Visualizing the DNA repair process by a photolyase at atomic resolution
[Science (2023)]
 
 
   
  Tumor suppressor p16
[Mol. Cell 1, 421 (1998)]
DNA polymerase X from ASFV
[Nature Struc. Biol. (2001)]

Enzymology of
Phospholipase A2
[Chemical Reviews (2001)]
 

Ki67FHA-NIFK 3P
[Nature Struc. Mol. Biol.  (2005)]
 
   
 

Mechanism of DNA polymerases
[Chemical Reviews  (2006)]

The ARID domain of RBP2
[Nature Struc. Mol. Biol. (2008)]

Dun1 FHA -
diphosphorylated SCD
[Molecular Cell (2008)]

FHA domain review
[Science Signaling (2008)]

 
   
 

NP as a new anti-influenza target
[PNAS (2011)]

Non-Watson-Crick pairing by Pol X
[JACS (2014)]

TIFA and inflammasome
[PNAS (2016)]

TIFA and leukemia
[Cancer Research (2017)]

 
   
 

How DNA polymerases catalyze
replication and repair with
contrasting fidelity (2017)

Cryo-EM in enzymology
[JACS (2019)]

Mn2+ specificity of Pol μ
[JACS (2019)]

Temp-resolved Cryo-EM
[JACS (2019)]

 
   
 

Cryo-EM of DMC1
[Nat Commun (2021)]

Cryo-EM review
[Annu. Rev. Biophys. (2022)]

Photolyase by XFEL
[Nature Chemistry (2022)]

A novel ATP site
[Nature Metabolism (2023)]

 
 

Current Research Projects:
Taiwan Protein Project (TPP)
FHA Signaling and Phosphoproteomics
Tumor Suppressors and Cancer Proteins
Histone Demethylases and RBP2
Kinetic Mechanism and Structures of DNA Polymerases
Drug Discovery against Influenza Virus
Past Research Projects (Mechanistic Enzymology):
Capsular Polysaccharide Biosynthesis of K. pneumoniae (2005-2012)
Phosphatidyl Inositide-specific Phospholipase C (1992-2005)
Phospholipase A2 (PLA2) (1988-2004)
Adenylate Kinase (1985-96)
Phospholipids Chiral at Phosphorus (1982-92)
Quadrupolar NMR in Biology (1982-89)
Chiral Phosphates (1979-84)

 

C. V. and Publication List
中 文 簡 歷

The Microscopic World of Proteins (2023)