), 219-226  "Mutation in fucose synthesis gene of Klebsiella pneumonia affects capsule composition and virulence in mice"
  67. Shih TL, Liang MT, Wu KD, (Lin CH)  (2011)  Carbohydrate Research  346(2), 183-190  "Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors."
  68. Lammerts van Bueren A, Popat SD, (Lin CH), Davies GJ  (2010-09)  CHEMBIOCHEM  11(14), 1971-1974  "Structural and thermodynamic analyses of alpha-L-fucosidase inhibitors."
  69. Chiang BY, Chen TC, Pai CH, Chou CC, Chen HH, Ko TP, Hsu WH, Chang CY, Wu WF, Wang AH, (Lin CH)  (2010-08)  JOURNAL OF BIOLOGICAL CHEMISTRY  285(33), 25345-25353  "Protein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATION."
  70. Hui-Chang Lin, Yen-Bo Chen, Zi-Ping Lin, Fung Fuh Wong, (Chun-Hung Lin) and Shao-Kai Lin  (2010-07)  Tetrahedron  66(27-28), 5229-5234  "Synthesis of 1,7-dioxaspiro[5.5]undecanes and 1-oxa-7-thiaspiro[5.5]undecanes from exo-glycal"
  71. Ho CW, Popat SD, Liu TW, Tsai KC, Ho MJ, Chen WH, Yang AS, (Lin CH).  (2010-05)  ACS Chem. Biol.  5(5), 489-497  "Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-β-Hexosaminidase Inhibitors"
  72. Ying-Yin Chen, Tzu-Ping Ko, Wei-Hung Chen, Li-Ping Lo, (Chun-Hung Lin), Andrew H.-J. Wang  (2010-01)  Journal of Structural Biology  169(1), 25-35  "Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism"
  73. H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, (C.-H Lin), A.H.-J.Wang  (2010-01)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  49(2), 337-340  "Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range"
  74. Hui-Chang Lin, Hsu-Hsuan Wu, Zi-Ping Lin, Chih-Yuan Lin, (Chun-Hung Lin), Kun-Lung Chen, Fung Fuh Wong  (2009-12)  Tetrahedron Letters  50(52), 7327-7329  "Microwave-assisted stereoselective α-2-deoxyglycosylation of hex-1-en-3-uloses"
  75. Ta-Wei Liu, Ching-Wen Ho, Hsin-Hung Huang, Sue-Ming Chang, Shide D. Popat, Yi-Ting Wang, Ming-Shiang Wu, Yu-Ju Chen, Chun-Hung Lin  (2009-08)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  106(34), 14581-14586  "Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells"
  76. S.-W. Liu, C.-S. Chen, S.-S. Chang, K.-K. Mong, (C.-H. Lin), C.-W. Chang, C.-Y. Tang, Y.-K. Li  (2009-01)  Biochemistry  48(1), 110-120  "Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism. "
  77. C.-S. Shi, G-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu   (2008-11)  Blood  112(9), 3661-3670.  "Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccahride-induced inflammatory response"
  78. D. B. Stein, Yu Nong. Lin, Chun Hung Lin*  (2008-10)  Adv. Synth. Catal.  350(14-15), 2313-2321  "Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens"
  79. Hsu HJ, Tsai KC, Sun YK, Chang HJ, Huang YJ, Yu HM, (Lin CH), Mao SS, Yang AS  (2008-05)  The Journal of biological chemistry  283(18), 12343-12353  "Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling."
  80. Chiou-Yueh Yeh, Chun-Nan Lin, Chuan-Fa Chang, Chun-Hung Lin, Huei-Ting Lien, Jen-Yang Chen, and Jean-San Chia  (2008)  Infection and Immunity  76(3), 1170-1178  "C-Terminal Repeats of Clostridium difficile Toxin A Induce Production of Chemokine and Adhesion Molecules in Endothelial Cells and Promote Migration of Leukocytes"
  81. Y. M. Shao, W. B. Yang, T. H. Kuo, K. C. Tsai, C. H. Lin, A. S. Yang, P. H. Liang and C. H. Wong  (2008)  Bioorganic & medicinal chemistry  16(8), 4652-4660  "Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease"
  82. T. L. Shih, R. Y. Yang, S. T. Li, C. F. Chiang and C. H. Lin  (2007)  J Org Chem  72(11), 4258-4261  "Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from D-(-)-Quinic Acid as Potent Glycosidase Inhibitors"
  83. H. Y. Sun, T. P. Ko, S. W. Lin, J. L. Liu, A. H. J. Wang and C. H. Lin  (2007)  J Biol Chem  282(13), 9973-9982  "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design"
  84. Y. M. Shao, W. B. Yang, H. P. Peng, M. F. Hsu, K. C. Tsai, T. H. Kuo, A. H. Wang, P. H. Liang, C. H. Lin, A. S. Yang and C. H. Wong  (2007)  Chembiochem  8(14), 1654-1657  "Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors"
  85. J. Yin, A. Hashimoto, M. Izawa, K. Miyazaki, G.Y Chen, H. Takematsu, Y. Kozutsumi, A. Suzuki, K. Furuhata, FL Cheng, CH Lin, C. Sato, K. Kitajima and R. Kannagi  (2006-03)  Cancer Res  66(6), 2937-2945  "Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells"
  86. S. W. Lin, J. R. Li, T. M. Yuan and C. H. Lin  (2006)  Biochemistry  45(26), 8108-8116  "Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability."
