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Dr. Yun Yen
Joint Appointment Research Fellow
TEL: +886-2-27361661 ext. 2008
FAX: +886-2-23787795

Clinical Oncology, cancer drug development, translational medicine

1985,09 - 1988,12 Ph.D., Pathology and Cell Biology, Thomas Jefferson University
1975,09 - 1982,06 MD, School of Medicine, Taipei Medical College

2014 - present Joint Appointment Research Fellow, Institute of Biological Chemistry, Academia Sinica
2011,08 - present President, Taipei Medical University
2011,08 - present The Ph.D. program for Cancer Biology and Drug Discovery ,Professor, Taipei Medical University
2003,04 - 2011,07 City of Hope, National Medical Center, Professor

    Publications List
Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol.
Sun G,Cheng YW,Lai L,Huang TC,Wang J,Wang J, Wu X, Wang Y, Huang Y, Wang J, Zhang K, Hu S, Yang JR, Yen Y. Oncotarget (2016)
Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo.
Yang SH,Lin HY,Chang VH,Chen CC,Liu YR,Liu YR, Wang J, Zhang K, Jiang X, Yen Y. Oncotarget (2015)
Response to Trevisson et al.
Zhang K,Lin JW,Chiu WT,Yen Y. Genet Med. (2015)
The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitro.
Chen MC,Zhou B,Zhang K,Yuan YC,Un F,Un F, Hu S, Chou CM, Chen CH, Wu J, Wang Y, Liu X, Smith DL, Li H, Liu Z, Warden CD, Su L, Malkas LH, Chung YM, Hu MC, Yen Y. Mol Pharmacol. (2015)
The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor.
Tzeng HE,Yang L,Chen K,Wang Y,Liu YR,Liu YR, Pan SL, Hu S, Yen Y. Oncotarget (2015)
Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma.
Wang J,Zhang K,Wang J,Wu X,Liu X,Liu X, Li B, Zhu Y, Yu Y, Cheng Q, Hu Z, Guo C, Hu S, Mu B, Tsai CH, Li J, Smith L, Yang L, Liu Q,Chu P, Chang V, Zhang B, Wu M, Jiang X, Yen Y. Oncotarget (2015)
A germline missense mutation in CoQ6 is associated with susceptibility to familial Schwannomatosis.
Zhang K, Lin JW, Wang J, Wu X, Gao H, Hsieh YC, Hwu P, Liu YR, Su L, Chiou HY, Wang D, Yuan YC, Whang-Peng J, Chiu WT, Yen Y. Genet Med. (2014)
Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells.
Qiu F,Chen YR,Liu X, Chu CY, Shen LJ,Xu J, Gaur S, Forman HJ, Zhang H, Zheng S, Yen Y, Huang J, Kung HJ, Ann DK. Sci Signal. (2014)
Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductas.
Xie M,Yen Y,Owonikoko TK,Ramalingam SS,Khuri FR,Khuri FR, Curran WJ, Doetsch PW, Deng X. Cancer Res. (2014)
Reciprocal Regulation of Autophagy and dNTP pools in Human Cancer Cells.
Chen W,Zhang L,Zhang K,Zhou B,Kuo ML, Hu S, Chen L, Tang M, Chen YR, Yang L, Ann DK, Yen Y. Autophagy (2014)

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