Molecular Genetics of the Human Red Cell Antigens.
Our laboratory is interested in the molecular genetic bases responsible for the polymorphisms of the human red cell surface antigens; especially interested in the antigens with carbohydrate structure. The research topics that we have implemented during these years include: the ABO blood group glycosyltransferase genes and the rare ABO blood types, Secretor a-1,2-fucosyltransferase gene and the Lewis antigen phenotypes, and the molecular genetics of the I b-1,6-N-acetylglucosaminyltransferase locus and the partial association with congenital cataracts. The expression profiles of the carbohydrate antigens during cell differentiation processes and the regulatory mechanisms of the related glycosyltransferase genes are also our research interests. Currently we endeavor to elucidate the molecular genetic basis for the polymorphism of the P1 (Gala1-4GalNAcb1-3Gal) antigen on red cell surfaces and the expression of I branching carbohydrate structure and the regulatory mechanisms of the I gene transcription during cell differentiation.
Molecular Genetics of the Human Red Cell Antigens.
Our laboratory is interested in the molecular genetic bases responsible for the polymorphisms of the human red cell surface antigens; especially interested in the antigens with carbohydrate structure. The research topics that we have implemented during these years include: the ABO blood group glycosyltransferase genes and the rare ABO blood types, Secretor a-1,2-fucosyltransferase gene and the Lewis antigen phenotypes, and the molecular genetics of the I b-1,6-N-acetylglucosaminyltransferase locus and the partial association with congenital cataracts. The expression profiles of the carbohydrate antigens during cell differentiation processes and the regulatory mechanisms of the related glycosyltransferase genes are also our research interests. Currently we endeavor to elucidate the molecular genetic basis for the polymorphism of the P1 (Gala1-4GalNAcb1-3Gal) antigen on red cell surfaces and the expression of I branching carbohydrate structure and the regulatory mechanisms of the I gene transcription during cell differentiation.
Positions Held
- 2008 – present Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
- 2008 – present Joint Appointment Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
- 2003 – 2008 Joint Appointment Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
- 2002 – 2008 Associate Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
- 1998 – 2002 Investigator, Dept. of Medical Research, Mackay Memorial Hospital
- 1993 – 1997 Associate Investigator, Dept. of Medical Research, Mackay Memorial Hospital
Degrees
- 1989 – 1994 Ph.D., Graduate Institute of Biochemical Sciences, National Taiwan University
- 1985 – 1987 M.S., Graduate Institute of Biochemical Sciences, National Taiwan University
- 1981 – 1985 B.S., Department of Zoology, National Taiwan University
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Yeh CC, Chang CJ, Twu YC, Chu CC, Liu BS, Huang JT, Hung ST, Chan YS, Tsai YJ, Lin SW, Lin M, (Yu LC) (2018-08) Blood advances 2(15), 1854-1864 "The molecular genetic background leading to the formation of the human erythroid-specific Xg(a)/CD99 blood groups."
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Yeh CC, Chang CJ, Twu YC, Hung ST, Tsai YJ, Liao JC, Huang JT, Kao YH, Lin SW, (Yu LC) (2018-04) Transfusion 58(4), 1054-1064 "The differential expression of the blood group P(1) -A4GALT and P(2) -A4GALT alleles is stimulated by the transcription factor early growth response 1."
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Chen PT, Chen ZT, Hou WC, (Yu LC), Chen RP (2016-07) Scientific reports 6, 29760 "Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease."
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Lai YJ, Wu WY, Yang CM, Yang LR, Chu CC, Chan YS, Lin M, (Yu LC) (2014-12) Transfusion 54(12), 3222-3231 "A systematic study of single-nucleotide polymorphisms in the A4GALT gene suggests a molecular genetic basis for the P1 /P2 blood groups."
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Lu CH, Wu WY, Lai YJ, Yang CM, (Yu LC) (2014-04) Glycobiology 24(4), 359-367 "Suppression of B3GNT7 gene expression in colon adenocarcinoma and its potential effect in the metastasis of colon cancer cells."
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Li PT, Liao CJ, (Yu LC), Wu WG, Chu ST (2012-05) Fertility and sterility 97(5), 1206-1212.e3 "Localization of B4GALNT2 and its role in mouse embryo attachment."
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(Yu LC), Lin M (2011-11) Current opinion in hematology 18(6), 421-6 "Molecular genetics of the blood group I system and the regulation of I antigen expression during erythropoiesis and granulopoiesis."
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Li PT, Liao CJ, Wu WG, (Yu LC), Chu ST (2011-06) Fertility and sterility 95(7), 2404-2409.e3 "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice."
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Twu YH, Hsieh CY, Lin M, Tzeng CH, Sun CF, (Yu LC)* (2010-03) Blood 115(12), 2491 - 2499 "Phosphorylation status of transcription factor C/EBPα determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis"
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Lin CH, Fan YY, Chen YY, Wang SH, Chen CI, (Yu LC), Khoo KH (2009) Glycobiology 19(4), 418-27 "Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines."
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H. R. Wang, C. Y. Hsieh, Y. C. Twu and L. C. Yu (2008) Glycobiology 18(1), 104-113 "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status."
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Lin M, Yu LC (2008) Transfusion 48(8), 1768 "Frequencies of the JKnull (IVS5-1g>a) allele in Taiwanese, Fujian, Filipino, and Indonesian populations."
