Research

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of both synthetic and bioorganic strategies is paramount to our research. Programmable one-pot reactions and enzymatic synthesis methods are being developed for the synthesis of complex oligosaccharides, homogeneous glycoproteins and glycoarrays. These tools and methods are used to understand the role of glycosylation in virology and to develop new carbohydrate-based medicines

Degrees and Positions Held
Positions Held
  • 2006 – 2016   President, Academia Sinica, Taipei, Taiwan
  • 2003 – 2006   Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
  • 1991 – 1999   Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
  • 1989 – 2006   Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
  • 1983 – 1989   Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
  • 1982 – 1983   Postdoctoral Fellow, Harvard University
Degrees
  • 1979 – 1982   Ph.D, Chemistry, Massachusetts Institute of Technology
Selected Publications
A Common Glycan Structure on Immunoglobulin G for Enhancement of Effector Functions.
Lin CW, Tsai MH, Li ST, Tsai TI, Chu KC, Liu YC, Lai MY, Wu CY, Tseng YC, Shivatare SS, Wang CH, Chao P, Wang SY, Shih HW, Zeng YF, You TH, Liao JY, Tu YC, Lin YS, Chuang HY, Chen CL, Tsai CS, Huang CC, Lin NH, Ma C, Wu CY, and Wong CH.
Proc. Nat. Acad. Sci. U.S.A. (2015)
Modular Synthesis of N-glycans and Arrays for the Hetero-ligand Binding Analysis of HIV Antibodies.
Shivatare S S, Chang SH, Tsai TI, Tseng SY, Lin YS, Cheng YY, Ren Pawar CT, S, Tsai CS, Shi HW, Zeng YF, Liang CH, Kwong PD, Burton DR, Wu CY and Wong CH.
Nature Chemistry (2015)
An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence Upon Triazole Formation.
Shie JJ, Liu YC, Lee YM, Lim C, Fang JM, Wong CH.
J. Am. Chem. Soc. (2014)
Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections.
Chen JR, Yu YH, Tseng YC, Chiang WL, Chiang MF, Ko YA, Chiu YK, Ma SH, Wu CY, Jan JT, Lin KI, Ma C. and Wong CH.
Proc. Nat. Acad. Sci. U.S.A. (2014)
Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.
Huang YL, Hung JT, Cheung SKC, Lee HY, Chu KC, Li ST, Lin YC, Ren CT, Cheng TJR, Hsu TL, Yu AL, Wu CY, Wong CH.
Proc. Natl. Acad. Sci. U.S.A. (2013)
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis.
Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJR, Cheng WC, Wong CH, and Ma C.
Proc. Nat. Acad. Sci. U.S.A. (2012)
Enzymes in the Synthesis of Glycoconjugates.
Schmaltz, R.; Hanson, S.R.; Wong, C.H.
Chemical Reviews (2011)
Toward Automatic Oligosaccharide Synthesis.
Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H.
Angew. Chem. Int. Ed. (2011)
Enzymes for chemical synthesis.
Koeller KM, Wong CH.
Nature (2001)
Toward automated synthesis of oligosaccharides and glycoproteins.
Sears P, Wong CH.
Science (2001)
Publications List
  1. W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCI)
  2. P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(28), 7302-7307. (SCI)
  3. V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, 2018, “Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.”, Journal of the American Chemical Society, 140(15), 5202-5210. (SCI)
  4. Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCI)
  5. T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases.”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCI)
  6. L. Krasnova and C.-H. Wong, 2016, “Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis”, ANNUAL REVIEW OF BIOCHEMISTRY, 85, 599-630. (SCI)
  7. S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, ACCOUNTS OF CHEMICAL RESEARCH, 48(3), 643-652. (SCI)
  8. J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, J. Am. Chem. Soc., 136(28), 9953-9961. (SCI)
  9. Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2482-2487. (SCI)
  10. J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2476-2481. (SCI)
  11. Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-2522. (SCI)
  12. C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(2), 630-635. (SCI)
  13. C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(17), 6496-6501. (SCI)
  14. K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, 2011, “Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(40), 9391-9395. (SCI)
  15. Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11332-11337. (SCI)
  16. Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, and M.-D. Tsai, 2011, “E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(40), 16515-16520. (SCI)
  17. E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, 2011, “Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns”, Science, 331(6017), 571-575. (SCI)
  18. C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
  19. S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, J. Am. Chem. Soc, 132(38),13371-13380. (SCI)
  20. S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, 2009, “The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(9), 3131-3136. (SCI)
  21. C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik and C.-H. Wong, 2008, “Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(36), 11945-11952. (SCI)
  22. T. L. Hsu, S. R. Hanson, K. Kishikawa, S. K. Wang, M. Sawa and C. H. Wong, 2007, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 2614-2619. (SCI)
  23. M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(33), 12371-12376. (SCI)
  24. O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, 2004, “Printed covalent glycan array for ligand profiling of diverse glycan binding proteins”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 17033-17038. (SCI)
  25. K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, NATURE, 409, 232-240. (SCI)
  26. A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, SCIENCE, 294, 369-374. (SCI)
  27. P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, SCIENCE, 291, 2344-2350. (SCI)

