Research

The tristetraprolin (TTP) family, which regulates mRNA decay, comprises three members in humans and four in rodents. The three related proteins are TTP (also named ZFP36, TIS11), ZFP36L1 (TIS11B, BRF1), and ZFP36L2 (TIS11D, BRF2). We have demonstrated that they play functions in macrophage activation and adipogenesis through destabilization of target mRNAs. Zfp36l3 is a rodent-specific gene, only expressed in the placenta and extraembryonic tissues of mice. All TTP family members have a highly conserved (70% identity) tandem zinc finger (TZF) domain, which is responsible for high-affinity binding to AU-rich elements (AREs) of mRNAs. In eukaryotes, mRNA decay is initiated by deadenylation and the activation of two major decay pathways from the 3′ to the 5′ end or from the 5′ to the 3′ end. Mammalian mRNA deadenylation involved two consecutive phases mediated by the PAN2-PAN3 and the CCR4-NOT complexes, respectively. Recent work indicates that TTP can recruit the CCR4/CAF1/NOT deadenylase complex through direct interaction with CNOT1, resulting in decay of ARE-containing reporter mRNAs. TTP family members share TTP-like activities and promote the deadenylation and destruction of ARE-containing target sequences. However, what specificity in the recruitment of CCR4 and CAF1 paralogs for the individual TTP family member and what the mechanism for the differential role in mRNA deadenylation of the CCR4 and CAF1 deadenylases is unclear. Moreover, how the protein phosphorylation of TTP family involved in deadenylases association is to be investigated.

Degrees and Positions Held
Positions Held
  • 2002 – present   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1994 – 2002   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1989 – 1994   Research Assistant, Institute of Biological Chemistry, Academia Sinica
Degrees
  • 1990 – 1994   Ph.D., Institute of Biochemical Sciences, National Taiwan University
  • 1987 – 1989   M.S., Institute of Biochemical Sciences, National Taiwan University
  • 1983 – 1987   B.S., Department of Agricultural Chemistry,, National Taiwan University
Selected Publications
Chiang, P.Y., Shen, Y.F., Kao, C.H., Su, Y.L., Lin, N.Y., Hsu, P.H., Tsai, M.D., Wang, S.C., Chang, G.D., Lee, S.C., and Chang, C.J.
PLos One (2013)
Yang, F.C., Tan, B., Chen, W.H., Lin, Y.H., Huang, J.Y., Chang, H.Y., Sun, H.Y., Hsu, P.H., Liou, G.G., Shen, J., Chang, C.J., Han, C.C., Tsai, M.D., and Lee, S.C.
Journal of Biological Chemistry (2013)
Chen, Y.L., Jiang, Y.W., Su, Y.L., Lee, S.C., Chang, M.S., and Chang C.J.
Molecular biology reports (2013)
Lin, N.Y., Lin, T.Y., Yang, W.H., Wang, S.C., Wang, K.T., Su, Y.L., Jiang, Y.W., Chang, G.D., and Chang, C.J.
International journal of biological sciences (2012)
Yeh, P.A., Yang, W.H., Chiang, P.Y., Wang, S.C., Chang, M.S. and Chang, C.J.
International journal of biological sciences (2012)
Hee, S.W., Tsai, S.H., Chang, Y.C., Chang, C.J., Yu, I.S., Lee, P.C., Lee, W.J., Yun-Chia Chang, E. and Chuang, L.M.
Obesity (Silver Spring) (2012)
Su, Y.L., Wang, S.C., Chiang, P.Y., Lin, N.Y., Shen, Y.F., Chang, G.D., and Chang C.J.
PLoS One (2012)
Lin, N.Y., Lin, C.T. and Chang, C.J.
Biochemical and biophysical research communications (2008)
Lin, N.Y., Lin, C.T., Chen, Y.L. and Chang, C.J.
The FEBS journal (2007)
Chen, Y.L., Huang, Y.L., Lin, N.Y., Chen, H.C., Chiu, W.C. and Chang, C.J.
Biochemical and biophysical research communications (2006)
Publications List
  1. Yeh CC, (Chang CJ), Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  2. Yeh CC, (Chang CJ), Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  3. Yeh PA, (Chang CJ)  (2017)  PLOS ONE  12(10), e0186037  "A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization."
