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Dr. Guang-Chao Chen
Associate Research Fellow
Room 701, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2785-5696 ext. 7010/ 7011
FAX: +886-2-2788-9759

Guang-Chao Chen Lab

Functional analysis of PTPs in development and human diseases

Protein tyrosine phosphatases (PTPs) are a group of tightly regulated enzymes that coordinate with protein tyrosine kinases (PTKs) to control protein phosphorylation during cell adhesion and migration. To explore the functional role of PTPs in cell adhesion and migration, we performed genetic analyses to identify PTPs that could modulate border cell migration during Drosophila oogenesis. Depletion of Myopic (Mop), the Drosophila homolog of human HDPTP/PTPN23, resulted in aberrant integrin distribution and border cell dissociation. We further identified Rab4 GTPase as an interactor of Mop/HDPTP. HDPTP regulates Rab4 distribution, integrin trafficking, and cell motility. We also found that the FERM and PDZ domain-containing protein tyrosine phosphatase, dPtpmeg/PTPN3, negatively regulates EGFR/Ras/MAPK signaling pathway. Our recent data indicate that PTPN3 promotes EGFR degradation and inhibits lung cancer cell proliferation and migration.

Molecular signaling and PTM of autophagy

Autophagy is a process by which components of the cytoplasm (the jelly-like substance that fills a cell) are engulfed and degraded; it has recently been found to play an important role in development and in certain human diseases such as cancer, immune response, and neurodegeneration. We are applying genetic, cell biologic, and biochemical approaches to study the molecular machinery of autophagy.

- 1997 Ph.D., Molecular Genetics, University of Texas at Austin

2013 - present Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
2013 - present Joint Associate Professor, Institute of Biochemical Sciences, National Taiwan University
2007 - 2013 Adjunct Assistant Professor, Institute of Biochemical Sciences, National Taiwan University
2006 - 2012 Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica
1998 - 2005 Postdoctoral Fellow, MGH Cancer Center and Harvard Medical School

    Publications List
Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.
Wen JK, Wang YT, Chan CC, Hsieh CW, Liao HM, Hung CC, and Chen GC eLife (2017)
The role of ubiquitin system in autophagy.
Wang YT and Chen GC Autophagy in Current Trends in Cellular Physiology and Pathology (2016)
Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation.
Li MY, Lai PL, Chou YT, Chi AP, Mi YZ, Khoo KH, Chang GD, Wu CW, Meng TC, Chen GC Oncogene (2015)
Structure of yeast Ape1 and its role in autophagic vesicle formation.
u MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI Autophagy (2015)
Ecdysone-induced receptor tyrosine phosphatase PTP52F regulates Drosophila midgut histolysis by enhancement of autophagy and apoptosis.
Santhanam A, Peng WH, Yu YT, Sang TK, Chen GC, Meng TC Mol Cell Biol. (2014)
Atg9 Interacts with dTRAF2/TRAF6 to Regulate Oxidative Stress-Induced JNK Activation and Autophagy Induction.
Hong-Wen Tang, Hsiao-Man Liao, Wen-Hsin Peng, Hong-Ru Lin, Chun-Hong Chen, Guang-Chao Chen Developmental Cell (2013)
Evaluation of Drosophila metabolic labeling strategies for in vivo quantitative proteomic analyses with applications to early pupa formation and amino acid starvation.
Chang YC, Tang HW, Liang SY, Pu TH, Meng TC, Khoo KH, Chen GC JOURNAL OF PROTEOME RESEARCH (2013)
The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration.
Chen DY, Li MY, Wu SY, Lin YL, Tsai SP, Lai PL, Lin YT, Kuo JC, Meng TC, Chen GC J Cell Sci. (2012)
Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.
Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC EMBO JOURNAL (2011)
Unraveling the role of myosin in forming autophagosomes.
Tang HW, Chen GC Autophagy (2011)

Updated 2018.08.01

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