  87. S. C. Chen, Y. C. Chang, C. H. Lin, C. H. Lin and S. H. Liaw  (2006)  J. Biol. Chem  281, 7605-7613  "Crystal Structure of a Bifunctional Deaminase and Reductase from Bacillus Substilus Involved in Riboflavin Biosynthsis"
  88. C. W. Ho, C. F. Chang, Y. N. Lin, H. T. Lee, Y. T. Wu, C. Y. Wu, S. W. Liu, Y. K. Li, C. H. Lin  (2006)  Biochemistry  45, 5695-5702  "Discovery of Different Types of Inhibition between the Human and Thermotoga maritime alpha-Fucosidases by Fuconojirimycin-based Derivatives."
  89. C. H. Pai, B. Y. Chiang, T. P. Ko, C. C Chou, C. M. Chong, F. J. Yen, S. Chen, J. K. Coward, A. H. J. Wang and C.-H. Lin  (2006)  EMBO J  25(24), 5970-5982  "Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase."
  90. C. H. Chien, C. H. Tsai, C. H. Lin, C. Y. Chou and X. Chen  (2006)  Biochemistry  45, 7006-7012  "Identification of hydrophobic residues critical for DPP-IV dimerization"
  91. S. J. Hsu, H. C. Lin and C. H. Lin  (2006)  Carbohydrate Research  341, 1428-1437  "Inter- and Intramolecular Glycosylation of exo-Glycals Promoted by Metallic Lewis Acid"
  92. H. J. Lee, Y. S. Chen, C. Y. Chou, CH. Chien, C. H. Lin, G. G. Chang and X. Chen  (2006)  J. Biol. Chem  281, 38653-38662  "Investigation of the dimer interface and substrate specificity of prolyl dipeptiase DPP8"
  93. C. K. Chang, S. C. Sue, T. H. Yu, C. M. Hsieh, C. K. Tsai, Y.C. Chiang, S. J Lee, H.H. Hsiao, W. J. Wu, W. L. Chang, C. H. Lin , T. H. Huang  (2006)  J. Biomed. Sci  13, 59-72  "Modular Organization of SARS Coronavirus Nucleocapsid Protein"
  94. Y. S. E. Cheng, K. H. Lo, H. H. Hsu, Y.M. Shao, W. B.Yang, C. H. Lin, C. H. Wong  (2006)  J. Virol. Methods  137, 82-87  "Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in E. coli"
  95. H. C. Lin, W. P. Du, C. C. Chang and C. H. Lin  (2005)  Tetrahedron Letters  46, 5071-5076  "Different Reaction Routes Found in Acid-Catalyzed Glycosylation of endo- and exo-Glycals: Competition between Ferrier Rearrangement and Protonation"
  96. J. J. Shie, J. M. Fang, C. J. Kuo, T. H. Kuo, P. H. Liang, H. J. Huang, W.-B. Yang, C. H. Lin, J. L. Chen, Y. T. Wu and C. H. Wong  (2005)  J. Med. Chem  48, 4469-4473  "Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease"
  97. C. H. Lin, H. C. Lin and W. B. Yang  (2005)  Current Topics in Medicinal Chemistry  5, 1431-1457  "exo-Glycal chemistry: general aspects and synthetic applications for biochemical use."