  4. Wang HH, Lin CY, Su SH, Chuang CT, Chang YL, Lee TY, Lee SC, (Chang CJ)  (2016)  Cell Death and Disease  7(7), e2298  "Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis."
  5. Wang KT, Wang HH, Wu YY, Su YL, Chiang PY, Lin NY, Wang SC, Chang GD, (Chang CJ)*   (2015-07)  Journal of Inflammation-London  12, 42  " Functional regulation of Zfp36l1 and Zfp36l2 in response to lipopolysaccharide in mouse RAW264.7 macrophages."
  6. Chiang PY, Shen YF, Su YL, Kao CH, Lin NY, Hsu PH, Tsai MD, Wang SC, Chang GD, Lee SC, (Chang CJ)  (2013-04)  PloS one  8(4), e61697  "Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes."
  7. Yu-Ling Chen, Yu-Wun Jiang, Yu-Lun Su, Sheng-Chung Lee, Mau-Sun Chang and (Ching-Jin Chang)*  (2013-04)  MOLECULAR BIOLOGY REPORTS  40(4), 2867-2877  "Transcriptional Regulation of Tristetraprolin by NF-κB Signaling in LPS-stimulated Macrophages"
  8. Yang FC, Tan BC, Chen WH, Lin YH, Huang JY, Chang HY, Sun HY, Hsu PH, Liou GG, Shen J, (Chang CJ), Han CC, Tsai MD, Lee SC  (2013)  The Journal of biological chemistry  288(9), 6227-6237  "Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy."
  9. Hu CK, Lee YJ, Colitz CM, (Chang CJ), Lin CT*  (2012-09)  VETERINARY OPHTHALMOLOGY  15(s2), 65-71  "The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats"
  10. Hee SW, Tsai SH, Chang YC, (Chang CJ), Yu IS, Lee PC, Lee WJ, Yun-Chia Chang E, Chuang LM*  (2012-08)  OBESITY  20(8), 1558-1565  "The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human"
  11. Yu-Lun Su, Shun-Chang Wang, Pei-Yu Chiang, Nien-Yi Lin, Yu-Fang Shen, Geen-Dong Chang, and (Ching-Jin Chang*)  (2012-07)  PLoS One  7(7), e41313  "Tristetraprolin Inhibits Poly(A)-Tail Synthesis in Nuclear mRNA That Contains AU-rich Elements by Interacting with Poly(A)-Binding Protein Nuclear 1 "
  12. Lin NY, Lin TY, Yang WH, Wang SC, Wang KT, Su YL, Jiang YW, Chang GD, (Chang CJ*).  (2012-05)  International Journal of Biological Sciences  8(5), 761-777  "Differential Expression and Functional Analysis of the Tristetraprolin Family during Early Differentiation of 3T3-L1 Preadipocytes."
  13. Yeh PA, Yang WH, Chiang PY, Wang SC, Chang MS, (Chang CJ*)  (2012-04)  International Journal of Biological Sciences  8(5), 606-619  "Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11"
  14. Yeh PA, (Chang CJ), Tu PH, Wilson HI, Chien JY, Tang CY, Su MT  (2010)  Journal of Alzheimer's disease : JAD  21(2), 543-556  "Phosphorylation alters tau distribution and elongates life span in Drosophila."
  15. Nien-Yi Lin, Tzi-Yang Lin, Ching-Jin Chang, and Chung-Tien Lin  (2009-09)  Taiwan Veterinary Journal.  35(3), 174-184  "Analysis of ARE-binding proteins associated with 3’ untranslated region of MKP-1 mRNA"
  16. N.-Y. Lin, C.-T. Lin, and C.-J. Chang  (2008)  Biochemical and Biophysical Research Communications  365, 69-74  "Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells"
  17. Chiung-Wen Chang, Han-Yi Chou, Yu-Sheng Lin, Kuo-Hsiang Huang, (Ching-Jin Chang), Tsui-Chun Hsu and Sheng-Chung Lee  (2008)  BMC Molecular Biology  9, 61  "Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1."
  18. N.-Y. Lin, C.-T. Lin, Y.-L. Chen and C.-J. Chang  (2007)  FEBS J  274, 867-878  "Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes"
  19. Y.L. Chen, Y.L. Huang, N.Y. Lin, H.C. Chen and C.J. Chang  (2006)  Biochemical and Biophysical Research Communications  346(1), 160-168  "Differential regulation of ARE-mediated TNFalpha and IL-1beta mRNA stability by lipopolysaccharide in RAW264.7 cells."
