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Dr. Shu-Yu Lin
Associate Research Specialist
Room 401, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2785-5696 ext. 4012
FAX: +886-2-2788-9759
fish1025@gate.sinica.edu.tw

Experience in qualitative and quantitative proteomics (iTRAQ, SILAC, label-free) workflows by NanoLC-MS/MS analyses, in conjunction with utilizing a variety of database search engine and data handling programs for high-throughput expression profiling and quantification.

Comprehensive proteome-wide analysis of post-translational modifications, such as phosphorylation, and targeted analysis of protein sumoylation, neddylation and cysteine modifications etc.

Targeted analysis or manual examination of MS and MS/MS data to determine a true protein ID hit from false positive, to rescue false negative from the data, to confirm predicted sequence or modifications, and to determine site-specific PTM.

1997,09 - 2002,07 Ph.D., Chemistry, National Taiwan University

2014,12 - Associate Research Specialist, Inst. of Biological Chemistry / Scientific Instrument Center
2009,01 - 2014,11 Assistant Research Specialist, Inst. of Biological Chemistry / Scientific Instrument Center
2003,06 - 2009,01 Postdoctoral Fellow, and R&D Manager (from 2006), NRPGM Core Facilities for Proteomic Research

SP's Publications

    Publication List
Suppressive regulation of KSHV RTA with O-GlcNAcylation.
Ko YC, Tsai WH, Wang PW, Wu IL, Lin SY, Chen YL, Chen JY, Lin SF Journal of biomedical science (2012)
Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation Sites.
Tsai WH, Wang PW, Lin SY, Wu IL, Ko YC, Chen YL, Li M, Lin SF Frontiers in microbiology (2012)
Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.
Chang CC, Naik MT, Huang YS, Jeng JC, Liao PH, Kuo HY, Ho CC, Hsieh YL, Lin CH, Huang NJ, Naik NM, Kung CC, Lin SY, Chen RH, Chang KS, Huang TH, Shih HM Molecular cell (2011)
Phosphorylation of the zebrafish M6Ab at serine 263 contributes to filopodium formation in PC12 cells and neurite outgrowth in zebrafish embryos.
Huang KY, Chen GD, Cheng CH, Liao KY, Hung CC, Chang GD, Hwang PP, Lin SY, Tsai MC, Khoo KH, Lee MT, Huang CJ PloS one (2011)
Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.
Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC EMBO JOURNAL (2011)
EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.
Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, Kao YR, Lin SC, Chang YC, Lin SY, Chen SJ, Chen HC, Yeh SD, Wu CW Cancer research (2010)
Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence.
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH MOLECULAR & CELLULAR PROTEOMICS (2009)
Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy.
Chang YC, Lin SY, Liang SY, Pan KT, Chou CC, Chen CH, Liao CL, Khoo KH, Meng TC Journal of proteome research (2008)
Precise mapping of increased sialylation pattern and the expression of acute phase proteins accompanying murine tumor progression in BALB/c mouse by integrated sera proteomics and glycomics.
Lin SY, Chen YY, Fan YY, Lin CW, Chen ST, Wang AH, Khoo KH Journal of proteome research (2008)
Concerted experimental approach for sequential mapping of peptides and phosphopeptides using C18-functionalized magnetic nanoparticles.
Hsiao HH, Hsieh HY, Chou CC, Lin SY, Wang AH, Khoo KH Journal of proteome research (2007)

Updated 2013.09.12

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