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Dr. Chung-I(pronounced"yi")  Chang
Associate Research Fellow
Room 707, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2785-5696 ext. 7110, 7070
FAX: +886-2-2788-9759
chungi@gate.sinica.edu.tw

Intracellular protein degradation serves multiple vital functions in all living cells. For example, selective degradation of regulatory proteins such as transcription factors and cell cycle regulators allows rapid change in their concentration within the cell, which represents an effective form of regulation. Another important function of intracellular proteolysis is to rid the cell of potentially harmful proteins that are misfolded or damaged, which may be altered due to abnormal post-translational modification or may fail to assemble properly into complexes. These aberrant proteins may form toxic aggregates within the cell and thus need to be eliminated. Impaired or dysregulated intracellular protein degradation can lead to a wide variety of disease states. Our laboratory is interested in elucidating the structural mechanism of proteins involved in three major protein degradation systems in cells: the AAA+ proteolytic machines, autophagy, and phagocytosis. We take an integrated structural biology approach combining X-ray crystallography, nuclear magnetic resonance spectroscopy (NMR), and electron microscopy (EM) single-particle structure determination methods. We hope that our work will lead to a better understanding of the action mechanisms of proteins involved in intracellular protein degradation, which may aide the design of novel therapeutic strategies for treating diseases.

1997 - 2002 Ph.D., Molecular Biophysics, University of Texas Southwestern Medical Center at Dallas
1990 - 1992 M.S., Graduate Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine
1986 - 1990 B.S., School of Pharmacy, National Taiwan University College of Medicine

2010 - present Adjunct Associate Professor, Institute of Biochemical Sciences, College of Life Science, National Taiwan University
2009 - present Associate Research Fellow (Tenured 2014), Institute of Biological Chemistry, Academia Sinica
2006 - 2009 Research Scientist, Array BioPharma Inc., Protein Biology Group
2002 - 2006 HHMl Associate, Howard Hughes Medical Institute

    Publications List
Structural Basis for the Magnesium-Dependent Activation and Hexamerization of the Lon AAA+ Protease.
Su, S.-C., Lin, C.-C., Tai, H.-C., Ho, M.-R., Chang, M., Babu, S., Liao, J.-H., Wu, S.-H, Chang, Y.-C., Lim, C., and Chang, C.-I Structure (2016)
Structural Insights into the Allosteric Operation of the Lon AAA+ Protease.
Lin, C.-C., Su, S.-C., Su, M.-Y., Liang, P.-H., Fang, C.-C., Wu, S.-H., and Chang, C.-I Structure (2016)
Structure of yeast Ape1 and its role in autophagic vesicle formation.
Su MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI Autophagy (2015)
Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors. (Cover article)
J.-H. Liao, K. Ihara, C.-I. Kuo, K.-F. Huang, S. Wakatsuki, S.-H. Wu and C.-I. Chang Acta Crystallographica Section D Biological Crystallography (2013)
Three-Dimensional Structure of Human NLRP10/PYNOD Pyrin Domain Reveals a Homotypic Interaction Site Distinct from Its Mouse Homologue.
Ming-Yuan Su, Chiao-I Kuo, Chi-Fon Chang, Chung-I Chang PLOS ONE (2013)
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase.
Wei-Jan Huang, Ching-Chow Chen, Shi-Wei Chao, Chia-Chun Yu, Chen-Yui Yang, Jih-Hwa Guh, Yun-Chieh Lin, Chiao-I Kuo, Ping Yang and Chung-I Chang EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structural basis for conserved complement factor-like function in the antimalarial protein TEP1.
Baxter RH, Chang CI, Chelliah Y, Blandin S, Levashina EA, Deisenhofer J. Proceedings of the National Academy of Sciences of the United States of America (2007)
Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
Chang CI, Chelliah Y, Borek D, Mengin-Lecreulx D, Deisenhofer J. Science (2006)
Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition.
Chang CI, Ihara K, Chelliah Y, Mengin-Lecreulx D, Wakatsuki S, Deisenhofer J. Proceedings of the National Academy of Sciences of the United States of America (2005)
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity.
Chang CI, Pili-Floury S, Herve M, Parquet C, Chelliah Y, Lemaitre B, Mengin-Lecreulx D, Deisenhofer J. PLoS Biol. (2004)

Updated 2017.03.08

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