  20. W.Y. Yang, C.H. Liu, C.J. Chang, L.C. Lee, K.J. Chang and C.T. Lin  (2006)  Journal of Comparative Pathology  134, 70-79  "Proliferative activity, apoptosis and expression of oestrogen receptor and Bcl-2 oncoprotein in canine mammary gland tumours"
  21. J.L. Lee, C.J. Chang, L.L. Chueh and C.T. Lin  (2006)  Breast Cancer Research and Treatment  100, 49-58  "Secreted Frizzled Related Protein 2 (sFRP2) Decreases Susceptibility to UV-Induced Apoptosis in Primary Culture of Canine Mammary Gland Tumors by NF-kappaB Activation or JNK Suppression"
  22. J. L. Lee, C. T. Lin, L. L. Chueh and C. J. Chang  (2004)  J Biol Chem  279, 14602-14609  "Autocrine/paracrine SFRP2 induces cellular resistance to apoptosis: A possible mechanism of mammary tumorigenesis"
  23. Lee JL, Chang CJ, Wu SY, Sargan DR, Lin CT  (2004)  Breast cancer research and treatment  84(2), 139-149  "Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands."
  24. Su WC, Chou HY, Chang CJ, Lee YM, Chen WH, Huang KH, Lee MY, Lee SC  (2003)  The Journal of biological chemistry  278(51), 51150-51158  "Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene."
  25. J. L. Lee, C. J. Chang, L. L. Chueh and C. T. Lin  (2003)  In Vitro Cellular & Developmental Biology-Animal  39(5-6), 221-227  "Expression of secreted frizzled-related protein 2 in a primary canine mammary tumor cell line: a candidate tumor marker for mammary tumor cells"
  26. H. C. Chen, W. C. Lin, Y. G. Tsay, S. C. Lee and C. J. Chang*  (2002)  J Biol Chem  277, 40403-40409  "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K"
  27. C. M. Chiu, Y. G. Tsay, C. J. Chang and S. C. Lee  (2002)  J Biol Chem  277, 39102-39111  "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene"
  28. W. C. Lin, B. J. Shen, Y. G. Tsay, H. C. Yen, S. C. Lee and C. J. Chang  (2002)  DNA Cell Biol  21, 551-560  "Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2"
  29. C. J. Chang, H. W. Luh, S. H. Wang, H. J. Lin, S. C. Lee and S. T. Hu  (2001)  DNA Cell Biol  20, 569-577  "The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein"
  30. C. J. Chang, Y. L. Chen and S. C. Lee  (1998)  Mol Cell Biol  18, 5880-5887  "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression"
  31. L. H. Miau, C. J. Chang, B. J. Shen, W. H. Tsai and S. C. Lee  (1998)  J Biol Chem  273, 10784-10791  "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation"
  32. L. H. Miau, C. J. Chang, W. H. Tsai and S. C. Lee  (1997)  Mol Cell Biol  17, 230-239  "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor"
  33. B. J. Shen, C. J. Chang, H. S. Lee, W. H. Tsai, L. H. Miau and S. C. Lee  (1997)  DNA Cell Biol  16, 703-711  "Transcriptional induction of the agp/ebp (c/ebp beta) gene by hepatocyte growth factor"
  34. Lee YM, Miau LH, Chang CJ, Lee SC  (1996)  Molecular and cellular biology  16(8), 4257-4263  "Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140."
  35. C. J. Chang, B. J. Shen and S. C. Lee  (1995)  DNA Cell Biol  14, 529-537  "Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp"
  36. Chang CJ, Lai MY, Chen DS, Lee SC  (1992)  DNA and cell biology  11(4), 315-320  "Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3)."
