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Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Chem Commun (Camb). 2020 Apr 30;56(34):4672-4675. Epub 2020 Mar 25.
doi: 10.1039/c9cc07931a

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Abstract

Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold.