Institute of Biological Chemistry, Academia Sinica

Research

Manager of ASCEM, Department of Academic Affairs and Instrument Service, Academia Sinica

1. CryoEM
2. AFM
3. UHV-TEM
4. Carbon Nanotube Probe

Degrees and Positions Held

• 1999 – 2004   Ph.D., Graduate School of Engineering Science & Technology, National Yunlin University of Science & Technology
• 1997 – 1999   M.S., Inst. of Mechanical Engineering, National Yunlin University of Science & Technology

• 2021 – present   Associate Research Specialist, Institute of Biological Chemistry / DAAIS, Academia Sinica
• 2017 – 2020   Associate Research Specialist, Institute of Cellular and Organismic Biology / DAAIS, Academia Sinica
• 2011 – 2017 Assistant Research Specialist, Institute of Cellular and Organismic Biology / DAAIS, Academia Sinica
• 2004 – 2010 Postdoctoral Fellow, Nanoscience Lab@Institute of Physics, Academia Sinica
• 1999 – 2003 Research assistant, Nanoscience Lab@Institute of Physics, Academia Sinica

Selected Publications

Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function. 
Yang TJ, Yu PY, Chang YC, Liang KH, Tso HC, Ho MR, Chen WY, Lin HT, Wu HC, Hsu STD* 
Nature Structural & Molecular Biology (2021)

Cryo-EM Analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans. 
Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu SD. 
Proceedings of the National Academy of Sciences of the United States of America (2020)

Temperature-resolved Cryo-EM Uncovers Structural Bases of Temperature-dependent Enzyme Functions. 
Chen CY, Chang YC, Lin BL, Huang CH, Tsai MD. 
Journal of the American Chemical Society (2019)

Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase. 
Chen CY, Chang YC, Lin BL, Lin KF, Huang CH, Hsieh DL, Ko TP, Tsai MD. 
Journal of the American Chemical Society (2019)

Hollow Cone Electron Imaging for Single Particle 3D Reconstruction of Proteins. 
Tsai CY, Chang YC, Lobato I, Van Dyck D, Chen FR. 
Scientific Reports (2016)

Critical Capillary Absorption of Current-Melted Silver Nanodroplets into Multiwalled Carbon Nanotubes. 
Chen YS, Chang YC, Wang SC, Chen LY, Lien DH, Chen LJ, Chang CS. 
Small (2012)

In situ tailoring and manipulation of carbon nanotubes. 
Chang YC, Liaw YH, Huang YS, Hsu T, Chang CS, Tsong TT. 
Small (2008)

Nanoscale doping fluctuation resolved by electrostatic force microscopy via the effect of surface band bending. 
Chin SC, Chang YC, Chang CS, Woon WY, Lin LT, Tao HJ. 
Applied Physics Letters (2008)

Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homologous juxtaposition and strand-assimilation. 
Chen YK, Leng CH, Olivares H, Lee MH, Chang YC, Kung WM, Ti SC, Lo YH, Wang AH, Chang CS, Bishop DK, Hsueh YP, Wang TF. 
Proceedings of the National Academy of Sciences of the United States of America (2004)

Easy method to adjust the angle of the carbon nanotube probe of an atomic force microscope. 
Chang YC, Wang DC, Chang CS, Tsong TT. 
Applied Physics Letters (2003)

Publication List