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Dr. Takashi Angata
Associate Research Fellow
Room 614, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-27855696 ext. 6140, 6141
FAX: +886-2-27889759
angata@gate.sinica.edu.tw

    Sialic acids are a family of acidic sugars, abundantly expressed by all vertebrates and also by some bacteria. The goals of our laboratory are two-fold: (1) to understand how interactions between sialic acids and endogenous sialic acid-binding proteins regulate physiological processes in mammals, and (2) to utilize the knowledge to improve human health.
    Our current focus is a family of sialic acid-binding proteins called Siglecs, most of which are expressed in the immune system. Our recent research has revealed that polymorphisms of some Siglecs likely have influence on human diseases and clinical conditions. We are at present trying to obtain deeper mechanistic insight into the molecular and physiological functions of Siglecs, and to reveal connections of Siglec polymorphisms and some other diseases, in hope that these studies will eventually enable us to develop diagnostic methods and/or treatments for the diseases in which sialic acids and Siglecs play some roles.

- 1998,03 Ph.D., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
- 1995,03 M.S., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
- 1993,03 B.S., Department of Biophysics and Biochemistry, School of Science, The University of Tokyo

2013,04 - present Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
2011,03 - 2013,03 Team Leader, RIKEN (Japan)
2009,04 - 2011,03 Specially Appointed Associate Professor, Osaka University (Japan)
2003,04 - 2009,03 Research Scientist, National Institute of Advanced Industrial Science and Technology (Japan)
1998,04 - 2003,03 Post-doctoral fellow, University of California at San Diego (USA)

    Publications List
Associations of genetic polymorphisms of Siglecs with human diseases.
Angata T Glycobiology (2014)
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. J Exp Med (2014)
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.
Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N Cell Mol Life Sci (2013)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T Glycobiology (2013)
Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions.
Yasui K, Angata T, Matsuyama N, Furuta RA, Kimura T, Okazaki H, Tani Y, Nakano S, Narimatsu H, Hirayama F Br J Haematol (2011)
Deletion polymorphism of SIGLEC14 and its functional implications.
Yamanaka M, Kato Y, Angata T, Narimatsu H Glycobiology (2009)
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.
Angata T, Tabuchi Y, Nakamura K, Nakamura M Glycobiology (2007)
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
Angata T, Hayakawa T, Yamanaka M, Varki A, Nakamura M FASEB J (2006)
Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.
Angata T, Margulies EH, Green ED, Varki A Proc Natl Acad Sci USA (2004)
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.
Angata T, Varki A Chem Rev (2002)

Updated 2017.03.08

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