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Year Month   
2019/1  Seminars
Seminar Title Structural views of intracellular proteolytic machines
Time Y/M/D 2019/1/7 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Chung-I Chang
Current Position Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan
Host Dr. Tzu-Ching Meng
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
 
Seminar Title [Cancelled!] Studying Oxygen Sensing Pathways in Cancer
Time Y/M/D 2019/1/8 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Qing Zhang
Current Position Assistant Professor, Department of Pathology& Lab Medicine, Department of Pharmacology, The University of North Carolina at Chapel Hill, USA
Host Dr. Ruey-Hwa Chen
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
Abstract Hypoxia is a characteristic of most solid cancers, which is associated with resistance towards radiation and chemotherapy. As tumors grow, they can sense the oxygen tension and reprogram critical pathways that are important for cancer cell survival and therapy resistance. One of examples is through upregulation of hypoxia inducible factorα (HIFα) and activation of HIF signaling downstream pathways. My lab is mainly interested in studying the oxygen-sensing pathway and how they contribute to the development of tumors as well as therapeutic resistance. One of the central players in this pathway is prolyl hydroxylase (EglN1, 2 and 3), a family of iron- and 2-oxoglutarate-depedent dioxygenases. EglNs can hydroxylate HIFα on critical proline residues, which will trigger von Hippel-Lindau (VHL)-associated E3 ligase complex binding and lead to HIFα degradation. One of research directions in the lab is trying to identify novel EglN prolyl hydroxylase substrates and examine their role in cancer. The other direction is to focus on examining the VHL and its bona-fide substrates in kidney cancer. Overall, my lab currently studies hypoxia, prolyl hydroxylase and VHL signaling in cancer, especially breast and renal cell carcinomas. Keywords: Hypoxia, oxygen sensing, breast cancer, kidney cancer, VHL, EglN.-Dr. Qing Zhang
 
Seminar Title PTM enzymes & their substrates - Beyond active sites
Time Y/M/D 2019/1/8 14:00 ~ 15:00
Venue IBC R114
Speaker Dr. Meng-Chiao Ho
Current Position Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan
Host Dr. Rita P.-Y. Chen
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
 
Seminar Title 3D Tissue Elongation via ECM-Stiffness Cued Junctional Remodeling
Time Y/M/D 2019/1/9 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Dong-Yuan Chen
Current Position Postdoc, Department of Molecular and Cell Biology, University of California, Berkeley, USA
Host Dr. Guang-Chao Chen
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
 

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