20200824 highlightss

Laying the Foundation for Deep Carbon Reduction! Academia Sinica Creates the First “Synthetic Methylotropic Single Strain”

Frederic Y-H Chen, Hsin-Wei Jung, Chao-Yin Tsuei, James C Liao*
Amidst the raging COVID-19 pandemic, the world remains under the unceasing threat of climate change. Academia Sinica President James C. Liao and his research team have successfully utilized laboratory evolution to isolate the first “synthetic methylotropic single strain”. Their research identified key enzymes with a unique metabolic calculation model and modified e. coli through gene editing. Synthetic methylotrophs can convert methanol into high value chemicals, medicines, and fuels, forming a carbon cycle with high green economic value that will be beneficial for carbon reduction in the future.

20200602 Khoo KH research highlight s

Mass Spec-based ID of site-specific glycosylation

Chu-Wei Kuo and Kay-Hooi Khoo*
Delineating multiple N- and O-glycosylation sites on single glycopeptides and deriving more glycan structure information to discriminate isomeric glycoforms are practical problems to be tackled. Negative mode MS2/MS3 fragmentation was investigated and developed to supplement current nanoLC-MS2-based sequencing and identification of intact glycopeptides largely performed in positive mode.

20200522 Research Highlight s

Discovery of a dual function enzyme that catalyzes enyne formation in cyclohexanoid terpenoid biosynthesis

Yu-Rong Chen, Annavareddi Naresh, Suh-Yuen Liang, Chun-Hung Lin, Rong-Jie Chein*, Hsiao-Ching Lin*
A collaborative research between two teams led by Dr. Hsiao-Ching Lin, an assistant research fellow at the Institute of Biological Chemistry, and Dr. Rong-Jie Chein, an associate research fellow at the Institute of Chemistry,

Hsu 20200103 papers

Through the looking glass of cryoEM, unveiling the unique molecular structure and camouflaging sugar coating of feline coronavirus surface spike protein

Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW*, Hsu STD*
The recent outbreaks of severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and the severe pig pandemics caused by the emerging porcine coronavirus, remind us how infection by coronaviruses can impact our health and socioeconomics.

Lin ch 20191016

The enzymatic tools that catalyze a stepwise demethylation process on terpene scaffold

Chi-Fang Lee, Li-Xun Chen, Chen-Yu Chiang, Chen-Yu Lai, Hsiao-Ching Lin*
A research team led by Dr. Hsiao-Ching Lin, an assistant research fellow at the Institute of Biological Chemistry, has elucidated and characterized the biosynthetic pathway of the aculenes, a unique class of fungal norsequiterpenes.

ChenRH 2019 ASB11s Photo

Cell biology studies identify the key control of cell life-death decision for the development of a new anti-cancer strategy

Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH
A research team led by Dr. Ruey-Hwa Chen, Distinguished Research Fellow at the Institute of Biological Chemistry, has discovered a ubiquitin-dependent mechanism in controlling the life-death cell fate in response to different cellular stresses.

Yao 2019 Pub small

Uncovering the mystery of how oxidative stress, the culprit of aging and neurodegenerative diseases, accumulates and operates in the motor system

Peng JJ, Lin SH, Liu YT, Lin HC, Li TN, Yao CK
Increased oxidative stress is considered to be one of the key factors leading to aging and neurodegenerative diseases, but it is not clear why oxidative stress can accumulate in the nervous system and affect the functioning of the nervous system.

tsai 20192s

IBC Researchers Discovered That Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-mediated Functions

Chang YK, Huang YP, Liu XX, Ko TP, Bessho Y, Kawano Y, Maestre-Reyna M, Wu WJ*, Tsai MD*
A team led by Academician Ming-Daw Tsai, a Distinguished Research Fellow, and Dr. Wen-Jin (Winston) Wu, an Associate Research Specialist at the Institute of Biological Chemistry has discovered that human DNA polymerase μ can use a noncanonical mechanism for multiple Mn2+-mediated functions. The research article has appeared on the May 29th issue of Journal of the American Chemical Society.