  98. H. C. Lin, C. C. Chang, J. Y. Chen and C. H. Lin  (2005)  Tetrahedron: Asymmetry  16, 297-301  "Stereoselective glycosylation of exo-glycals by microwave-assisted Ferrier rearrangement"
  99. H.H. Huang, H.K. Liao, Y.J. Chen, T.S. Hwang, YiHan Lin, C.H. Lin  (2005)  Journal of the American Society for Mass Spectrometry  16, 324-332  "Structural Characterization of Sialic Acid Synthase by Electrospray Mass Spectrometry: A Tetrameric Enzyme Composed of Dimeric Dimers"
  100. G. T. Fan, Y. S. Pan, K. C. Lu, Y. P. Cheng, C. H. Wong, W. C. Lin, C. H. Lin, J. M. Fang and C. C. Lin  (2005)  Tetrahedron  61, 1855-1862  "Synthesis of a-Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes"
  101. C. F. Teo, T. S. Hwang, P. H. Chen, C. H. Hung, H. S. Gao, L. S. Chang and C. H. Lin  (2005)  Adv. Synth. Catal  347, 967-972  "Synthesis of Sialyl TN Glycopeptides― Enzymatic Sialylation by alpha2,6-Sialyltransferase from Photobacterium damsela"
  102. C. F. Chang, C. W. Ho, C. Y. Wu, C. H. Wong and C. H. Lin  (2004)  Chemistry & Biology  11, 1301-1306  "Discovery of Picomolar Slow Tight-Binding Inhibitors of alpha-Fucosidase"
  103. H. Y. Hsu, K. F. Hua, C. C. Lin, C. H. Lin, J. Hsu and C. H. Wong  (2004)  J. Immunol  173, 5989-5999  "Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling pathways"
  104. M. C. Cheng, C. H. Lin, H. J. Lin, Y. P. Yu and S. H. Wu  (2004)  Glycobiology  14, 147-155  "Hydrolysis, lactonization, and identification of alpha(2 --> 8)/alpha(2 --> 9) alternatively linked tri-, tetra-, and polysialic acids"
  105. H. S. Chen, Y. F. Tsai, S. Lin, K. H. Khoo, C. H. Wong and C. H. Lin  (2004)  Bioorganic & Medicinal Chemistry  12, 5595-5601  "Studies on the Immuno-modulating and Anti-tumor Activities of Ganoderma lucidum (Reishi) Polysaccharides"
  106. C. Y. Wu, C. F. Chang, J. S. Chen, C. H. Wong and C. H. Lin  (2003)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  42, 4661-4664  "Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors"
  107. The Y.-J. Chen, T.-S. Hwang, X.-H. Hwnag, H.-K. Liao, C.-H. Lin  (2003)  The Proceedings of the International Symposium on Biomolecular Chemistry 2003  96-99  "Sialic Acid Synthase from Escherichia coli Structural Characterization by Mass Spectrometry"
  108. H. C. Lin, W. B. Yang, Y. F. Gu, C. Y. Chen, C. Y. Wu and C. H. Lin  (2003)  Org Lett  5, 1087-1089  "Stereoselective glycosylation of exo-glycals accelerated by Ferrier-type rearrangement"
  109. C.-F. Chang, W.-B. Yang, C.-C. Chang, C.-H. Lin  (2002)  Tetrahedron Letters  43, 6515-6519  "Inter- and Intramolecular alcohol additions of exo-Glycals"
  110. W. B. Yang, Y. Y. Yang, Y. F. Gu, S. H. Wang, C. C. Chang and C. H. Lin  (2002)  J Org Chem  67, 3773-3782  "Stereochemistry in the synthesis and reaction of exo-glycals"
  111. T. S. Hwang, C. H. Hung, C. F. Teo, G. T. Chen, L. S. Chang, S. F. Chen, Y. J. Chen and C. H. Lin  (2002)  Biochem Biophys Res Commun  295, 167-173  "Structural characterization of Escherichia coli sialic acid synthase"
  112. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, (Lin CH)  (2002)  Bioorganic & medicinal chemistry  10(4), 1057-1062  "Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities."
  113. W.-B. Yang, Sachindra S. Patil, C.-H. Tsai, C.-H. Lin, J.-M. Fang  (2002)  Tetrahedron Letters  58, 253-259  "The synthesis of l-gulose and l-xylose from d-gluconolactone"
  114. Y. P. Yu, M. C. Cheng, H. R. Lin, C. H. Lin and S. H. Wu  (2001)  J Org Chem  66, 5248-5251  "Acid-catalyzed hydrolysis and lactonization of alpha2,8-linked oligosialic acids"
  115. C. H. Lin, C. C. Lin  (2001)  Adv Exp Med Biol  491, 215-230  "Enzymatic and chemical approaches for the synthesis of sialyl glycoconjugates"
  116. W.-B. Yang, C.-F. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin.  (2001)  Tetrahedron Letters  42, 4567-4660  "Expeditious Synthesis of C-Glycosyl Conjugated Dienes and Aldehydes from Sugar Lactones"
  117. W.-B. Yang, T.-I. Wu, C.-C. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin.  (2001)  Tetrahedron Letters  42, 6907-6910  "Facile Synthesis of Conjugated exo-Glycals "
  118. M. D. Burkart, M. Izumi, E. Chapman, C. H. Lin and C. H. Wong  (2000)  J Org Chem  65, 5565-5574  "Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides"
  119. Y.-Y. Yang, W.-B. Yang, C.-F. Teo, C.-H. Lin  (2000)  Synlett  2000(11), 1634-1636  "Regioselective Deprotection of tert-Butyldimethylsilyl Ethers by Boron Trichloride"
  120. M. C. Cheng, C. H. Lin, H. Y. Wang, H. R. Lin and S. H. Wu  (2000)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  39, 772-776  "Regioselective Lactonization of Tetrasialic Acid"
  121. W. B. Yang  (2000)  Tetrahedron Lett  41, 2569-2572  "The expeditious preparation and reactivity of some protected forms of gluconolactone."
