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Dr. Shih-Hsiung Wu
Distinguished Research Fellow
Room 712, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-27855-696 ext. 7101
FAX: +886-2-2788-9759
shwu@gate.sinica.edu.tw

The study on relationship of structure and function of biomolecules is the main theme of our research. The basic techniques used in our studies include NMR, GC-Mass and MS, BIAcore, CD, organic synthesis, cloning, site-directed mutagenesis and other physical methods and chromatographies. At present, our works focus on several topics described as follows:

• Carbohydrate Chemistry and Glycobiology

•Drug Discovery and Development from the Secondary metabolites of microorganisms

•Studies on the structure-functional relationship of proteins and peptides by NMR and X-ray diffraction

•Proteomic studie

- 1987 Ph.D. , Pharmacy , University of Wisconsin, Madison.
- 1977 M.S. , Biochemistry , National Taiwan University
- 1975 B.S. , Botany , National Taiwan University

2008,07 - present Distinguished Research Fellow, Institute of Biological Chemistry, Academia Sinica
1991,08 - present Professor, Institute of Biochemical Science, National Taiwan University College of Life Science
2006,12 - 2012,07 Deputy Director, Institute of Biological Chemistry, Academia Sinica
1998,06 - 1999,05 General Secretary , Taiwan Society of Biochemistry and Molecular Biology
1997,10 - 1999,10 Deputy Director , Institute of Biological Chemistry, Academia Sinica
1994,08 - 1995,07 Visiting Scholar , The Scripps Research Institute
1991,07 - 2008,07 Research Fellow , Institute of Biological Chemistry
1988,04 - 1991,06 Associate Research Fellow , Institute of Biological Chemistry
1979,03 - 1988,03 Assistant Research Fellow , Institute of Biological Chemistry
1978,02 - 1979,02 Group Leader , Panlabs Taiwan Ltd

    Publications List
Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27.
Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, Wu SH Molecular & Cellular Proteomics (2013)
A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2.
Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, Wu SH Journal of biological chemistry (2011)
Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis.
Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, Wu SH Inorganic chemistry (2011)
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4.
Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, Wu SH Journal of biological chemistry (2011)
The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.
Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis.
Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, Wu SH Journal of medicinal chemistry (2010)
iscovery of New Natural Products by Intact-cell Mass Spectrometry and LC-SPE-NMR--Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea.
Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and S-H. Wu CHEMISTRY-A EUROPEAN JOURNAL (2009)
Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence.
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH. Mol Cell Proteomics (2009)
Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA.
Chen SH, Suzuki CK, Wu SH Nucleic acids research (2008)
Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora Thermophila: Elucidation of the Relationship between Cytotoxicity and Stereoconfiguration.
Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and S. H. Wu CHEMISTRY-A EUROPEAN JOURNAL (2007)

Updated 2017.03.08

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