  37. C. J. Chang, T. T. Chen, H. Y. Lei, D. S. Chen and S. C. Lee  (1990)  Mol Cell Biol  10, 6642-6653  "Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family"
  38. S. C. Lee, C. J. Chang, Y. M. Lee, H. Y. Lei, M. Y. Lai and D. S. Chen  (1989)  DNA  8, 245-251  "Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse"

The tristetraprolin (TTP) family, which regulates mRNA decay, comprises three members in humans and four in rodents. The three related proteins are TTP (also named ZFP36, TIS11), ZFP36L1 (TIS11B, BRF1), and ZFP36L2 (TIS11D, BRF2). We have demonstrated that they play functions in macrophage activation and adipogenesis through destabilization of target mRNAs. Zfp36l3 is a rodent-specific gene, only expressed in the placenta and extraembryonic tissues of mice. All TTP family members have a highly conserved (70% identity) tandem zinc finger (TZF) domain, which is responsible for high-affinity binding to AU-rich elements (AREs) of mRNAs. In eukaryotes, mRNA decay is initiated by deadenylation and the activation of two major decay pathways from the 3′ to the 5′ end or from the 5′ to the 3′ end. Mammalian mRNA deadenylation involved two consecutive phases mediated by the PAN2-PAN3 and the CCR4-NOT complexes, respectively. Recent work indicates that TTP can recruit the CCR4/CAF1/NOT deadenylase complex through direct interaction with CNOT1, resulting in decay of ARE-containing reporter mRNAs. TTP family members share TTP-like activities and promote the deadenylation and destruction of ARE-containing target sequences. However, what specificity in the recruitment of CCR4 and CAF1 paralogs for the individual TTP family member and what the mechanism for the differential role in mRNA deadenylation of the CCR4 and CAF1 deadenylases is unclear. Moreover, how the protein phosphorylation of TTP family involved in deadenylases association is to be investigated.

Positions Held
  • 2002 – present   Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1994 – 2002   Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
  • 1989 – 1994   Research Assistant, Institute of Biological Chemistry, Academia Sinica
Degrees
  • 1990 – 1994   Ph.D., Institute of Biochemical Sciences, National Taiwan University
  • 1987 – 1989   M.S., Institute of Biochemical Sciences, National Taiwan University
  • 1983 – 1987   B.S., Department of Agricultural Chemistry,, National Taiwan University
Chiang, P.Y., Shen, Y.F., Kao, C.H., Su, Y.L., Lin, N.Y., Hsu, P.H., Tsai, M.D., Wang, S.C., Chang, G.D., Lee, S.C., and Chang, C.J.
PLos One (2013)
Yang, F.C., Tan, B., Chen, W.H., Lin, Y.H., Huang, J.Y., Chang, H.Y., Sun, H.Y., Hsu, P.H., Liou, G.G., Shen, J., Chang, C.J., Han, C.C., Tsai, M.D., and Lee, S.C.
Journal of Biological Chemistry (2013)
Chen, Y.L., Jiang, Y.W., Su, Y.L., Lee, S.C., Chang, M.S., and Chang C.J.
Molecular biology reports (2013)
Lin, N.Y., Lin, T.Y., Yang, W.H., Wang, S.C., Wang, K.T., Su, Y.L., Jiang, Y.W., Chang, G.D., and Chang, C.J.
International journal of biological sciences (2012)
Yeh, P.A., Yang, W.H., Chiang, P.Y., Wang, S.C., Chang, M.S. and Chang, C.J.
International journal of biological sciences (2012)
Hee, S.W., Tsai, S.H., Chang, Y.C., Chang, C.J., Yu, I.S., Lee, P.C., Lee, W.J., Yun-Chia Chang, E. and Chuang, L.M.
Obesity (Silver Spring) (2012)
Su, Y.L., Wang, S.C., Chiang, P.Y., Lin, N.Y., Shen, Y.F., Chang, G.D., and Chang C.J.
PLoS One (2012)
Lin, N.Y., Lin, C.T. and Chang, C.J.
Biochemical and biophysical research communications (2008)
Lin, N.Y., Lin, C.T., Chen, Y.L. and Chang, C.J.
The FEBS journal (2007)
Chen, Y.L., Huang, Y.L., Lin, N.Y., Chen, H.C., Chiu, W.C. and Chang, C.J.
Biochemical and biophysical research communications (2006)
  1. Yeh CC, (Chang CJ), Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, Yu LC  (2018-08)  Blood advances  2(15), 1854-1864  "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
  2. Yeh CC, (Chang CJ), Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, Yu LC  (2018-04)  Transfusion  58(4), 1054-1064  "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
  3. Yeh PA, (Chang CJ)  (2017)  PLOS ONE  12(10), e0186037  "A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization."
  4. Wang HH, Lin CY, Su SH, Chuang CT, Chang YL, Lee TY, Lee SC, (Chang CJ)  (2016)  Cell Death and Disease  7(7), e2298  "Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis."
