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梁博煌 博士
研究員 & 代理副所長
臺灣大學生化科學研究所 309室
臺北市106羅斯福路四段1號
TEL: +886-2-2366-5539
FAX: +886-2-2363-5038
phliang@gate.sinica.edu.tw

Our laboratory has been focusing on (i) mechanistic and structural studies of prenyltransferases catalyzing chain elongation, such as undecaprenyl diphosphate synthase, octaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase; (ii) antivirus and anti-cancer drug discovery targeting 3C protease from Enterovirus 71, 3C-like proteases from SARS-CoV and MERS-CoV, neuraminidase from avian flu virus, and protein-protein interactions; (iii) multi-functional cellulose/hemicellulose degrading enzymes for biofuel production.

1989 - 1994 博士, 化學暨生化系, 美國馬里蘭大學
1982 - 1986 學士, 化學系, 臺灣大學。

2017,08 - present 代理副所長, 中央研究院生物化學研究所
2009 - present 理事, 臺灣生物化學及分子生物學學會
2007 - present 合聘教授, 臺大生命科學院生化所
2007 - present 編輯委員, Bioorganic Chemistry (Elsevier) and JCCS
2006,11 - present 研究員, 中研院生化所
2017,07 - 2017,08 副所長 , 中央研究院生物化學研究所
2010 - 2015 理事, 亞太蛋白質學會
2007 - 2016 理事, 中華民國生物物理學會
2006,12 - 2011,08 副所長, 中研院生化所
2005,05 - 2008,04 主持人, 重組蛋白生產核心設施
2004,07 - 2011,12 Chem Biology & Mol Biophys 召集人, 中研院國際研究生學程
2002,11 - 2006,10 副研究員, 中研院生化所
1999,03 - 2002,10 助研究員, 中研院生化所
1996,10 - 1999,02 研究員, 史克美占藥廠巨分子科學及蛋白質化學系
1995,07 - 1996,09 助理研究員, 美國耶魯大學醫學院藥學系
1994,05 - 1995,06 博士後研究員, 美國耶魯大學醫學院藥學系

    論文列表
Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLpro inhibitors.
Kumar V, Shin JS, Shie JJ, Ku KB, Kim C, Go YY, Huang KF, Kim M, Liang PH Antiviral research (2017)
Fluorescent farnesyl diphosphate analogue: A probe to validate trans-prenyltransferase inhibitors.
Teng KH, Hsu ET, Chang YH, Lin SW, Liang PH BIOCHEMISTRY (2016)
Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum.
Yuan SF, Wu TH, Lee HL, Hsieh HY, Lin WL, Yang B, Chang CK, Li Q, Gao J, Huang CH, Ho MC, Guo RT, Liang PH The Journal of biological chemistry (2015)
Identification, synthesis and evaluation of new neuraminidase inhibitors.
Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng, YS, Liang PH Organic Letters (2014)
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interaction.
Chang CK, Teng KH, Lin SW, Chang TH, Liang PH Biochemistry (2013)
Targeting the XIAP/caspase-7 complex selectively kills caspase-3 deficient malignancies.
Lin, Y. F. Lai, T. C., Chang, C. K., Chen, C.L., Huang, M.S., Yang, C.J., Liu, H. G., Dong, J. J., Chou, Y.A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M., and Liang, P. H. J. Clinical Investigation (2013)
Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivation.
Lin YF, Lee YF, Liang PH Cell Death & Disease (2012)
Construction and characterization of different fusion proteins between cellulases and β-glucosidase to improve glucose production and thermostability.
Lee HL, Chang CK, Teng KH, Liang PH BIORESOURCE TECHNOLOGY (2011)
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthase.
Chia-Hsiang Lo, Ying-Hsuan Chang, Jon D. Wright, Shih-Hsun Chen, Daphne Kan, Carmay Lim, and Po-Huang Liang Journal of the American Chemical Society (2009)
Intracellular beta-tubulin/Chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.
Yuan-Feng Lin, Wen-Ping Tsai, Hon-Ge Liu, and Po-Huang Liang Cancer Research (2009)

Updated 2015.10.19

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