  122. M. C. Cheng, C. H. Lin, K. H. Khoo and S. H. Wu  (1999)  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  38, 686-689  "Regioselective Lactonization of α-(2,8)-Trisialic Acid"
  123. C. H. Lin, S. Chen, D. S. Kwon, J. K. Coward and C. T. Walsh  (1997)  Chem Biol  4, 859-866  "Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase"
  124. I.-S. Park, C.-H. Lin, C. T. Walsh  (1997)  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  94, 10040-10044  "Bacterial Resistance to Vancomycin: Overproduction, Purification, and Characterizationof VanC2 from Enterococcus casseliflavus as a d-Ala-d-Ser ligase."
  125. D. S. Kwon, C.-H. Lin, S. Chen, J. K. Coward, C. T. Walsh, J. M. Borlinger, Jr.  (1997)  J. Biol. Chem.  272, 2429-2436  "Dissection of Glutathionylspermidine Synthetase/Amidase from Escherichia coli into Autonomously Folding and Functional Synthetase and Amidase Domains."
  126. C. H. Lin, D. S. Kwon, J. M. Bollinger, Jr. and C. T. Walsh  (1997)  Biochemistry  36, 14930-14938  "Evidence for a glutathionyl-enzyme intermediate in the amidase activity of the bifunctional glutathionylspermidine synthetase/amidase from Escherichia coli"
  127. S. Chen, C.-H. Lin, C. T. Walsh, J.K. Coward  (1997)  Bioorg. Med. Chem. Lett.  7, 505-510  "Novel Inhibitors of Trypanothione Biosynthesis: Synthesis and Evaluation of a Phosphinate Analog of glutathionyl spermidine (GSP), a potent, slow-binding inhibitor of GSP synthetase."
  128. C.-C. Lin, C.-H. Lin, C.-H. Wong  (1997)  Tetrahedron Letters  38, 2649-2652  "Sialic Acid Aldolase-Catalyzed Condensation of Pyruvate and N-Substituted Mannosamine: A Useful Method for the synthesis of N-substituted sialic acids."
  129. S. Chen, C.-H. Lin, D. S. Kwon, C. T. Walsh, J. S. Coward  (1997)  JOURNAL OF MEDICINAL CHEMISTRY  40(23), 3842-3850  "Synthesis and Biological Evaluation of Phosphonates, and Phosphonamidates as Potent Inhibitor of Glutathionylspermidine Synthetase."
  130. C. H. Lin, B. W. Murray, I. R. Ollmann and C. H. Wong  (1997)  Biochemistry  36, 780-785  "Why is CMP-ketodeoxyoctonate highly unstable?"
  131. I.-S. Park, C.-H. Lin, C. T. Walsh  (1996)  Biochemistry  35, 10464-10471  "Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B."
  132. T. Sugai, C.-H. Lin, G.-J. Shen, C.-H. Wong  (1995)  BIOORGANIC & MEDICINAL CHEMISTRY  3, 313-320  "CMP-KDO Synthetase: Overproduction and Application to the Synthesis of CMP-KDO and Analogs"
  133. C. H. Lin and G. J. Shen  (1995)  J. Am. Chem. Soc  117, 8031-8032  "Enzymatic synthesis and regeneration of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) for regioselective sulfation of oligosaccharides"
  134. C.-H. Lin, M. Shimazaki, C.-H. Wong, M. Koketsu, L. R. Juneja, M. Kim  (1995)  BIOORGANIC & MEDICINAL CHEMISTRY  3, 1625-1630  "Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin"
  135. J.-M. Fang, C.-H. Lin, C. W. Bradshaw, C.-H. Wong  (1995)  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS  1, 967 - 978  "Enzyme in Organic Synthesis: Oxidoreductions"
  136. C.-H. Wong, Y. Ichikawa, T. Kajimoto, K. K.-C. Liu, G.-J. Shen, C.-H. Lin, Y.-F. Wong, D. P. Dumas, Y.-C. Lin,   (1993)  Pure and Applied Chemistry  65, 803-808  "Practical Synthesis of Carbohydrates Based on Aldolases and Glycosyl Transferases"
  137. C. H. Lin  (1992)  J Am Chem Soc  114, 10138-10145  "Unusual stereoselectivity in sialic acid aldolase-catalyzed aldol condensations: Synthesis of both enantiomers of high carbon monosaccharides"