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Dr. Yane-Shih Wang
Assistant Research Fellow
Room 305, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-27855696 ext. 3050
FAX: +886-2-27889759

Research in the Wang laboratory centers around interface of genetics, chemistry, biology, medicine and biotechnology investigations that explore the protein post-translational modifications (PTMs) and their networks. We are studying bacterial and eukaryotic systems in a multidisciplinary approach that includes expanding genetics codes, protein chemistry, enzymology and structural analysis. With knowledge of PTM studies, we are also seeking the applications in discovering new concepts of protein drug design.

My research currently focus on three subjects in coherence mode: (1) Synthesizing protein with PTMs, e.g., protein ubiquitin-like modifications, methylation and phosphorylation; (2) Biocatalysis: developing novel enzyme for in vivo protein modifications through click-type bioothogonal reactions; (3) Expanding genetic code studies: developing evolved protein translation system for incorporating multiple and different non-canonical amino acids into proteins in vivo.

2007 - 2012 Ph. D., Department of Chemistry, Texas A&M University, USA
1999 - 2001 M.S., Department of Chemistry, National Cheng-Kung University
1995 - 1999 B. S., Department of Chemistry, National Cheng-Kung University

2015,09 - present Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
2012,07 - 2015,08 Postdoctoral Associate, Department of Molecular Biophysics and Biochemistry, Medical School, Yale University, USA
2003,04 - 2007,07 Research Assistant, Institute of Chemistry, Academia Sinica

    Publications List
A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair.
Englert M, Vargas-Rodriguez O, Reynolds NM, Wang YS, Söll D, Umehara T Biochim. Biophys. Acta, Gen. Subj. (2017)
Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase.
Suzuki T, Miller C, Guo LT, Ho JML, Bryson DI, Wang YS, Liu DR, Söll D Nat. Chem. Bioli. (2017)
Probing the catalytic charge-relay system in alanine racemase with genetically encoded histidine mimetic.
Sharma V, Wang YS, Liu WR ACS Chem. Biol. (2016)
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids.
Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ Nat. Biotechnol. (2015)
Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog
Englert M, Nakamura A, Wang YS, Eiler D, Söll D, Guo LT Nucl. Acids Res. (2015)
Exploring the substrate range of wild-type aminoacyl-tRNA synthetases.
Fan C, Ho JM, Chirathivat N, Söll D, Wang YS ChemBioChem (2014)
Polyspecific pyrrolysyl-tRNA synthetases from directed evolution.
Guo LT, Wang YS, Nakamura A, Eiler D, Kavran JM, Wong M, Kiessling LL, Steitz TA, O'Donoghue P, Söll D Proc. Nalt. Acad. Sci. USA (2014)
Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant.
Wang YS, Fang X, Chen HY, Wu B, Wang ZU, Hilty C, Liu WR ACS Chem. Biol. (2013)
Upgrading protein synthesis for synthetic biology.
O'Donoghue P, Ling J, Wang YS, Söll D Nat. Chem. Biol. (2013)
A rationally designed pyrrolysyl-tRNA synthetase mutant with a broad substrate spectrum.
Wang YS, Fang X, Wallace AL, Wu B, Liu WR J. Am. Chem. Soc. (2012)

Updated 2018.08.01

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