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Dr. Hsiao-Ching Lin
Assistant Research Fellow
Room 509, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-27855696 ext. 5090
FAX: +886-2-27889759
hsiaoching@gate.sinica.edu.tw
Hsiao-Ching Lin's Website


        Natural products (NPs) have been an important source of molecules in drug discovery and development. Their diversity scaffolds and semisynthetic derivatives provide new chemical entities (NCEs) and exhibit variety of biological activities with pharmacological potentials. Recent advances in molecular biology, bioinformatics and whole-genome sequencing provided great advances in understanding the genetic and enzymatic basis of natural product biosynthesis.

        Our research consists of the following topics. Each of these topics can be standalone but is at the same time interconnected with each other.
(A) Discovery of bioactive natural products based on activity-guided screening.
(B) Targeted gene cluster discovery and biosynthetic study of bioactive NPs.
(C) Discovery of new NPs by genome mining in microorganisms.
(D) Combinatorial biosynthesis in heterologous expression systems.

2006 - 2011 Ph.D., School of Pharmacy, National Taiwan University
2004 - 2006 M.S., School of Pharmacy, National Taiwan University
2000 - 2004 B.S., School of Pharmacy, Taipei Medical University

2015.05 - present Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
2012,04 - 2015,04 Postdoctoral researcher, Department of Chemical and Biomolecular Engineering, University of California, Los Angeles
2011,07 - 2012,02 Postdoctoral researcher, School of Pharmacy, National Taiwan University

    Publications List
Biosynthesis of Complex Indole Alkaloids: Elucidation of the Concise Pathway of Okaramines.
Lai CY, Lo IW, Hewage RT, Chen YC, Chen CT, Lee CF, Lin S, Tang MC, Lin HC Angewandte Chemie-International Edition (2017)
P450-Mediated Coupling of Indole Fragments to Forge Communesin and Unnatural Isomers.
Lin, H. C.; McMahon T. C.; Patel, A.; Corsello, M.; Simon, A.; Xu, W.; Zhao, M.; Houk, K. N.; Garg, N. K.; Tang, Y J. Am. Chem. Soc. (2016)
Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast.
Tang, M. C., Lin, H. C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y. J. Am. Chem. Soc. (2015)
Efficient Biosynthesis of Fungal Polyketides Containing the Dioxabicyclo-octane Ring System.
Mao, X. M., Zhan, Z. J., Grayson, M. N., Tang, M. C., Xu, W., Li, Y. Q., Yin, W. B., Lin, H. C., Chooi, Y. H., Houk, K. N., Tang, Y. J. Am. Chem. Soc. (2015)
Elucidation of the Concise Biosynthetic Pathway of the Communesin Indole Alkaloids.
Lin, H. C.; Chou, G.; Chooi, Y. H.; McMahan, T. C.; Xu, W.; Garg, N. K.; Tang, Y. Angew. Chem. Int. (2015)
Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of Multifunctional Cytochrome P450 in the Fumagillin Pathway.
Lin, H. C.; Yuta, T., Dhingra, S., Xu, W.; Fukutomi, M.; Chooi, Y. H.; Cane, D. E.; Calvo, A. M; Watanabe, K.; Tang, Y. J. Am. Chem. Soc. (2014)
The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene.
Lin, H. C.; Chooi, Y. H.; Dhingra S.; Xu, W.; Calvo, A. M.; Tang Y. J. Am. Chem. Soc. (2013)
Dibenzocycloheptanoids from the Leaves of Cinnamomum subavenium.
Lin, H. C.; Lee, S. S. J. Nat. Prod. (2012)
Flavonoid Glycosides from the Leaves of Machilus philippinensis.
Lin, H. C.; Tsai, S. F.; Lee, S. S. J. Chin. Chem. Soc. (2011)

Updated 2017.03.08

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