  5. Wang KT, Wang HH, Wu YY, Su YL, Chiang PY, Lin NY, Wang SC, Chang GD, (Chang CJ)*   (2015-07)  Journal of Inflammation-London  12, 42  " Functional regulation of Zfp36l1 and Zfp36l2 in response to lipopolysaccharide in mouse RAW264.7 macrophages."
  6. Chiang PY, Shen YF, Su YL, Kao CH, Lin NY, Hsu PH, Tsai MD, Wang SC, Chang GD, Lee SC, (Chang CJ)  (2013-04)  PloS one  8(4), e61697  "Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes."
  7. Yu-Ling Chen, Yu-Wun Jiang, Yu-Lun Su, Sheng-Chung Lee, Mau-Sun Chang and (Ching-Jin Chang)*  (2013-04)  MOLECULAR BIOLOGY REPORTS  40(4), 2867-2877  "Transcriptional Regulation of Tristetraprolin by NF-κB Signaling in LPS-stimulated Macrophages"
  8. Yang FC, Tan BC, Chen WH, Lin YH, Huang JY, Chang HY, Sun HY, Hsu PH, Liou GG, Shen J, (Chang CJ), Han CC, Tsai MD, Lee SC  (2013)  The Journal of biological chemistry  288(9), 6227-6237  "Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy."
  9. Hu CK, Lee YJ, Colitz CM, (Chang CJ), Lin CT*  (2012-09)  VETERINARY OPHTHALMOLOGY  15(s2), 65-71  "The protective effects of Lycium barbarum and Chrysanthemum morifolum on diabetic retinopathies in rats"
  10. Hee SW, Tsai SH, Chang YC, (Chang CJ), Yu IS, Lee PC, Lee WJ, Yun-Chia Chang E, Chuang LM*  (2012-08)  OBESITY  20(8), 1558-1565  "The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human"
  11. Yu-Lun Su, Shun-Chang Wang, Pei-Yu Chiang, Nien-Yi Lin, Yu-Fang Shen, Geen-Dong Chang, and (Ching-Jin Chang*)  (2012-07)  PLoS One  7(7), e41313  "Tristetraprolin Inhibits Poly(A)-Tail Synthesis in Nuclear mRNA That Contains AU-rich Elements by Interacting with Poly(A)-Binding Protein Nuclear 1 "
  12. Lin NY, Lin TY, Yang WH, Wang SC, Wang KT, Su YL, Jiang YW, Chang GD, (Chang CJ*).  (2012-05)  International Journal of Biological Sciences  8(5), 761-777  "Differential Expression and Functional Analysis of the Tristetraprolin Family during Early Differentiation of 3T3-L1 Preadipocytes."
  13. Yeh PA, Yang WH, Chiang PY, Wang SC, Chang MS, (Chang CJ*)  (2012-04)  International Journal of Biological Sciences  8(5), 606-619  "Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11"
  14. Yeh PA, (Chang CJ), Tu PH, Wilson HI, Chien JY, Tang CY, Su MT  (2010)  Journal of Alzheimer's disease : JAD  21(2), 543-556  "Phosphorylation alters tau distribution and elongates life span in Drosophila."
  15. Nien-Yi Lin, Tzi-Yang Lin, Ching-Jin Chang, and Chung-Tien Lin  (2009-09)  Taiwan Veterinary Journal.  35(3), 174-184  "Analysis of ARE-binding proteins associated with 3’ untranslated region of MKP-1 mRNA"
  16. N.-Y. Lin, C.-T. Lin, and C.-J. Chang  (2008)  Biochemical and Biophysical Research Communications  365, 69-74  "Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells"
  17. Chiung-Wen Chang, Han-Yi Chou, Yu-Sheng Lin, Kuo-Hsiang Huang, (Ching-Jin Chang), Tsui-Chun Hsu and Sheng-Chung Lee  (2008)  BMC Molecular Biology  9, 61  "Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1."
  18. N.-Y. Lin, C.-T. Lin, Y.-L. Chen and C.-J. Chang  (2007)  FEBS J  274, 867-878  "Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes"
  19. Y.L. Chen, Y.L. Huang, N.Y. Lin, H.C. Chen and C.J. Chang  (2006)  Biochemical and Biophysical Research Communications  346(1), 160-168  "Differential regulation of ARE-mediated TNFalpha and IL-1beta mRNA stability by lipopolysaccharide in RAW264.7 cells."