Chemical Biology and Drug Discovery

Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of both synthetic and bioorganic strategies is paramount to our research. Programmable one-pot reactions and enzymatic synthesis methods are being developed for the synthesis of complex oligosaccharides, homogeneous glycoproteins and glycoarrays. These tools and methods are used to understand the role of glycosylation in virology and to develop new carbohydrate-based medicines

Positions Held
  • 2006 – 2016   President, Academia Sinica, Taipei, Taiwan
  • 2003 – 2006   Director, The Genomic Research Center, Acadmia Sinica, Taipei, Taiwan
  • 1991 – 1999   Head, Frontier Research Program on Glycotechnolgy, Institute of Physical and Chemical Research (RIKEN), Japan
  • 1989 – 2006   Professor and Ernest W. Hahn Chair in Chemistry, The ScripScripps Research Institute
  • 1983 – 1989   Assistant Professor through Professor of Chemistry and Biochemistry, Texas A&M University
  • 1982 – 1983   Postdoctoral Fellow, Harvard University
Degrees
  • 1979 – 1982   Ph.D, Chemistry, Massachusetts Institute of Technology
A Common Glycan Structure on Immunoglobulin G for Enhancement of Effector Functions.
Lin CW, Tsai MH, Li ST, Tsai TI, Chu KC, Liu YC, Lai MY, Wu CY, Tseng YC, Shivatare SS, Wang CH, Chao P, Wang SY, Shih HW, Zeng YF, You TH, Liao JY, Tu YC, Lin YS, Chuang HY, Chen CL, Tsai CS, Huang CC, Lin NH, Ma C, Wu CY, and Wong CH.
Proc. Nat. Acad. Sci. U.S.A. (2015)
Modular Synthesis of N-glycans and Arrays for the Hetero-ligand Binding Analysis of HIV Antibodies.
Shivatare S S, Chang SH, Tsai TI, Tseng SY, Lin YS, Cheng YY, Ren Pawar CT, S, Tsai CS, Shi HW, Zeng YF, Liang CH, Kwong PD, Burton DR, Wu CY and Wong CH.
Nature Chemistry (2015)
An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence Upon Triazole Formation.
Shie JJ, Liu YC, Lee YM, Lim C, Fang JM, Wong CH.
J. Am. Chem. Soc. (2014)
Vaccination of Monoglycosylated Hemagglutinin Induces Cross-Strain Protection against Influenza Virus Infections.
Chen JR, Yu YH, Tseng YC, Chiang WL, Chiang MF, Ko YA, Chiu YK, Ma SH, Wu CY, Jan JT, Lin KI, Ma C. and Wong CH.
Proc. Nat. Acad. Sci. U.S.A. (2014)
Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.
Huang YL, Hung JT, Cheung SKC, Lee HY, Chu KC, Li ST, Lin YC, Ren CT, Cheng TJR, Hsu TL, Yu AL, Wu CY, Wong CH.
Proc. Natl. Acad. Sci. U.S.A. (2013)
Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis.
Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJR, Cheng WC, Wong CH, and Ma C.
Proc. Nat. Acad. Sci. U.S.A. (2012)
Enzymes in the Synthesis of Glycoconjugates.
Schmaltz, R.; Hanson, S.R.; Wong, C.H.
Chemical Reviews (2011)
Toward Automatic Oligosaccharide Synthesis.
Hsu, C.H.; Hung, S.C.; Wu, C.Y.; Wong, C.H.
Angew. Chem. Int. Ed. (2011)
Enzymes for chemical synthesis.
Koeller KM, Wong CH.
Nature (2001)
Toward automated synthesis of oligosaccharides and glycoproteins.
Sears P, Wong CH.
Science (2001)
  1. W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140(8), 2752-2755. (SCI)
  2. P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(28), 7302-7307. (SCI)
  3. V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, 2018, “Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies.”, Journal of the American Chemical Society, 140(15), 5202-5210. (SCI)
  4. Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCI)
  5. T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases.”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCI)
  6. L. Krasnova and C.-H. Wong, 2016, “Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis”, ANNUAL REVIEW OF BIOCHEMISTRY, 85, 599-630. (SCI)
  7. S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, 2015, “Development of Globo-H Cancer Vaccine”, ACCOUNTS OF CHEMICAL RESEARCH, 48(3), 643-652. (SCI)
