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Dr. Takashi Angata
Associate Research Fellow
Room 614, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-27855696 ext. 6140, 6141
FAX: +886-2-27889759
Takashi Angata's Website

    Sialic acids are a family of acidic sugars, abundantly expressed by all vertebrates and also by some bacteria. The goals of our laboratory are two-fold: (1) to understand how interactions between sialic acids and endogenous sialic acid-binding proteins regulate physiological processes in mammals, and (2) to utilize the knowledge to improve human health.
    Our current focus is a family of sialic acid-binding proteins called Siglecs, most of which are expressed in the immune system. Our recent research has revealed that polymorphisms of some Siglecs likely have influence on human diseases and clinical conditions. We are at present trying to obtain deeper mechanistic insight into the molecular and physiological functions of Siglecs, and to reveal connections of Siglec polymorphisms and some other diseases, in hope that these studies will eventually enable us to develop diagnostic methods and/or treatments for the diseases in which sialic acids and Siglecs play some roles.

- 1998,03 Ph.D., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
- 1995,03 M.S., Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
- 1993,03 B.S., Department of Biophysics and Biochemistry, School of Science, The University of Tokyo

2013,04 - present Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
2011,03 - 2013,03 Team Leader, RIKEN (Japan)
2009,04 - 2011,03 Specially Appointed Associate Professor, Osaka University (Japan)
2003,04 - 2009,03 Research Scientist, National Institute of Advanced Industrial Science and Technology (Japan)
1998,04 - 2003,03 Post-doctoral fellow, University of California at San Diego (USA)

    Publications List
Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates.
Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T BMC evolutionary biology (2017)
Identification of Siglec Ligands Using a Proximity Labeling Method.
Chang L, Chen YJ, Fan CY, Tang CJ, Chen YH, Low PY, Ventura A, Lin CC, Chen YJ, Angata T J Proteome Res (2017)
Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.
Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, Paré PD, Lomas DA, Silverman EK, Taniguchi N, Kida K Respirology (2017)
O-GlcNAcylation is required for B cell homeostasis and antibody responses.
Wu JL, Chiang MF, Hsu PH, Tsai DY, Hung KH, Wang YH, Angata T, Lin KI Nature communications (2017)
Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.
Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A EMBO J. (2015)
Therapeutic targeting of Siglecs using antibody- and glycan-based approaches.
Angata T, Nycholat CM, Macauley MS Trends Pharmacol Sci (2015)
Associations of genetic polymorphisms of Siglecs with human diseases.
Angata T Glycobiology (2014)
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.
Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. J Exp Med (2014)
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation.
Angata T, Ishii T, Motegi T, Oka R, Taylor RE, Soto PC, Chang YC, Secundino I, Gao CX, Ohtsubo K, Kitazume S, Nizet V, Varki A, Gemma A, Kida K, Taniguchi N Cell Mol Life Sci (2013)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
Takamiya R, Ohtsubo K, Takamatsu S, Taniguchi N, Angata T Glycobiology (2013)

Updated 2018.08.01

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