  20. W.Y. Yang, C.H. Liu, C.J. Chang, L.C. Lee, K.J. Chang and C.T. Lin  (2006)  Journal of Comparative Pathology  134, 70-79  "Proliferative activity, apoptosis and expression of oestrogen receptor and Bcl-2 oncoprotein in canine mammary gland tumours"
  21. J.L. Lee, C.J. Chang, L.L. Chueh and C.T. Lin  (2006)  Breast Cancer Research and Treatment  100, 49-58  "Secreted Frizzled Related Protein 2 (sFRP2) Decreases Susceptibility to UV-Induced Apoptosis in Primary Culture of Canine Mammary Gland Tumors by NF-kappaB Activation or JNK Suppression"
  22. J. L. Lee, C. T. Lin, L. L. Chueh and C. J. Chang  (2004)  J Biol Chem  279, 14602-14609  "Autocrine/paracrine SFRP2 induces cellular resistance to apoptosis: A possible mechanism of mammary tumorigenesis"
  23. Lee JL, Chang CJ, Wu SY, Sargan DR, Lin CT  (2004)  Breast cancer research and treatment  84(2), 139-149  "Secreted frizzled-related protein 2 (SFRP2) is highly expressed in canine mammary gland tumors but not in normal mammary glands."
  24. Su WC, Chou HY, Chang CJ, Lee YM, Chen WH, Huang KH, Lee MY, Lee SC  (2003)  The Journal of biological chemistry  278(51), 51150-51158  "Differential activation of a C/EBP beta isoform by a novel redox switch may confer the lipopolysaccharide-inducible expression of interleukin-6 gene."
  25. J. L. Lee, C. J. Chang, L. L. Chueh and C. T. Lin  (2003)  In Vitro Cellular & Developmental Biology-Animal  39(5-6), 221-227  "Expression of secreted frizzled-related protein 2 in a primary canine mammary tumor cell line: a candidate tumor marker for mammary tumor cells"
  26. H. C. Chen, W. C. Lin, Y. G. Tsay, S. C. Lee and C. J. Chang*  (2002)  J Biol Chem  277, 40403-40409  "An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K"
  27. C. M. Chiu, Y. G. Tsay, C. J. Chang and S. C. Lee  (2002)  J Biol Chem  277, 39102-39111  "Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene"
  28. W. C. Lin, B. J. Shen, Y. G. Tsay, H. C. Yen, S. C. Lee and C. J. Chang  (2002)  DNA Cell Biol  21, 551-560  "Transcriptional activation of C/EBPbeta gene by c-Jun and ATF2"
  29. C. J. Chang, H. W. Luh, S. H. Wang, H. J. Lin, S. C. Lee and S. T. Hu  (2001)  DNA Cell Biol  20, 569-577  "The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein"
  30. C. J. Chang, Y. L. Chen and S. C. Lee  (1998)  Mol Cell Biol  18, 5880-5887  "Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression"
  31. L. H. Miau, C. J. Chang, B. J. Shen, W. H. Tsai and S. C. Lee  (1998)  J Biol Chem  273, 10784-10791  "Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation"
  32. L. H. Miau, C. J. Chang, W. H. Tsai and S. C. Lee  (1997)  Mol Cell Biol  17, 230-239  "Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor"
  33. B. J. Shen, C. J. Chang, H. S. Lee, W. H. Tsai, L. H. Miau and S. C. Lee  (1997)  DNA Cell Biol  16, 703-711  "Transcriptional induction of the agp/ebp (c/ebp beta) gene by hepatocyte growth factor"
  34. Lee YM, Miau LH, Chang CJ, Lee SC  (1996)  Molecular and cellular biology  16(8), 4257-4263  "Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140."
  35. C. J. Chang, B. J. Shen and S. C. Lee  (1995)  DNA Cell Biol  14, 529-537  "Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp"
  36. Chang CJ, Lai MY, Chen DS, Lee SC  (1992)  DNA and cell biology  11(4), 315-320  "Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3)."
  37. C. J. Chang, T. T. Chen, H. Y. Lei, D. S. Chen and S. C. Lee  (1990)  Mol Cell Biol  10, 6642-6653  "Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family"
  38. S. C. Lee, C. J. Chang, Y. M. Lee, H. Y. Lei, M. Y. Lai and D. S. Chen  (1989)  DNA  8, 245-251  "Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse"