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吳世雄 博士
特聘研究員
中央研究院生物化學研究所 712室
臺北市南港區115研究院路二段128號
TEL: +886-2-27855-696 ext. 7101
FAX: +886-2-2788-9759
shwu@gate.sinica.edu.tw

The study on relationship of structure and function of biomolecules is the main theme of our research. The basic techniques used in our studies include NMR, GC-Mass and MS, BIAcore, CD, organic synthesis, cloning, site-directed mutagenesis and other physical methods and chromatographies. At present, our works focus on several topics described as follows:

• Carbohydrate Chemistry and Glycobiology

•Drug Discovery and Development from the Secondary metabolites of microorganisms

•Studies on the structure-functional relationship of proteins and peptides by NMR and X-ray diffraction

•Proteomic studie

- 1987 博士, 藥學院, 美國威斯康辛州威斯康辛大學麥迪遜校區
- 1977 碩士, 生化科學研究, 臺灣大學理學院碩士
- 1975 學士, 植物系, 臺灣大學

2008,07 - present 特聘研究員, 中央研究院生化研究所
1991,08 - present 教授, 臺灣大學理學院生化科學研究所
2006,12 - 2012,07 副所長, 中央研究院生化研究所
1998,06 - 1999,05 祕書長, 臺灣生化及分子生物學會
1997,10 - 1999,10 副所長, 中央研究院生化研究所
1994,08 - 1995,07 訪問學者, 美國加州聖地牙哥
1991,07 - 2008,07 研究員, 中央研究院生化研究所
1988,04 - 1991,06 副研究員, 中央研究院生化研究所
1979,03 - 1988,03 助理研究員, 中央研究院生化研究所
1978,02 - 1979,02 藥理研究所組長, 臺灣汎球

    論文列表
Phosphoproteomic analysis reveals the effects of PilF phosphorylation on Type IV pilus and biofilm formation in Thermus thermophilus HB27.
Wu WL, Liao JH, Lin GH, Lin MH, Chang YC, Liang SY, Yang FL, Khoo KH, Wu SH Molecular & Cellular Proteomics (2013)
A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2.
Lin MH, Yang YL, Chen YP, Hua KF, Lu CP, Sheu F, Lin GH, Tsay SS, Liang SM, Wu SH Journal of biological chemistry (2011)
Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis.
Liao JH, Chen CS, Hu CC, Chen WT, Wang SP, Lin IL, Huang YH, Tsai MH, Wu TH, Huang FY, Wu SH Inorganic chemistry (2011)
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4.
Yang FL, Yang YL, Liao PC, Chou JC, Tsai KC, Yang AS, Sheu F, Lin TL, Hsieh PF, Wang JT, Hua KF, Wu SH Journal of biological chemistry (2011)
The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.
Liaw CC, Liao WY, Chen CS, Jao SC, Wu YC, Shen CN, Wu SH ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis.
Fang Z, Liao PC, Yang YL, Yang FL, Chen YL, Lam Y, Hua KF, Wu SH Journal of medicinal chemistry (2010)
iscovery of New Natural Products by Intact-cell Mass Spectrometry and LC-SPE-NMR--Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea.
Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and S-H. Wu CHEMISTRY-A EUROPEAN JOURNAL (2009)
Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence.
Lin MH, Hsu TL, Lin SY, Pan YJ, Jan JT, Wang JT, Khoo KH, Wu SH. Mol Cell Proteomics (2009)
Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA.
Chen SH, Suzuki CK, Wu SH Nucleic acids research (2008)
Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora Thermophila: Elucidation of the Relationship between Cytotoxicity and Stereoconfiguration.
Y. L. Yang, C. P. Lu, M. Y. Chen, K. Y. Chen, Y. C. Wu and S. H. Wu CHEMISTRY-A EUROPEAN JOURNAL (2007)

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