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Dr. Chang-Jen Huang
Research Fellow
Room 507, Institute of Biological Chemistry, Academia Sinica
128, Academia Road Sec. 2, Nankang, Taipei 115, Taiwan
TEL: +886-2-2785-5696 ext. 5070
FAX: +886-2-2788-9759
Chang-Jen Huang's Website

Dr. Huangs research interest is to use zebrafish as a model organism to study JAK/STAT signal transduction pathway in fish as well as to establish disease model for drug screen. Loss-of-function was performed by using morpholino oligonucleotides to knockdown gene expression during development, while gain-of-function was performed by overexpression of selected gene under the control of tissue-specific promoter in zebrafish embryos. In addition, different transgenic zebrafish line with GFP expression in specific organ or tissue was generated for the study of functional genomics. At present, we are working in several topics including:

1.JAK/STAT signal transduction pathway in fish;

2.Enhancement and inhibition of neurite outgrowth during zebrafish development;

3.Establishment of neurodegenerative disease model in zebrafish, such as spinal cord injury and Parkinson disease;

4.Expression and characterization of p53 family proteins during zebrafish development.

1989 - 1992 Ph.D., Graduate Institute of Biochemical Sciences, National Taiwan University
1976 - 1978 MS, Graduate Institute of Biochemical Sciences, National Taiwan University
1972 - 1976 BS, Dept. of Zoology, National Taiwan Univ.

2004,04 - present Fellow, Institute of Biological Chemistry, Academia Sinica
1994 - 2004,04 Associate Research Fellow, IBC
1988 - 1994 Assistant Researcher, IBC
1983 - 1984 Visiting Researcher, Dept. of Molecular Biology, Scripps Research Institute, San Diego, USA
1981 - 1988 Assistant Research Fellow, Institute of Preventive Medicine, National Defense Medical Center

    Publications List
Differential regulation of Tetraodon nigroviridis Mx gene promoter activity by constitutively-active forms of STAT1, STAT2, and IRF9.
Cheng, C. H., Chou, C. M., Chu, C. Y., Chen, G. D., Lien, H. W., Hwang, P. P., Chang, M. S., and Huang, C. J. Fish and Shellfish Immunology (2014)
The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor.
Han, H. W., Chou, C. M., Chu, C. Y., Cheng, C. H., Yang, C. H., Hung, C. C., Hwang, P. P., Lee, S. J., Liao, Y. F., and Huang, C. J. PLoS One (2014)
A novel zinc finger protein 219-like (ZNF219L) is involved in the regulation of collagen type 2 alpha 1a (col2a1a) gene expression in zebrafish notochord.
Lien, H. W., Yang C. H., Cheng, C. H., Hung, C. C., Liao, W. H., Hwang, P. P., Han, Y. S., and Huang, C. J. Int. J. Biol. Sci. (2013)
Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling.
Liao WH, Cheng CH, Hung KS, Chiu WT, Chen GD, Hwang PP, Hwang SP, Kuan YS, Huang CJ Cellular and molecular life sciences : CMLS (2013)
Phosphorylation of the Zebrafish M6Ab at Serine 263 Contributes to Filopodium Formation in PC12 Cells and Neurite Outgrowth in Zebrafish Embryos.
Huang KY, Chen GD, Cheng CH, Liao KY, Hung CC, Chang GD, Hwang PP, Lin SY, Tsai MC, Khoo KH, Lee MT, Huang CJ PloS one (2011)
Zona Pellucida Domain-Containing Protein beta-Tectorin is Crucial for Zebrafish Proper Inner Ear Development.
Yang CH, Cheng CH, Chen GD, Liao WH, Chen YC, Huang KY, Hwang PP, Hwang SP, Huang CJ PloS one (2011)
Identification and characterization of alternative promoters of the zebrafish Rtn-4/Nogo genes in cultured cells and in zebrafish embryos.
Chen Y.C., Wu B.K., Chu C.Y., Cheng C.H., Han H.W., Chen G.D., Lee M.T., Hwang P.P., Kawakami K., Chang C.C., Huang C.J. Nucleic Acids Research (2010)
Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using GFP reporter gene.
Y. C. Chen, C. H.Cheng, G. D.Chen, C. C. Hung, C. H.Yang, S. P.Hwang, K. Kawakami, B. K. Wu and C. J. Huang Developmental Dynamics (2009)
Erythropoietins from teleosts.
C. Y. Chu, C. H. Cheng, C. H. Yang and C. J. Huang Cellular and Molecular Life Sciences (2008)
The zebrafish erythropoietin: functional identification and biochemical characterization
C. Y. Chu, C. H. Cheng, G. D. Chen, Y. C. Chen, C. C. Hung, K. Y. Huang and C. J. Huang FEBS Letters (2007)

Updated 2018.08.01

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