  8. J.-J. Shie, Y.-C. Liu, Y.−M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, 2014, “An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation”, J. Am. Chem. Soc., 136(28), 9953-9961. (SCI)
  9. Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2482-2487. (SCI)
  10. J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, 2014, “Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(7), 2476-2481. (SCI)
  11. Y.-L. Huang, J.-T. Hung, S. K.C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong, 2013, “Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(7), 2517-2522. (SCI)
  12. C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, 2013, “Fucosyltransferase 8 as a Functional Regulator of Non-Small Cell Lung Cancer”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(2), 630-635. (SCI)
  13. C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, 2012, “Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(17), 6496-6501. (SCI)
  14. K.-C. Chu, C.-T. Ren, C.-P. Lu, C.-H. Hsu, T.-H. Sun, T.-A. Chao, Y.-F. Lin, S.-H. Wu, C.-H. Wong and C.-Y. Wu, 2011, “Efficient and Stereoselective Synthesis of α(2→9) Oligosialic Acids Up to Dodecamer”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(40), 9391-9395. (SCI)
  15. Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, 2011, “Sialylation and Fucosylation of Epidermal Growth Factor Receptor Suppress its Dimerization and Activation in Lung Cancer Cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11332-11337. (SCI)
  16. Y.-F. Shen, Y.-H. Chen, S.-Y. Chu, M.-I. Lin, H.-T. Hsu, P.-Y. Wu, C.-J. Wu, H.-W. Liu, F.-Y. Lin, G. Lin, P.-H. Hsu, A.-S. Yang, Y.-S. E. Cheng, Y.-T. Wu, C.-H. Wong, and M.-D. Tsai, 2011, “E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(40), 16515-16520. (SCI)
  17. E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.‐H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, 2011, “Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns”, Science, 331(6017), 571-575. (SCI)
  18. C.-H. Hsu, S.-C. Hung, C.-Y. Wu, and C.-H. Wong, 2011, “Toward Automated Oligosaccharide Synthesis”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(50), 11872-11923. (SCI)
  19. S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, 2010, “Glycan Array on Aluminum Oxide Coated Glass Slides Through Phosphonate Chemistry”, J. Am. Chem. Soc, 132(38),13371-13380. (SCI)
  20. S. R. Hanson, E. K. Culyba, T. L. Hsu, C.-H. Wong, J. W. Kelly, E. T. Powers, 2009, “The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(9), 3131-3136. (SCI)
  21. C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik and C.-H. Wong, 2008, “Sugar-assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations”, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(36), 11945-11952. (SCI)
  22. T. L. Hsu, S. R. Hanson, K. Kishikawa, S. K. Wang, M. Sawa and C. H. Wong, 2007, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 2614-2619. (SCI)
  23. M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(33), 12371-12376. (SCI)
  24. O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, 2004, “Printed covalent glycan array for ligand profiling of diverse glycan binding proteins”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 17033-17038. (SCI)
  25. K. M. Koeller, C. H. Wong, 2001, “Enzymes for chemical synthesis”, NATURE, 409, 232-240. (SCI)
  26. A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C. H. Wong and I. A. Wilson, 2001, “Observation of covalent intermediates in an enzyme mechanism at atomic resolution”, SCIENCE, 294, 369-374. (SCI)
  27. P. Sears, C. H. Wong, 2001, “Toward automated synthesis of oligosaccharides and glycoproteins”, SCIENCE, 291, 2344-2350. (SCI)