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Y. Y. Fan, S. Y. Yu, H. Ito, K. Akihiko, T. Sato, C. H. Lin, L. C. Yu, H. Narimatsu and K. H. Khoo (2008) J Biol Chem 283(24), 16455-16468 "Identification of further elongation and branching of dimeric type 1 chain on lactosylceramides from colonic adenocarcinoma by tandem mass spectrometry sequencing analyses"
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Y. C. Twu, C. P. Chen, C. Y. Hsieh, C. H. Tzeng, C. F. Sun, S. H. Wang, M. S. Chang and L. C. Yu (2007) Blood 110(13), 4526-4534 "I branching formation in erythroid differentiation is regulated by transcription factor C/EBP{alpha}"
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Lin M, Hou MJ, (Yu LC) (2006) Transfusion 46(11), 1982-7 "A novel IGnT allele responsible for the adult i phenotype."
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Twu YC, Hsieh CY, (Yu LC) (2006) Transfusion 46(11), 1988-96 "Expression of the histo-blood group B gene predominates in AB-genotype cells."
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C. F. Sun, L. C. Yu, D. P. Chen, M. L. Chou, Y. C. Twu, W. T. Wang and M. Lin (2003) Transfusion 43, 1138-1144 "Molecular genetic analysis for the Ael and A3 alleles"
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C. F. Sun, D. P. Chen, K. T. Lin, W. T. Wang, Y. C. Wang and L. C. Yu (2003) Vox Sang 85, 216-220 "Molecular genetic analysis of the Bel phenotype"
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L. C. Yu, Y. C. Twu, M. L. Chou, M. E. Reid, A. R. Gray, J. M. Moulds, C. Y. Chang and M. Lin (2003) Blood 101, 2081-2088 "The Molecular Genetics of the Human I Locus and Molecular Background Explain the Partial Association of the Adult i Phenotype with Congenital Cataracts"
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Y. C. Twu, M. L. Chou and L. C. Yu (2003) Biochem Biophys Res Commun 303, 868-876 "The molecular genetics of the mouse I b-1,6-N-acetylglucosaminyltransferase locus"
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L. C. Yu, Y. C. Twu, M. L. Chou, C. Y. Chang, C. Y. Wu and M. Lin (2002) Blood 100, 1490-1492 "Molecular genetic analysis for the B(3) allele"
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L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin (2001) Blood 98, 3840-3845 "Molecular Basis of the Adult i Phenotype and the Gene Responsible for the Expression of Human Blood Group I Antigen"
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L. C. Yu, Y. C. Twu, C. Y. Chang and M. Lin (2001) J Biol Chem 276, 10247-10252 "Molecular Basis of the Kell-null Phenotype: A Mutation at the Splice Site of Human KEL Gene Abolishes the Expression of Kell Blood Group Antigens"
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L. C. Yu, C. C. Chu, Y. S. Chan, C. Y. Chang, Y. C. Twu and M. Lin (2001) Transfusion 41, 1279-1284 "Polymorphism and Distribution of the Secretor a(1,2)-Fucosyltransferase Gene in Various Taiwanese Populations"
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L. C. Yu, C. Y. Chang, Y. C. Twu and M. Lin (2000) Biochem Biophys Res Commun 273, 459-466 "Human Histo-blood Group ABO Glycosyltransferase Genes: Different Enhancer Structures with Different Transcriptional Activities"
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L. C. Yu, H. L. Lee, C. C. Chu, R. E. Broadberry and M. Lin (1999) Vox Sang 76, 115-119 "A Newly Identified Nonsecretor Allele of the Human Histo-Blood Group a(1,2)-Fucosyltransferase Gene (FUT2)"
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L. C. Yu, H. L. Lee, Y. S. Chan and M. Lin (1999) Biochem Biophys Res Commun 262, 487-493 "The Molecular Basis for the B(A) Allele: An Amino Acid Alteration in the Human Histoblood Group B a-(1,3)-Galactosyltransferase Increase Its Intrinsic a-(1,3)-N-Acetylgalactosaminyltransferase Activity"
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L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen and M. Lin (1997) Vox Sang 72, 36-40 "Heterogeneity of the Human H Blood Group a(1,2)Fucosyltransferase Gene among para-Bombay Individuals"
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L. C. Yu, Y. L. Hsiao, Y. H. Yang, M. Lin and Y. H. Chen (1997) Biochem Biophys Res Commun 231, 106-110 "The Genomic Structure of a Mouse Seminal Vesicle Autoantigen"
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L. C. Yu, R. E. Broadberry, Y. H. Yang, Y. H. Chen and M. Lin (1996) Biochem Biophys Res Commun 222, 390-394 "Heterogeneity of the Human Secretor a(1,2)Fucosyltransferase Gene among Lewis(a+b-) Non-secretors"
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L. C. Yu, Y. H. Yang, R. E. Broadberry, Y. H. Chen, Y. S. Chan and M. Lin (1995) Biochem J 312, 329-332 "Correlation of a Missense Mutation in the Human Secretor a(1,2)-Fucosyltransferase Gene with the Lewis(a+b+) Phenotype: A Potential Molecular Basis for the Weak Secretor Allele (Sew)"
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Y. H. Huang, C. W. Luo, L. C. Yu, S. T. Chu and Y. H. Chen (1995) Biophys J 69, 2084-2089 "The Protein Conformation and a Zinc-Binding Domain of an Autoantigen from Mouse Seminal Vesicle"
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L. C. Yu, J. L. Chen, W. B. Tsai and Y. H. Chen (1993) Biochem J 296, 571-576 "Primary Structure and Characterization of an Androgen-Stimulated Autoantigen from Mouse Seminal-Vesicle Secretion"
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L. C. Yu and Y. H. Chen (1993) Biochem J 296, 107-111 "The Developmental Profile of Lactoferrin in Mouse Epididymis"