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蔡明道 博士
特聘研究員
中央研究院生物化學研究所 316室
臺北市南港區115研究院路二段128號
TEL: +886-2-2785-5696 ext. 3070
FAX: +886-2-2788-9759
mdtsai@gate.sinica.edu.tw
蔡明道的個人網站


本實驗室研究重點是細胞週期進程中的蛋白質交互作用及訊息傳遞,尤其是癌細胞和病毒感染方面。我們在INK4、Ki67、CHK2蛋白質的結構和功能研究中,為一些癌症的機制研究提供了新契機。此外,我們研究人類(例如MDC1)和酵母(Rad53及Dun1)FHA domain傳達的蛋白質和磷蛋白之間的反應訊息路徑及結構。本實驗室另一個計畫著重在DNA聚合酶催化反應機制和生化功能,包括人類DNA聚合酶beta及lambda和非洲豬瘟病毒(African swine fever virus, ASFV)所帶有的DNA聚合酶X。研究此酵素特性使我們更進一步了解DNA層次的損傷反應和修復。

- 1978 Ph.D, Biochemistry & Medicinal Chemistry, Purdue University
- 1972 B.S., Chemistry, National Taiwan University, Taipei

2010 - present 副編輯, Biochemistry
2008,08 - present 特聘研究員, 中研院生化所
2012 - 2012 院士, 中央研究院
2008,08 - 2014,08 所長, 中研院生化所
2006,10 - 2008,08 代所長, 中研院生化所
2005 - 2008 Director, Division of Functional Genomics, Genomics Research Center
2003 - 2008 Director, National Research Program for Genomic Medicine Core Facility Office
1995 - 2003 Director, Chemistry/Biology Interface Training Program, OSU
1993 - 2007 Director, Office of Research Campus Chemical Instrument Center, The Ohio State University
1992 - 1992 Elected Fellow, American Association for the Advancement of Science (AAAS)
1992 - 1992 Distinguished Scholar Award, Ohio State University
1985 - 1990 Camille and Henry Dreyfus Teacher-Scholar
1985 - 1985 Faculty Research Award, Ohio State Chapter of Sigma Xi
1983 - 1985 Alfred P. Sloan Fellow
1981 - 2006 Kimberly Professor of Chemistry and Professor of Biochemistry, The Ohio State University (starting as Assistant Professor)

    論文列表
How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation.
Wen-Jin Wu, Mei-I Su, Jian-Li Wu, Sandeep Kumar, Liang-hin Lim, Chun-Wei Eric Wang, Frank H. T. Nelissen, Ming-Chuan Chad Chen, Jurgen F. Doreleijers, Sybren S. Wijmenga, and Ming-Daw Tsai J. Am. Chem. Soc. (2014)
Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.
Eric S.-W. Chen, Nicolas C. Hoch, Shun-Chang Wang, Achille Pellicioli, Jörg Heierhorst, and Ming-Daw Tsai Mol Cell Proteomics (2014)
E339…R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors.
Yu-Fang Shen, Yu-Hou Chen, Shao-Ying Chu, Meng-I Lin, Hua-Ting Hsu, Pei-Yu Wu, Chao-Jung Wu, Hui-Wen Liu, Fu-Yang Lin, Gialih Lin, Pang-Hung Hsu, An-Suei Yang, Yih-Shyun E. Cheng, Ying-Ta Wu, Chi-Huey Wong, Ming-Daw Tsai Proceedings of the National Academy of Sciences of the United States of America (2011)
Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.
H. Lee, C. Yuan, A. Hammet, A. Mahajan, S. W. Chen, M. R. Wu, M. I. Su, J. Heierhorst, M. D. Tsai Mol. Cell (2008)
Structure and Function of the Phosphothreonine-Specific FHA Domain.
Anjali Mahajan, Chunhua Yuan, Hyun Lee, Eric S.-W. Chen, Pei-Yu Wu, Ming-Daw Tsai Science Signaling (2008)
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.
Shengjiang Tu, Yu-Ching Teng, Chunhua Yuan, Ying-Ta Wu, Meng-Yu Chan, An-Ning Cheng, Po-Hsun Lin, Li-Jung Juan, Ming-Daw Tsai NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Mechanistic comparison of high-fidelity and error-prone DNA polymerases and ligases involved in DNA repair.
Showalter AK, Lamarche BJ, Bakhtina M, Su MI, Tang KH, Tsai MD Chemical reviews (2006)
Sequential Phosphorylation and Multisite Interactions Characterize Specific Target Recognition by the FHA Domain of Ki-67.
In-Ja L. Byeon, Hongyuan Li, Haiyan Song, Angela M. Gronenborn, and Ming-Daw Tsai Nature Structural and Molecular Biology (2005)
Solution structure of a viral DNA polymerase X and evidence for a mutagenic function.
A. K. Showalter, I. J. Byeon, M. I. Su and M. D. Tsai Nat Struct Biol (2001)
Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.
I. J. Byeon, J. Li, K. Ericson, T. L. Selby, A. Tevelev, H. J. Kim, P. O'Maille and M. D. Tsai Mol Cell (1998)

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