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Dr. Po-Huang Liang
Research Fellow & Acting Associate Director
Room 309, Institute of Biochemical Sciences, National Taiwan University
No. 1, Sec. 4, Roosevelt Rd., Taipei 106, Taiwan
TEL: +886-2-2366-5539
FAX: +886-2-2363-5038

Our laboratory has been focusing on (i) mechanistic and structural studies of prenyltransferases catalyzing chain elongation, such as undecaprenyl diphosphate synthase, octaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase; (ii) antivirus and anti-cancer drug discovery targeting 3C protease from Enterovirus 71, 3C-like proteases from SARS-CoV and MERS-CoV, neuraminidase from avian flu virus, and protein-protein interactions; (iii) multi-functional cellulose/hemicellulose degrading enzymes for biofuel production.

1989 - 1994 Ph.D., Biochemistry, University of Maryland.
1982 - 1986 B. S., Chemistry, National Taiwan University.

2017,08 - present Acting Associate Director, Institute of Biological Chemistry, Academia Sinica
2009 - present Council Member, The Taiwan society for Biochemistry and Molecular Biology
2007 - present Joint Professor, Insti. of Biochemical Sciences, National Taiwan University
2007 - present Editorial Board, Bioorganic Chemistry (Elsevier) and JCCS
2006,11 - present Research fellow, Institute of Biological Chemistry, Academia Sinica
2017,07 - 2017,08 Associate Director, Institute of Biological Chemistry, Academia Sinica
2010 - 2015 Council Member, Asia Pacific Protein Association (APPA)
2007 - 2016 Council Member, Biophysics society of ROC
2006,12 - 2011,08 Associate Director, Institute of Biological Chemistry, Academia Sinica
2005,05 - 2008,04 PI, Core Facility of Recombinant Protein Production
2004,07 - 2011,12 Chem Biology & Mol Biophys Coordinator, TIGP
2002,11 - 2006,10 Associate Research Fellow, Institute of Biological Chemistry, Academia Sinica
1999,03 - 2002,10 Assistant Research Fellow, Institute of Biological Chemistry, Academia Sinica.
1996,10 - 1999,02 Investigator, SmithKline Beecham Pharmaceuticals.
1995,07 - 1996,09 Associate Research Scientist, Yale Medical School.
1994,05 - 1995,06 Postdoc. Pharmacology, Yale Medical School.

    Publications List
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLpro inhibitors.
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH Antiviral research (2017)
Fluorescent farnesyl diphosphate analogue: A probe to validate trans-prenyltransferase inhibitors.
Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH BIOCHEMISTRY (2016)
Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.
Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH The Journal of biological chemistry (2015)
Identification, synthesis and evaluation of new neuraminidase inhibitors.
Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng, YS, Liang PH Organic Letters (2014)
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction.
Chang CK, Teng KH, Lin SW, Chang TH, Liang PH Biochemistry (2013)
Targeting the XIAP/caspase-7 complex selectively kills caspase-3 deficient malignancies.
Lin, Y. F. Lai, T. C., Chang, C. K., Chen, C.L., Huang, M.S., Yang, C.J., Liu, H. G., Dong, J. J., Chou, Y.A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M., and Liang, P. H. J. Clinical Investigation (2013)
Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.
Lin YF, Lee YF, Liang PH Cell Death & Disease (2012)
Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability.
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Chia-Hsiang Lo, Ying-Hsuan Chang, Jon D. Wright, Shih-Hsun Chen, Daphne Kan, Carmay Lim, and Po-Huang Liang Journal of the American Chemical Society (2009)
Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.
Yuan-Feng Lin, Wen-Ping Tsai, Hon-Ge Liu, and Po-Huang Liang Cancer Research (2009)

Updated 2018.08.01

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