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Year Month   
2018/1  Seminars
Seminar Title TRAIL-ing the ECM for Cell Motility in Organ Morphogenesis
Time Y/M/D 2018/1/2 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Dong-Yuan Chen
Current Position Postdoc, Department of Molecular and Cell Biology, University of California, Berkeley, USA
Host Dr. Guang-Chan Chen
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
 
Seminar Title Integrated Platforms for Cell Signaling Study
Time Y/M/D 2018/1/11 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Hsiung-Lin Tu
Current Position Assistant Research Fellow, Institute of Chemistry, Academia Sinica, Taiwan
Host Dr. Yu-Ling Shih
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
Abstract Regulated cell signaling is essential for the maintenance of all cellular life. In the past few decades, a wealth of knowledge about molecular players and their roles in signal transduction pathways has been discovered and characterized extensively. But in most cases relevant parameters were obtained by using rather bulk assays, therefore masked any heterogeneity may exist at the individual molecule or cell level. Indeed, more and more single cell studies have shown that even isogenic cells respond differently to the same input, and showed that in fact such heterogeneity could be beneficial at the population level. Moreover, high-resolution measurements also revealed that both static and dynamic heterogeneity is not uncommon at the single molecule level. Taken together, these observations strongly suggest one should take high-resolution approach to directly measure both the mean and variation embedded within the system in order to get more holistic understanding of the signaling network. In the presentation, I would share our effort to develop and apply both biophysical and bioengineering platforms to study cell signaling reactions. Specifically valve-based microfluidic devices for the high-throughput and dynamical cell screening application and 2D membrane assays for the high-resolution mechanistic interrogation of cell signaling reactions.-Dr. Hsiung-Lin Tu
 
Seminar Title My glycobiology research at IBC: Siglecs and beyond
Time Y/M/D 2018/1/18 11:00 ~ 12:00
Venue IBC R114
Speaker Dr. Takashi Angata
Current Position Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica, Taiwan
Host Dr. Chun-Hung Lin
Contact Ms. Nancy Liu
TEL 02-27855696#1165
E-mail liukchun@gate.sinica.edu.tw
 

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